Single-Molecule Tools for Bioanalysis
- Available for pre-order. Item will ship after September 30, 2021
In the last three decades, the fast development of single-molecule techniques has revolutionized the way we observe and understand biological processes. Some of these techniques have been further adapted as tools for bioanalysis. This book summarizes and details the frontiers of the development of these tools as well as their applications. All chapter contributors are young but established researchers in their respective fields. The main content also forms the lecture notes of a chemistry graduate course in charge of the book editor, Prof. Shuo Huang, at Nanjing University. This book is suitable to be used as a textbook for a high-level undergraduate or an entry-level graduate course. The systematically written content provides a thorough illustration of the mechanisms of each methodology presented.
Table of Contents
1. Single-Molecule Analysis by Biological Nanopores
2. Optical Tweezers for the Manipulation of Single Molecules
3. Single-Molecule Biosensing by Fluorescence Resonance Energy Transfer (FRET)
4. DNA Origamis as Single-Molecule Biosensors
5. Single-Molecule Manipulation by Magnetic Tweezers
6. Long-Time Recording of Single-Molecule Dynamics in Solution by Anti-Brownian Trapping
Shuo Huang obtained his BS in physics from Nanjing University in 2006 and his PhD in biophysics from Arizona State University in 2011. From 2011 to 2015, he was a postdoctoral fellow at the University of Oxford. In 2015, Prof. Huang joined Nanjing University, China, where he is professor at the School of Chemistry and Chemical Engineering. His research focuses on the development of single-molecule sensing tools based on biological nanopores.