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Signal Transduction and Smooth Muscle





ISBN 9780367657079
March 30, 2021 Forthcoming by CRC Press
412 Pages

 
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Book Description

All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling.



 



Key selling features:





  • Focuses on smooth muscles of different types


  • Describes ion channel signaling mechanisms


  • Reviews calcium and receptor signaling


  • Includes novel, cutting-edge methodologies


  • Summarizes studies of mice with genetically encoding sensors in smooth muscle


Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498774222_oachapter9.pdf

Table of Contents



Series Preface



Preface



Editors



Contributors





Chapter 1 Elucidation of Vasopressin Signal Transduction Pathways in Vascular Smooth Muscle



Kenneth L. Byron and Lyubov I. Brueggemann





Chapter 2 Investigating Chloride Channels in Smooth Muscle



Henry R. Askew Page and Iain A. Greenwood





Chapter 3 Methods for the Isolation of and Study of Ca2+ Signaling in Arteriolar Smooth Muscle Cells



William F. Jackson





Chapter 4 Ion Channel Trafficking in Arterial Smooth Muscle Cells and Functional Significance



M. Dennis Leo and Jonathan H. Jaggar





Chapter 5 Total Internal Reflection Fluorescence Microscopy in Vascular Smooth Muscle



Madeline Nieves-Cintrón, Sendoa Tajada, L. Fernando Santana, and Manuel F. Navedo





Chapter 6 T-Type Ca2+ Channels in Vascular Smooth Muscle: Properties, Regulation, and Function



Osama F. Harraz, Ahmed M. Hashad, and Donald G. Welsh





Chapter 7 Calcium Sensitization in Smooth Muscle Involving Regulation of Myosin Light Chain Phosphatase Activity



Justin A. MacDonald, Michael P. Walsh, and William C. Cole





Chapter 8 Approaches for Investigating the Functional Significance of Transient Receptor Potential Cation Channels in Smooth Muscle Cells



Harry A. T. Pritchard, Paulo W. Pires, and Scott Earley





Chapter 9 Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells



John G. McCarron, Christopher Saunter, Calum Wilson, John M. Girkin, and Susan Chalmers





Chapter 10 ORAI Channels in Vascular Smooth Muscle



Maxime Guéguinou, Xuexin Zhang, Trayambak Pathak, Scott Emrich, Ryan Yoast, and Mohamed Trebak





Chapter 11 G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung Disease



Tonio Pera and Raymond B. Penn





Chapter 12 Brain-Derived Neurotrophic Factor in Airway Smooth Muscle: Contributions to Asthma



Michael Thompson, Rodney Britt Jr, Anne Roesler, Katelyn Cummings, Christina M. Pabelick, and Y. S. Prakash





Chapter 13 Antibody-Based Approaches for Protein Analysis of Smooth Muscles



Brian A. Perrino and Yeming Xie





Chapter 14 Role of Ion Channels in Urinary Bladder Smooth Muscle Function



Georgi V. Petkov





Chapter 15 Methods for Investigating the Regulation of Smooth Muscle Excitability by Interstitial Cells



Bernard T. Drumm and Kenton M. Sanders





Chapter 16 Electrical Pacemaking in Lymphatic Vessels



Scott D. Zawieja, Jorge A. Castorena-Gonzalez, Kim H. T. To, Peichun Gui, Timothy Domeier, and Michael J. Davis





Chapter 17 NADPH Oxidase, Redox Signaling, and Vascular Smooth Muscle Function



Daniel S. de Jesus, Eugenia Cifuentes-Pagano, Sanghamitra Sahoo, and Patrick J. Pagano





Index

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Editor(s)

Biography



Mohamed Trebak is Professor of Cellular and Molecular Physiology at the Penn State Hershey College of Medicine.



Scott Earley is Associate Professor of Pharmacology at the University of Nevada Reno.

Support Material

Open Access Content

  • Chapter 9 (.pdf) Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells John G. McCarron, Christopher Saunter, Calum Wilson, John M. Girkin, and Susan Chalmers

    Open Access content has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives (CCBY-NC-ND) license