This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophoresis and therapeutic drug monitoring for improved productivity, precision, and safety in clinical chemistry, biomedical analysis, and forensic research.
From saliva, hair, and biological samples to illegal drugs and toxins, Separation Techniques in Clinical Chemistry is a thorough single-source guide for analytical, organic, pharmaceutical, medicinal, physical, surface, and colloid chemists and biochemists; and upper-level undergraduate and graduate students in these disciplines.
Table of Contents
Sample pretreatment in clinical chemistry, I.N. Papadonoyannis and V.F. Samanidou; the separation science in therapeutic drug monitoring, Zak K. Shihabi; the impact of chirality in pharmacokinetics and therapeutic drug monitoring, Karla A. Moore and Barry Levine; HPLC in bioavailability examination, Zdzislaw Chilmonczyk, Kamila Kobyliska, and Hassan Y. Aboul-Enein; validation of HPLC analyses in therapeutic drug monitoring, Zdzislaw Chilmonczyk, Iwona Cendrowsk and Hassan Y. Aboul-Enein; analysis of illicit drugs with chromatography, M.J. Bogusz; biogenic amine neurotransmitters - their importance and measurement in human tissue and body fluids, Adarsh M. Kumar; clinical applications of affinity chromatography, William Clarke and David S. Hage; immunoaffinity chromatography in clinical analysis, David S. Hage and William Clarke; electrospray tandem mass spectrometry in biochemical genetics laboratory, Mohamed S. Rashed; application of thin-layer chromatography, Jan Bladek and Slawomir Neffe; applications of capillary electrophoresis in clinical analysis of drugs, Jacek Bojarski and Joanna Szymura-Oleksiak.