224 pages | 2 Color Illus. | 19 B/W Illus.
The discovery of toll-like receptors (TLRs) spurred the field of innate immunity into a renaissance after many years of neglect. Since then, TLR research has grown at an exponential rate. Taking an integrated methodological approach, Signaling by Toll-Like Receptors offers a comprehensive review of important techniques in molecular biology, cell biology, biochemistry, genetics, and immunology and their critical application to the study of toll-like receptor structure, biological function, and the intracellular signaling triggered by these receptors.
Assessing the Response of Cells to TLR Stimulation, K. Takeda, M. Yamamoto, and K. Honda
TLR Ligands in Experimental Settings: Their Purity and Specificity, M.F.Tsan
Analysis of TLR Expression, Regulation, and Signaling, H. Xiao, X. Li, and D.W. Abbott
Intracellular Trafficking of Toll-Like Receptors, H. Husebye, Ø. Halaas, H. Stenmark, and T. Espevik
The Role of Small RhoGTPases in TLR Signaling, M. Ruse and U.G. Knaus
Use of Engineered β-Lactamase Fragment Complementation to Detect the Associations of Toll-Like Receptors and Signaling Adaptors, H.-K. Lee and P.S. Tobias
Use of Toll-Like Receptor Chimeras to Dissect Mechanisms of Receptor Localization and Signaling, T. Nishiya and A.L. DeFranco
Engagement of Toll-Like Receptors Modulates Chemokine Receptor Signaling, C.-S. Shi and J.H. Kehrl
Role of Toll-Like Receptor Signaling in Central Nervous System Infections, T. Kielian
The Influence of Injury on Toll-Like Receptor Responses, T.J. Murphy, A.A. Maung, H.M. Paterson, and J.A. Lederer