Small Molecules in Neurodegeneration

1                     Introduction to Neurodegenerative Diseases         

Urmilla John, Javeed Ahmad Bhat, Nawab John Dar, and Shahnawaz Ali Bhat

2                     Small molecules: An emerging therapeutic frontier

Urmilla John, Nawab John Dar, and Shahnawaz Ali Bhat

3                     Small molecules in multiple sclerosis: An update

Insha Zahoor, Urmillah John, and Nawab John Dar

4                     Andrographolide in Neurological Disorders: a detailed overview

Bisma Gul, Mir Mohd Faheem, Zabeer Ahmed, and Muzamil Ahmad

5                     Natural Products as Neuroprotective Agents         

Dipak Kumar and Abhishek Kumar Mishra

6                     Medicinal Chemistry and the Design of Small Molecules  

Faheem Rasool and Nawab John Dar

7                     Neurotrophic Factors and Small Molecule Mimetics          

Ishtiaq Jeelani, Aamir Sharif, Urmilla John, Alisha Sheikh, Saeed Ahmed, and Allah Nawaz

8                     Repurposed Drugs: Expanding the Therapeutic Resource 

Duilio Cervantes and Aida Adlimoghaddam

9                     Integrating Small Molecules into Multimodal Treatment Strategies

Sakshi Patel, Prem Shankar Mishra, S.K. Abdul Rahaman. Rahul Kumar, Mudassir Jan Makhdoomi, and Abid Ali Sheikh

10                  Advances in Small Molecule Delivery Systems for the Treatment of Neurodegenerative Disease            

Nargis Bano, Sameera Khan, Shakir Ahamad, Faaizah Fazal, Nawab John Dar, and Shahnawaz Ali Bhat

11                  An Enigmatic role of Small Molecule Therapeutics in Neurodegeneration.   

Rukhsana Hassan,Feroze Ahmad Mir, Umeair Kazime, Aarizo Tabasum, Sajad Ahmad Bhat, Mir Mohammad Hussain, Mushtaq Ahmad,  Gh Nabi Bhat, and Gh Rasool Bhat

12                  Bridging the Gap in Neurodegenerative Disease Therapy (NDT)     

Shikha Sharma, Showkat Dar, and Nawab John Dar

13                  Ethical and Economic Considerations in Small Molecule Therapy 

Sameer A Mir, Urmilla John, and Nawab John Dar

Biography

Dr. Nawab John Dar is at the Salk Institute for Biological Studies in La Jolla, California, where he is part of a research group led by Professor Pamela Maher. His research journey began after graduating from the CSIR-Indian Institute of Integrative Medicine in India, and he has since been dedicated to advancing the understanding of neurodegenerative disorders, particularly Alzheimer’s disease. Dr. Dar's work focuses on exploring the neuroprotective potential of bioactive compounds and investigating the role of oxytosis/ferroptosis in Alzheimer’s disease. His goal is to identify targets for effective therapies against Alzheimer’s. Beyond his scientific endeavors, Dr. Dar is a committed educator and advocate for raising awareness about neurodegenerative diseases, emphasizing the importance of small molecules in targeting various aspects of neurodegeneration. His work not only sheds light on the potential of these molecules but also offers hope for effective treatments for millions affected by these conditions.

Dr. Shahnawaz Ali Bhat is an Assistant Professor in the Department of Zoology at Aligarh Muslim University (AMU), Aligarh, India. Currently his research program focuses on deciphering the molecular and cellular processes/pathways involved in the pathogenesis of neurodegenerative diseases and metabolic disorders. Further, he is also interested in neuropharmacological and neurotoxicological studies to screen or identify various bioactive molecules for effective prevention of neurodegenerative diseases and hypertension-induced neurodegeneration.