Examining the strengths and limitations of various standards of accuracy in clinical laboratory analyses, this detailed reference presents an in-depth study of important theoretical and empirical issues concerning the description, collection, and application of reference values in laboratory medicine.
…The authors…have bridged the gap between the pedantic recitation of statistical dogma and practical application of those tools to the considerable task of establishing appropriate reference values for the analytes we measure…the most significant contribution they make is in relating this application to the real issue in laboratory medicine today: how we can contribute to lowering episode-of-care cost.
"…thorough…authoritative…an excellent addition to departmental and institutional libraries.
"-Doody's Health Sciences Book Review Journal
"…This book is the first book I have seen which covers so much of the area of variation in measurement, and explains it very clearly…essential.
"-International Society for Clinical Biostatistics News
Some History of Reference Values
Calculating Reference Limits
Sample Sizes and Subgroups
Multivariate Reference Regions and Indices
Time-Dependent Reference Values
Comparison of Within-Subject and Among-Subject Variances
Predictive Values for Monitoring Healthy Subjects and Patients
Analytical Goals for Reference Values
Analytical Goals In Therapeutic Drug Monitoring
Reference Values in the Future