Sarcopenia: Molecular, Cellular, and Nutritional Aspects – Applications to Humans, 1st Edition (Hardback) book cover


Molecular, Cellular, and Nutritional Aspects – Applications to Humans, 1st Edition

Edited by Dominique Meynial-Denis

CRC Press

432 pages | 8 Color Illus. | 42 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9781498765138
pub: 2019-12-02
SAVE ~$40.00
eBook (VitalSource) : 9780429155260
pub: 2019-11-20
from $100.00

FREE Standard Shipping!


Sarcopenia: Molecular, Cellular, and Nutritional Aspects describes the progressive loss of skeletal muscle mass and strength, defined by Rosenberg in 1997 as a hallmark of aging and referred to as “sarcopenia”. As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. The condition worsens in the presence of chronic diseases that accelerate its progression. Sarcopenia is not considered to be “a process of normative aging” but according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM), as a disease. As sarcopenia is an unavoidable process, prevention and management are the only options to promote healthy aging, actions that should perhaps should perhaps be taken during youth.

Included in this book:

· Features essential information on sarcopenia, its current definition, and molecular and cellular aspects of this disease

· Discusses the development of physical frailty, a complication of sarcopenia, and predicts its occurrence in the older population

· Presents alterations in muscle protein turnover and mitochondrial dysfunction in the aging process

· Provides data on the negative involvement of sarcopenia in certain chronic diseases that can lead to cachexia, a metabolic wasting syndrome

· Describes presbyphagia or age-related changes in the swallowing mechanism in older people

· Details possible strategies to combat muscle wasting in healthy older adults and their limitations

This book features information collected from pioneers or experts on human aging from around the globe, including Europe, Brazil, Canada, Japan and the United States. It is a valuable source of information for nutritional scientists, medical doctors, sports scientists, food scientists, dietitians, students in these fields, and for anyone interested in nutrition. We hope this book provides a better understanding of sarcopenia which inevitably occurs with aging without weight loss. The book also provides information outlining strategies to prevent or limit muscle wasting due to normal aging in order to promote successful aging.

Table of Contents


Naji Abumrad

Division of General Surgery, Vanderbilt University Medical Center

Basics of sarcopenia: definition and challenges of sarcopenia research

Chapter 1 Definitions of Sarcopenia

Heike Bischoff-Ferrari1 and Bess Dawson-Hughes2

1Dept. of Geriatrics and Aging Research, University of Zurich and University Hospital of Zurich, Switzerland

2Jean Mayer USDA Human Nutrition Research Center on Aging, Bone Metabolism Laboratory, Tufts University, Boston, Massachusetts


New data on sarcopenia

2 Models of Accelerated Sarcopenia

Andrew S. Layne1, Lisa M. Roberts2 and Thomas W. Buford2 1University of Florida, Gainesville, USA

2University of Alabama at Birmingham, Birmingham, AL

3 Sarcopenia in physical frailty

Maturin Tabue-Teguo1,2, Emanuele Marzetti3, Riccardo Calvani3,4, Bruno Vellas5,6, Matteo Cesari7,8

1CHU de Guadeloupe, Université des Antilles

2INSERM 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France

3Fondazione Policlinico Universitario "Agostino Gemelli" IRCSS, 00168 Rome, Italy.

4Università Cattolica del Sacro Cuore, Institute of Internal Medicine and Geriatrics, 00168 Rome, Italy

5Gérontopôle, Centre Hospitalier Universitaire de Toulouse,

6INSERM UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France

7Geriatric Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milano, Italy

8Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy


Molecular and cellular aspects of sarcopenia

4 The role of imaging techniques in the diagnosis of sarcopenia

Thiago Gonzalez Barbosa-Silva1and Carla Prado2

1Department of Surgery, Faculty of Medicine, Federal University of Pelotas; Department of Ginecology & Obstetrics, Faculty of Medicine, Catholic University of Pelotas (Pelotas, Brazil);

2Human Nutrition Research Unit, Department of Agricultural, Food and Nutritional Science, University of Alberta (Edmonton, Canada)

5 Nutrient Sensing and mTORC1 Regulation in Sarcopenia

Ted G. Graber and Blake B. Rasmussen

Lloyd and Sue Ann Hill, Department of Nutrition & Metabolism, University of Texas, Medical Branch, Galveston, USA

6 Different adaptation of ubiquitin-proteasome and lysosome-autophagy signaling in sarcopenic muscle

Kunihiro Sakuma1, Hidetaka Wakabayashi2

1Institute for Liberal Arts, Environment and Society, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan,

2Department of Rehabilitation Medicine, Yokohama City University Medical Center, Yokohama city, Japan,

7 Myokines in aging muscle

Katie Brown, Aaron Persinger, and Melissa Puppa, PhD

The University of Memphis, 306 Elma Roane Fieldhouse,

Memphis, TN 38152

8 The contribution of satellite cells to skeletal muscle aging

Christopher Fry

Department of Nutrition and Metabolism,

University of Texas Medical Branch,

Galveston, USA

9 Muscle stem cell microenvironment in sarcopenia

Neia Naldaiz-Gastesi1,2,3, and Ander Izeta1,4,*

1 Tissue Engineering group, Instituto Biodonostia, San Sebastian, Spain

2 Neuromuscular diseases group, Instituto Biodonostia, San Sebastian, Spain

3 CIBERNED, Instituto de Salud Carlos III, Madrid, Spain

4 Department of Biomedical Engineering and Science, School of Engineering, Tecnun-University of Navarra, San Sebastian, Spain.

