Signal Transduction and Smooth Muscle  book cover
1st Edition

Signal Transduction and Smooth Muscle

ISBN 9780367657079
Published March 30, 2021 by CRC Press
432 Pages

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Book Description

All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling.


Key selling features:

  • Focuses on smooth muscles of different types

  • Describes ion channel signaling mechanisms

  • Reviews calcium and receptor signaling

  • Includes novel, cutting-edge methodologies

  • Summarizes studies of mice with genetically encoding sensors in smooth muscle

Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license.

Table of Contents

Series Preface




Chapter 1 Elucidation of Vasopressin Signal Transduction Pathways in Vascular Smooth Muscle

Kenneth L. Byron and Lyubov I. Brueggemann

Chapter 2 Investigating Chloride Channels in Smooth Muscle

Henry R. Askew Page and Iain A. Greenwood

Chapter 3 Methods for the Isolation of and Study of Ca2+ Signaling in Arteriolar Smooth Muscle Cells

William F. Jackson

Chapter 4 Ion Channel Trafficking in Arterial Smooth Muscle Cells and Functional Significance

M. Dennis Leo and Jonathan H. Jaggar

Chapter 5 Total Internal Reflection Fluorescence Microscopy in Vascular Smooth Muscle

Madeline Nieves-Cintrón, Sendoa Tajada, L. Fernando Santana, and Manuel F. Navedo

Chapter 6 T-Type Ca2+ Channels in Vascular Smooth Muscle: Properties, Regulation, and Function

Osama F. Harraz, Ahmed M. Hashad, and Donald G. Welsh

Chapter 7 Calcium Sensitization in Smooth Muscle Involving Regulation of Myosin Light Chain Phosphatase Activity

Justin A. MacDonald, Michael P. Walsh, and William C. Cole

Chapter 8 Approaches for Investigating the Functional Significance of Transient Receptor Potential Cation Channels in Smooth Muscle Cells

Harry A. T. Pritchard, Paulo W. Pires, and Scott Earley

Chapter 9 Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells

John G. McCarron, Christopher Saunter, Calum Wilson, John M. Girkin, and Susan Chalmers

Chapter 10 ORAI Channels in Vascular Smooth Muscle

Maxime Guéguinou, Xuexin Zhang, Trayambak Pathak, Scott Emrich, Ryan Yoast, and Mohamed Trebak

Chapter 11 G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung Disease

Tonio Pera and Raymond B. Penn

Chapter 12 Brain-Derived Neurotrophic Factor in Airway Smooth Muscle: Contributions to Asthma

Michael Thompson, Rodney Britt Jr, Anne Roesler, Katelyn Cummings, Christina M. Pabelick, and Y. S. Prakash

Chapter 13 Antibody-Based Approaches for Protein Analysis of Smooth Muscles

Brian A. Perrino and Yeming Xie

Chapter 14 Role of Ion Channels in Urinary Bladder Smooth Muscle Function

Georgi V. Petkov

Chapter 15 Methods for Investigating the Regulation of Smooth Muscle Excitability by Interstitial Cells

Bernard T. Drumm and Kenton M. Sanders

Chapter 16 Electrical Pacemaking in Lymphatic Vessels

Scott D. Zawieja, Jorge A. Castorena-Gonzalez, Kim H. T. To, Peichun Gui, Timothy Domeier, and Michael J. Davis

Chapter 17 NADPH Oxidase, Redox Signaling, and Vascular Smooth Muscle Function

Daniel S. de Jesus, Eugenia Cifuentes-Pagano, Sanghamitra Sahoo, and Patrick J. Pagano


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Mohamed Trebak is Professor of Cellular and Molecular Physiology at the Penn State Hershey College of Medicine.

Scott Earley is Associate Professor of Pharmacology at the University of Nevada Reno.