Solid-Phase Synthesis: A Practical Guide, 1st Edition (Hardback) book cover

Solid-Phase Synthesis

A Practical Guide, 1st Edition

Edited by Fernando Albericio

CRC Press

848 pages

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Hardback: 9780824703592
pub: 2000-04-28
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Description

This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Reviews

"Prepublication praise for Solid-Phase Synthesis. . . Both Fernando Albericio and Steven Kates, as well as most of the authors of individual chapters, are well known to members of the synthetic peptide community and the information they provide can be considered authoritative and reliable. . .. While writing this piece I had occasion to look in the manuscript for answers to two specific questions and readily found both. I intend to keep a copy of this book on my desk for ready reference and I can recommend that every peptide chemist and many classical organic chemists do the same."

---from the Foreword by R. B. Merrifield, The Rockefeller University, New York, N.Y.

Table of Contents

The solid support strategy in solid-phase synthesis; amino acids -alpha-amino protecting groups; side-chain protecting groups; solid supports for the synthesis of peptides and small molecules; coupling methods - solid-phase formation of amide and ester bonds; homodetic cyclic peptides; disulfide formation in synthetic peptides and proteins -the state of the art; solid-phase convergent approaches to the synthesis of native peptides and proteins; preparation of glyco-, phospho-, and sulfopeptides; oligonucleotide synthesis; synthesis of oligonucleotide-peptide conjugates and nucleopeptides; the chemistry of peptide nucleic acids; solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics; instrumentation; the purification of synthetic peptides; analysis of synthetic peptides; the chromatographic analysis of combinational arrays - parallel HPLC and HPLC-MS.

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI013040
SCIENCE / Chemistry / Organic