1st Edition

Spermatogenesis Biology and Clinical Implications

Edited By C. Yan Cheng Copyright 2019
    292 Pages 28 Color & 8 B/W Illustrations
    by CRC Press

    292 Pages 28 Color & 8 B/W Illustrations
    by CRC Press

    Senior investigators internationally have here collaborated to produce an international reference work. Each contributor provides critical and thought provoking concepts and ideas based on the latest developments in their field. The result is a must read and timely reference work for investigators who are interested in how spermatogenesis is currently understood and which are the most promising avenues for future research; an Introduction sets the context for the chapter and points out the relevance of the research for basic research scientists and clinicians.



    1. Golgi apparatus regulation of differentiation: A case study for male germ cells of the rat testis

    Louis Hermo, Regiana L. Oliveira, Charles E. Smith, Catherine E. Au, and John J. M. Bergeron

    2. Androgen regulation of spermatogenesis

    William H. Walker

    3. Testicular immunoregulation: The role of Tyro3, Axl, and Mer receptor tyrosine kinases and pattern recognition receptors

    Fei Wang, Qian Jiang, and Daishu Han

    4. Inflammation and Spermatogenesis

    Maria Susana Theas, Patricia Verónica Jacobo, Cecilia Valeria Pérez, Vanesa Anabella Guazzone, and Livia Lustig

    5. Junctional adhesion molecule (JAM) family: Recent findings and their role and regulation in spermatogenesis

    Kun Huang and Wing-Yee Lui

    6. Sertoli cell immune regulation within the testis

    Gurvinder Kaur, Kandis Wright, Robin Hannah Greer, Karl Mueller, Allan Haynes, and Jannette M. Dufour

    7. The mitotic phase of spermatogenesis: Recent advances and perspectives

    Kin Lam Fok and Hsiao Chang Chan

    8. Genetics of mammalian meiosis

    Fang Yang and P. Jeremy Wang

    9. Roles of membrane and nuclear estrogen receptors in spermatogenesis

    Paul S. Cooke, Manjunatha K. Nanjappa, Sergei G. Tevosian, and Rex A. Hess

    10. Regulation of fertility and infertility in humans

    Nahid Punjani, Ryan Flannigan, and Peter N. Schlegel

    11. Male infertility: Evaluation and treatment

    Ryan Flannigan and Marc Goldstein

    12. Effects of chemical pollutants on spermatogenesis and implications in male infertility

    Chris KC Wong

    13. Advances in our understanding of human spermatogenesis

    Qing Wen, Elizabeth I. Tang, Tito Jesus, Bruno Silvestrini, and C. Yan Cheng

    14. A look into the testis as a reservoir for HIV and ZIKV—A reproductive biologist’s perspective

    Elizabeth I. Tang, Christopher L. Robinson, Chi Nok Chong, Shuibing Chen, and C. Yan Cheng

    15. Cytoskeletons (F-actin) and spermatogenesis

    Liza O’Donnell and Peter G. Stanton

    16. Roles of mTOR signaling in spermatogenesis

    Lan Ye and Ke Zheng

    17. Does planar cell polarity matter during spermatogenesis?

    Linxi Li, Haiqi Chen, Qingquan Lian, Ren-Shan Ge, and C. Yan Cheng

    18. Computational characterization and integrative analysis of proteins involved in Spermatogenesis

    Pranitha Jenardhanan, Manivel Panneerselvam, and Premendu P. Mathur

    19. Effects of chemical exposures on testis cell-cell interactions and endocrine function

    Rachel C. Knight, Jennifer R. Panizzi, and Benson T. Akingbemi

    20. Environmental toxicants on Leydig cell function

    Leping Ye, Xiaoheng Li, Xiaomin Chen, Qingquan Lian, and Ren-Shan Ge




    C. Yan Cheng Ph.D. is a senior scientist at the Population Council’s Center for Biomedical Research, New York, affiliated with the Council's Reproductive Health program, where his research focuses on developing new male contraceptive methods through a better understanding of male fertility and infertility, and on the biology of the blood-testis barrier and the mechanism by which environmental toxicants induce testicular injury. He serves as an ad-hoc reviewer of grant proposals submitted to the National Institutes of Health’s Cellular, Molecular and Integrative Reproduction Study Section and the Endocrinology, Metabolism, Nutrition and Reproductive Sciences Study Section. He holds a Ph.D. in biochemistry and cell biology from the University of Newcastle, New South Wales, Australia, after an undergraduate degree from the Chinese University of Hong Kong. His research has been supported by the National Institute of Child Health and Human Development, National Institutes of Health, for the last three decades. He has published more than 400 peer-reviewed papers. He was awarded the Richard E. Weizman Memorial Award from the Endocrine Society in 1988 and received the Best Scientific Paper Award from the American Society of Andrology in 1997. He also served as the Editor-in-Chief of the peer-review journal Spermatogenesis from 2011 through 2016.

    "This is a remarkable addition to the field of spermatogenesis, furthering our
    understanding of meiosis and new developments in the conversion of early
    spermatocytes to haploid spermatids, a process clinically relevant to the
    treatment of nonobstructive azoospermia. It uniquely addresses the contemporary
    challenges of environmental spermatotoxins."

    Irvin H Hirsch, MD (Thomas Jefferson University)