Sarcopenia : Molecular, Cellular, and Nutritional Aspects – Applications to Humans book cover
1st Edition

Molecular, Cellular, and Nutritional Aspects – Applications to Humans

ISBN 9781032084282
Published June 30, 2021 by CRC Press
454 Pages 8 Color & 42 B/W Illustrations

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Book Description

Sarcopenia: Molecular, Cellular, and Nutritional Aspects describes the progressive loss of skeletal muscle mass and strength, defined by Rosenberg in 1997 as a hallmark of aging and referred to as “sarcopenia”. As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. The condition worsens in the presence of chronic diseases that accelerate its progression. Sarcopenia is not considered to be “a process of normative aging” but according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM), as a disease. As sarcopenia is an unavoidable process, prevention and management are the only options to promote healthy aging, actions that should perhaps should perhaps be taken during youth.

Included in this book:

·       Features essential information on sarcopenia, its current definition, and molecular and cellular aspects of this disease

·       Discusses the development of physical frailty, a complication of sarcopenia, and predicts its occurrence in the older population

·       Presents alterations in muscle protein turnover and mitochondrial dysfunction in the aging process 

·       Provides data on the negative involvement of sarcopenia in certain chronic diseases that can lead to cachexia, a metabolic wasting syndrome

·       Describes presbyphagia or age-related changes in the swallowing mechanism in older people

·       Details possible strategies to combat muscle wasting in healthy older adults and their limitations

This book features information collected from pioneers or experts on human aging from around the globe, including Europe, Brazil, Canada, Japan and the United States. It is a valuable source of information for nutritional scientists, medical doctors, sports scientists, food scientists, dietitians, students in these fields, and for anyone interested in nutrition. We hope this book provides a better understanding of sarcopenia which inevitably occurs with aging without weight loss. The book also provides information outlining strategies to prevent or limit muscle wasting due to normal aging in order to promote successful aging.


Table of Contents


Naji Abumrad

Section 1: Basics of sarcopenia: definition and challenges of sarcopenia research

Chapter 1 Definitions of Sarcopenia

Heike Bischoff-Ferrari and Bess Dawson-Hughes

Section 2: New data on sarcopenia

Chapter 2 Models of Accelerated Sarcopenia

Andrew S. Layne, Lisa M. Roberts and Thomas W. Buford

Chapter 3 Sarcopenia in physical frailty

Maturin Tabue-Teguo, Emanuele Marzetti, Riccardo Calvani et al.


Section 3: Molecular and cellular aspects of sarcopenia

Chapter 4 The role of imaging techniques in the diagnosis of sarcopenia

Thiago Gonzalez Barbosa-Silva and Carla Prado

Chapter 5 Nutrient Sensing and mTORC1 Regulation in Sarcopenia

Ted G. Graber and Blake B. Rasmussen

Chapter 6 Different adaptation of ubiquitin-proteasome and lysosome-autophagy signaling in sarcopenic muscle

Kunihiro Sakuma and Hidetaka Wakabayashi

Chapter 7 Myokines in aging muscle

Katie Brown, Aaron Persinger and Melissa Puppa

Chapter 8 The contribution of satellite cells to skeletal muscle aging

Christopher Fry

Chapter 9 Muscle stem cell microenvironment in sarcopenia

Neia Naldaiz-Gastesi and Ander Izeta

Chapter 10 Sarcopenia and Oxidative stress: from the bench to therapeutical strategies

Coralie Arc-Chagnaud, Allan F. Pagano and Thomas Brioche

Section 4: Alterations in muscle protein turnover in the aging process

Chapter 11 Muscle protein turnover and sarcopenia in the elderly: the effects of nutrition

Paolo Tessari

Chapter 12 The relationship between muscle mitochondrial turnover and sarcopenia

Heather N. Carter, Nashwa Cheema and David A. Hood

Chapter 13 Skeletal muscle fat infiltration with aging: an important factor of sarcopenia

Allan F. Pagano, Coralie Arc-Chagnaud and Thomas Brioche et al.


Section 5: Recent advances limiting sarcopenia and supporting healthy aging

Chapter 14 Nutritional modulation of mitochondrial-associated death signaling in sarcopenia

Stephen E. Alway

Chapter 15 Beneficial effects and limitations of strategies (nutritional or other) to limit muscle wasting due to normal aging

Dominique Meynial-Denis


Section 6: Applications

Part 1: Muscle impairments or diseases due to the frailty induced by sarcopenia

Chapter 16 Declines in whole muscle function with aging: the role of age-related alterations in contractile properties of single skeletal muscle fibres

Nicole Mazara and Geoffrey A. Power

Chapter 17 Sarcopenic dysphagia, presbyphagia and rehabilitation nutrition

Hidetaka Wakabayashi and Kunihiro Sakuma

Part 2: Complications due to sarcopenia in acute or chronic diseases

Chapter 18 Wasting and cachexia in chronic kidney disease

Giacomo Garibotto, Daniela Picciotto and Daniela Verzola

Chapter 19 Sarcopenia and Parkinson's disease: molecular mechanisms and clinical management

Manlio Vinciguerra

Chapter 20 Sarcopenic obesity in the elderly

Michael Tieland, Inez Trouwborst, Amely Verreijen et al

Chapter 21 Sum up and future research

Dominique Meynial-Denis

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Dominique Meynial-Denis studied Biochemistry and Molecular Biology at the University Paul Sabatier of Toulouse, France and obtained her Ph.D. degree on intermolecular interactions between drug and plasma proteins followed by magnetic resonance spectroscopy (MRS) at the same University in 1985. Since 1986, she has worked as a scientist at the National Institute of Agricultural Research (INRA) in Clermont-Ferrand in a Department focussing on Human Nutrition. Consequently, she became a Nutritionist and specialised her research on Sarcopenia and Aging in 1994. She applied MRS to metabolic pathways of amino acids in muscle during aging. Dominique Meynial-Denis received a second Ph.D. in 1998 on amino acid fluxes throughout skeletal muscle during aging. More recently, she has mainly been interested in the effect of glutamine supplementation in advanced age. She is a member of the French Society of Enteral and Parenteral Nutrition (SFNEP), of the European Society of Clinical Nutrition and Metabolism (ESPEN), of the Société Française de Nutrition (SFN), of the International Association of Gerontology and Geriatrics (IAGG) and of the Société Francophone de Gérontologie et Gériatrie (SFGG). She is a regular referee to different international journals on Nutrition as well as Aging.


'This book reflects the evolving research on sarcopenia and its fundamental applications. The purpose is to present a comprehensive review of research in the field of sarcopenia. Instead of having to read through hundreds of journal articles on sarcopenia, readers can find a chapter with up-to-date summaries of evidence-based medicine and research in this book.

'Physicians, medical students, nutritionists, and non-clinical sarcopenia researchers will find this book helpful. It is written at a high scientific
level and expects readers have baseline knowledge of sarcopenia. The author and contributors write at a level for their colleagues or peers. The chapters on molecular and cellular aspects of sarcopenia are challenging but eye opening for clinicians who do not work in lab settings. The chapters on clinical findings and management will be more readily understood by all. The result is a well-rounded, applicable knowledge of sarcopenia, brought to life by leading international sarcopenia researchers.

'No other sarcopenia book on the market that I have read compares to this one. It is comprehensive but not overwhelming, futuristic but applicable. The most unique feature is the author's ability to link multiple scientific disciplines from molecular biology to nutrition to explain one of the most prevalent and destructive syndromes in aging.'

Weighted Numerical Score: 88 - 3 Stars

-- Issam el bizri, Dartmouth Geisel School of Medicine