Sleep Apnea: Pathogenesis, Diagnosis and Treatment, 2nd Edition (Hardback) book cover

Sleep Apnea

Pathogenesis, Diagnosis and Treatment, 2nd Edition

Edited by Allan I. Pack

CRC Press

558 pages | 187 B/W Illus.

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Sleep apnea is a common chronic condition affecting millions of people. Written by a multidisciplinary team including sleep medicine specialists, pulmonologists, scientists, psychiatrists, otorhinolaryngologists, and more, this text provides essential scientific and clinical information for those treating and researching the condition.

Since the previous edition published, sleep medicine has become a fully formed medical speciality. This second edition has been expanded to contain more clinically relevant information regarding diagnosis and treatment, and includes:

  • New developments regarding the cardiovascular effects of sleep apnea
  • New developments regarding the role of sleep apnea in insulin resistance
  • Developing research on intermittent hypoxia in the disorder
  • Latest pharmacotherapeutic trials, addressed in the last chapter

Organized into sections and subsections to make the book easier for the reader to use, this essential text also examines sleep apnea in special populations, such as children, older adults or pregnant women, and takes into account gender differences in the disorder.

Table of Contents



Pathogenesis of obstructive sleep apnea: Insights from upper airway imaging studies, Murtuza M. Ahmed and Richard J. Schwab

Biomechanics of the upper airway during sleep, Philip L. Smith, Jason P. Kirkness, Susheel Patil, Hartmut Schneider, and Alan R. Schwartz

Neural mechanisms

Sleep-induced breathing instability, Ailiang Xie, Curtis A. Smith, and Jerome A. Dempsey

Mechanisms of upper airway hypotonia, Leszek Kubin and Richard O. Davies

Autonomic consequences of arousal from sleep and neural mechanisms of arousal, Richard L. Horner


Studies in humans

Airway reflexes: Changes with sleep, David P. White

Gender differences in sleep-disordered breathing, M. Safwan Badr and Jason H. Mateika



Mechanisms of sleepiness in obstructive sleep apnea, Mark S. Aloia and J. Todd Arnedt

Neuroimaging studies in obstructive sleep apnea, Liat Ayalon and Sean P. A. Drummond

Biomarkers and obstructive sleep apnea, Erna Sif Arnardottir, Bernie Sunwoo, and Allan I. Pack

Cardiovascular consequences

Obstructive sleep apnea and hypertension: Interactions and clinical implications, Suraj Kapa, Apoor S. Gami, and Virend K. Somers

Other cardiovascular consequences of sleep apnea, Julio A. Chirinos, Frederick F. Samaha, and Mark H. Sanders


Neuroendocrine aspects of sleep apnea, Brendon J. Yee, Peter Y. Liu, Craig Phillips, and Ronald R. Grunstein

Obstructive sleep apnea and glucose metabolism, Jan Polak, Brock A. Beamer, and Naresh M. Punjabi

Intermittent hypoxia

Intermittent hypoxia and neurocognitive function, David Gozal, Leila Kheirandish-Gozal, Yang Wang, and Shelley X. L. Zhang

Obstructive sleep apnea: Mechanisms of intermittent hypoxemia neural injury, Sigrid C. Veasey

Diagnosis of sleep apnea

Screening for sleep apnea, Indira Gurubhagavatula

Alternative strategies for diagnosis of patients with obstructive sleep apnea, Samuel T. Kuna

Sleep apnea in specialized groups

Obstructive sleep apnea: Children versus adults, Eliot S. Katz and Carole L. Marcus

Sleep apnea in older adults, Nalaka S. Gooneratne

Obstructive sleep apnea in pregnancy and menopause, Grace W. Pien

Treatment of sleep apnea

Adherence to CPAP treatment and functional status in adult obstructive sleep apnea, Terri E. Weaver, Judith Reishtein, and Amy M. Sawyer

CPAP therapy: Results of randomized controlled trials in obstructive sleep apnea, Sophie D. West and John R. Stradling

Oral appliance therapy for snoring and sleep apnea, Peter A. Cistulli and Ali M. Darendeliler

Upper airway surgery for obstructive sleep apnea, Edward M. Weaver and Andrew N. Goldberg|

Pharmacotherapeutic trials for sleep-disordered breathing, Jan Hedner, Ludger Grote, and Ding Zou

Index 551

About the Series

Lung Biology in Health and Disease

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Internal Medicine
MEDICAL / Neurology
MEDICAL / Pulmonary & Thoracic Medicine