10 Sarcopenia and Oxidative stress: from the bench to therapeutical strategies

Coralie Arc-Chagnaud1-2, Allan F. Pagano3, Thomas Brioche1

1 Université de Montpellier, INRA, UMR 866 Dynamique Musculaire et Métabolisme, F-34060, Montpellier

2Freshage Research Group - Dept. Physiology - University of Valencia, CIBERFES, INCLIVA, Valencia, Spain

3 Université de Strasbourg, Faculté des Sciences du Sport, EA3072 "Mitochondries, Stress Oxydant et Protection Musculaire, Strasbourg, France


Alterations in muscle protein turnover in the aging process

11 Muscle protein turnover and sarcopenia in the elderly: the effects of nutrition

Paolo Tessari

Department of Medicine, University of Padova, via Giustiniani 2, 35128, Padua, Italy

12 The relationship between muscle mitochondrial turnover and sarcopenia

Heather N. Carter, Nashwa Cheema and David A. Hood

Muscle Health Research Centre, School of Kinesiology and Health Science, York University, Toronto, Ontario, M3J 1P3, Canada.

13 Skeletal muscle fat infiltration with aging: an important factor of sarcopenia

Allan F. Pagano1, 2, Coralie Arc-Chagnaud2, 3, Thomas Brioche2, Angèle Chopard2,Guillaume Py2

1Université de Strasbourg, Faculté des Sciences du Sport, EA3072 "Mitochondries, Stress Oxydant et Protection Musculaire, Strasbourg, France

2Université de Montpellier, INRA, UMR866 Dynamique Musculaire et Métabolisme, F-34060, Montpellier, France

3Freshage Research Group - Dept. Physiology - University of Valencia, CIBERFES, INCLIVA, Valencia, Spain.


Recent advances limiting sarcopenia and supporting healthy aging

14 Nutritional modulation of mitochondrial-associated death signaling in sarcopenia

Stephen E. Alway

Laboratory of Muscle Biology and Sarcopenia

Department of Physical Therapy, College of Health Professions

and Department of Physiology, College of Medicine

930 Madison Avenue, Suite 622

The University of Tennessee Health Science Center, Memphis TN 38163

15 Beneficial effects and limitations of strategies (nutritional or other) to limit muscle wasting due to normal aging

Dominique Meynial-Denis

UNH, UMR 1019, INRA, CRNH Auvergne, Clermont-Ferrand, France



Part 1: Muscle impairments or diseases due to the frailty induced by sarcopenia

16 Declines in whole muscle function with aging: the role of age-related alterations in contractile properties of single skeletal muscle fibres

Nicole Mazara and Geoffrey A. Power

Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada

17 Sarcopenic dysphagia, presbyphagia and rehabilitation nutrition

Hidetaka Wakabayashi1 and Kunihiro Sakuma2

1Department of Rehabilitation Medicine, Yokohama City University Medical Center

4-57 Urafune-chou, Minami ward, Yokohama city, Japan 232-0024

2Institute for Liberal Arts, Environment and Society, Tokyo Institute of Technology

2-12-1 Ookayama, Meguro ward, Tokyo, Japan 152-8550

Part 2: Complications due to sarcopenia in acute or chronic diseases

18 Wasting and cachexia in chronic kidney disease

Giacomo Garibotto, Daniela Picciotto, Daniela Verzola

Division of Nephrology, Dialysis and Transplantation, University of Genoa, Italy and IRCCS Ospedale Policlinico San Martino, Italy

19 Sarcopenia and Parkinson's disease: molecular mechanisms and clinical management

Manlio Vinciguerra12

1Center for Translational Medicine (CTM), International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czech Republic;

2Division of Medicine, University College London (UCL), London, UK.

UCL Institute for Liver and Digestive Health, Division of Medicine, London, UK

20 Sarcopenic obesity in the elderly

Michael Tieland1, Inez Trouwborst1, Amely Verreijen1, Robert Memelink1 and Peter J.M. Weijs1,2

1Department of Nutrition and Dietetics, Faculty of Sports and Nutrition, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands

2Department of Nutrition and Dietetics, Amsterdam University Medical Centers, Amsterdam, The Netherlands

21 Sum up and future research

Dominique Meynial-Denis

UNH, UMR 1019, INRA, CRNH Auvergne, Clermont-Ferrand, France

About the Editor

Dominique Meynial-Denis studied Biochemistry and Molecular Biology at the University Paul Sabatier of Toulouse, France and obtained her Ph.D. degree on intermolecular interactions between drug and plasma proteins followed by magnetic resonance spectroscopy (MRS) at the same University in 1985. Since 1986, she has worked as a scientist at the National Institute of Agricultural Research (INRA) in Clermont-Ferrand in a Department focussing on Human Nutrition. Consequently, she became a Nutritionist and specialised her research on Sarcopenia and Aging in 1994. She applied MRS to metabolic pathways of amino acids in muscle during aging. Dominique Meynial-Denis received a second Ph.D. in 1998 on amino acid fluxes throughout skeletal muscle during aging. More recently, she has mainly been interested in the effect of glutamine supplementation in advanced age. She is a member of the French Society of Enteral and Parenteral Nutrition (SFNEP), of the European Society of Clinical Nutrition and Metabolism (ESPEN), of the Société Française de Nutrition (SFN), of the International Association of Gerontology and Geriatrics (IAGG) and of the Société Francophone de Gérontologie et Gériatrie (SFGG). She is a regular referee to different international journals on Nutrition as well as Aging.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Geriatrics
MEDICAL / Nutrition
SCIENCE / Life Sciences / Biology / Molecular Biology