1st Edition

Signal Transduction and Smooth Muscle

Edited By Mohamed Trebak, Scott Earley Copyright 2019
    432 Pages
    by CRC Press

    432 Pages 32 Color & 39 B/W Illustrations
    by CRC Press

    432 Pages 32 Color & 39 B/W Illustrations
    by CRC Press

    All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling.


    Key selling features:

    • Focuses on smooth muscles of different types

    • Describes ion channel signaling mechanisms

    • Reviews calcium and receptor signaling

    • Includes novel, cutting-edge methodologies

    • Summarizes studies of mice with genetically encoding sensors in smooth muscle

    Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498774222_oachapter9.pdf

    Series Preface




    Chapter 1 Elucidation of Vasopressin Signal Transduction Pathways in Vascular Smooth Muscle

    Kenneth L. Byron and Lyubov I. Brueggemann

    Chapter 2 Investigating Chloride Channels in Smooth Muscle

    Henry R. Askew Page and Iain A. Greenwood

    Chapter 3 Methods for the Isolation of and Study of Ca2+ Signaling in Arteriolar Smooth Muscle Cells

    William F. Jackson

    Chapter 4 Ion Channel Trafficking in Arterial Smooth Muscle Cells and Functional Significance

    M. Dennis Leo and Jonathan H. Jaggar

    Chapter 5 Total Internal Reflection Fluorescence Microscopy in Vascular Smooth Muscle

    Madeline Nieves-Cintrón, Sendoa Tajada, L. Fernando Santana, and Manuel F. Navedo

    Chapter 6 T-Type Ca2+ Channels in Vascular Smooth Muscle: Properties, Regulation, and Function

    Osama F. Harraz, Ahmed M. Hashad, and Donald G. Welsh

    Chapter 7 Calcium Sensitization in Smooth Muscle Involving Regulation of Myosin Light Chain Phosphatase Activity

    Justin A. MacDonald, Michael P. Walsh, and William C. Cole

    Chapter 8 Approaches for Investigating the Functional Significance of Transient Receptor Potential Cation Channels in Smooth Muscle Cells

    Harry A. T. Pritchard, Paulo W. Pires, and Scott Earley

    Chapter 9 Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells

    John G. McCarron, Christopher Saunter, Calum Wilson, John M. Girkin, and Susan Chalmers

    Chapter 10 ORAI Channels in Vascular Smooth Muscle

    Maxime Guéguinou, Xuexin Zhang, Trayambak Pathak, Scott Emrich, Ryan Yoast, and Mohamed Trebak

    Chapter 11 G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung Disease

    Tonio Pera and Raymond B. Penn

    Chapter 12 Brain-Derived Neurotrophic Factor in Airway Smooth Muscle: Contributions to Asthma

    Michael Thompson, Rodney Britt Jr, Anne Roesler, Katelyn Cummings, Christina M. Pabelick, and Y. S. Prakash

    Chapter 13 Antibody-Based Approaches for Protein Analysis of Smooth Muscles

    Brian A. Perrino and Yeming Xie

    Chapter 14 Role of Ion Channels in Urinary Bladder Smooth Muscle Function

    Georgi V. Petkov

    Chapter 15 Methods for Investigating the Regulation of Smooth Muscle Excitability by Interstitial Cells

    Bernard T. Drumm and Kenton M. Sanders

    Chapter 16 Electrical Pacemaking in Lymphatic Vessels

    Scott D. Zawieja, Jorge A. Castorena-Gonzalez, Kim H. T. To, Peichun Gui, Timothy Domeier, and Michael J. Davis

    Chapter 17 NADPH Oxidase, Redox Signaling, and Vascular Smooth Muscle Function

    Daniel S. de Jesus, Eugenia Cifuentes-Pagano, Sanghamitra Sahoo, and Patrick J. Pagano



    Mohamed Trebak is Professor of Cellular and Molecular Physiology at the Penn State Hershey College of Medicine.

    Scott Earley is Associate Professor of Pharmacology at the University of Nevada Reno.