Signaling by Toll-Like Receptors: 1st Edition (Hardback) book cover

Signaling by Toll-Like Receptors

1st Edition

Edited by Gregory W. Konat

CRC Press

224 pages | 2 Color Illus. | 19 B/W Illus.

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Hardback: 9781420043181
pub: 2008-06-20
eBook (VitalSource) : 9780429139130
pub: 2008-06-20
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The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.

Table of Contents

Assessing the Response of Cells to TLR Stimulation, K. Takeda, M. Yamamoto, and K. Honda

TLR Ligands in Experimental Settings: Their Purity and Specificity, M.F.Tsan

Analysis of TLR Expression, Regulation, and Signaling, H. Xiao, X. Li, and D.W. Abbott

Intracellular Trafficking of Toll-Like Receptors, H. Husebye, Ø. Halaas, H. Stenmark, and T. Espevik

The Role of Small RhoGTPases in TLR Signaling, M. Ruse and U.G. Knaus

Use of Engineered β-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors, H.-K. Lee and P.S. Tobias

Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling, T. Nishiya and A.L. DeFranco

Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling, C.-S. Shi and J.H. Kehrl

Role of Toll-Like Receptor Signaling in Central Nervous System Infections, T. Kielian

The Influence of Injury on Toll-Like Receptor Responses, T.J. Murphy, A.A. Maung, H.M. Paterson, and J.A. Lederer


About the Authors/Editor

Gregory W. Konat

About the Series

Methods in Signal Transduction Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Immunology
SCIENCE / Life Sciences / Cytology
SCIENCE / Research & Methodology