1st Edition

Biology and Clinical Implications

Edited By

C. Yan Cheng

ISBN 9781498764117
Published November 12, 2018 by CRC Press
292 Pages 28 Color & 8 B/W Illustrations

USD $200.00

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Book Description

Senior investigators internationally have here collaborated to produce an international reference work. Each contributor provides critical and thought provoking concepts and ideas based on the latest developments in their field. The result is a must read and timely reference work for investigators who are interested in how spermatogenesis is currently understood and which are the most promising avenues for future research; an Introduction sets the context for the chapter and points out the relevance of the research for basic research scientists and clinicians.

Table of Contents



1. Golgi apparatus regulation of differentiation: A case study for male germ cells of the rat testis

Louis Hermo, Regiana L. Oliveira, Charles E. Smith, Catherine E. Au, and John J. M. Bergeron

2. Androgen regulation of spermatogenesis

William H. Walker

3. Testicular immunoregulation: The role of Tyro3, Axl, and Mer receptor tyrosine kinases and pattern recognition receptors

Fei Wang, Qian Jiang, and Daishu Han

4. Inflammation and Spermatogenesis

Maria Susana Theas, Patricia Verónica Jacobo, Cecilia Valeria Pérez, Vanesa Anabella Guazzone, and Livia Lustig

5. Junctional adhesion molecule (JAM) family: Recent findings and their role and regulation in spermatogenesis

Kun Huang and Wing-Yee Lui

6. Sertoli cell immune regulation within the testis

Gurvinder Kaur, Kandis Wright, Robin Hannah Greer, Karl Mueller, Allan Haynes, and Jannette M. Dufour

7. The mitotic phase of spermatogenesis: Recent advances and perspectives

Kin Lam Fok and Hsiao Chang Chan

8. Genetics of mammalian meiosis

Fang Yang and P. Jeremy Wang

9. Roles of membrane and nuclear estrogen receptors in spermatogenesis

Paul S. Cooke, Manjunatha K. Nanjappa, Sergei G. Tevosian, and Rex A. Hess

10. Regulation of fertility and infertility in humans

Nahid Punjani, Ryan Flannigan, and Peter N. Schlegel

11. Male infertility: Evaluation and treatment

Ryan Flannigan and Marc Goldstein

12. Effects of chemical pollutants on spermatogenesis and implications in male infertility

Chris KC Wong

13. Advances in our understanding of human spermatogenesis

Qing Wen, Elizabeth I. Tang, Tito Jesus, Bruno Silvestrini, and C. Yan Cheng

14. A look into the testis as a reservoir for HIV and ZIKV—A reproductive biologist’s perspective

Elizabeth I. Tang, Christopher L. Robinson, Chi Nok Chong, Shuibing Chen, and C. Yan Cheng

15. Cytoskeletons (F-actin) and spermatogenesis

Liza O’Donnell and Peter G. Stanton

16. Roles of mTOR signaling in spermatogenesis

Lan Ye and Ke Zheng

17. Does planar cell polarity matter during spermatogenesis?

Linxi Li, Haiqi Chen, Qingquan Lian, Ren-Shan Ge, and C. Yan Cheng

18. Computational characterization and integrative analysis of proteins involved in Spermatogenesis

Pranitha Jenardhanan, Manivel Panneerselvam, and Premendu P. Mathur

19. Effects of chemical exposures on testis cell-cell interactions and endocrine function

Rachel C. Knight, Jennifer R. Panizzi, and Benson T. Akingbemi

20. Environmental toxicants on Leydig cell function

Leping Ye, Xiaoheng Li, Xiaomin Chen, Qingquan Lian, and Ren-Shan Ge



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C. Yan Cheng Ph.D. is a senior scientist at the Population Council’s Center for Biomedical Research, New York, affiliated with the Council's Reproductive Health program, where his research focuses on developing new male contraceptive methods through a better understanding of male fertility and infertility, and on the biology of the blood-testis barrier and the mechanism by which environmental toxicants induce testicular injury. He serves as an ad-hoc reviewer of grant proposals submitted to the National Institutes of Health’s Cellular, Molecular and Integrative Reproduction Study Section and the Endocrinology, Metabolism, Nutrition and Reproductive Sciences Study Section. He holds a Ph.D. in biochemistry and cell biology from the University of Newcastle, New South Wales, Australia, after an undergraduate degree from the Chinese University of Hong Kong. His research has been supported by the National Institute of Child Health and Human Development, National Institutes of Health, for the last three decades. He has published more than 400 peer-reviewed papers. He was awarded the Richard E. Weizman Memorial Award from the Endocrine Society in 1988 and received the Best Scientific Paper Award from the American Society of Andrology in 1997. He also served as the Editor-in-Chief of the peer-review journal Spermatogenesis from 2011 through 2016.


"This is a remarkable addition to the field of spermatogenesis, furthering our
understanding of meiosis and new developments in the conversion of early
spermatocytes to haploid spermatids, a process clinically relevant to the
treatment of nonobstructive azoospermia. It uniquely addresses the contemporary
challenges of environmental spermatotoxins."

Irvin H Hirsch, MD (Thomas Jefferson University)