Scale-Up and Optimization in Preparative Chromatography: Principles and Biopharmaceutical Applications, 1st Edition (Hardback) book cover

Scale-Up and Optimization in Preparative Chromatography

Principles and Biopharmaceutical Applications, 1st Edition

Edited by Anurag Rathore, Ajoy Velayudhan

CRC Press

368 pages

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Hardback: 9780824708269
pub: 2002-09-26
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Description

Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; data comparisons from all stages of production; and industrial separation schemes for products such as synthetic molecules, antibody fragments, IgG, growth factors, and plasmid DNA. The book covers external constraints, separation economics, correlations for transport and kinetic phenomena, and the configuration and parameters of column design.

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI013060
SCIENCE / Chemistry / Industrial & Technical