Statistical Genomics: Linkage, Mapping, and QTL Analysis, 1st Edition (Hardback) book cover

Statistical Genomics

Linkage, Mapping, and QTL Analysis, 1st Edition

By Ben Hui Liu

CRC Press

648 pages

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Hardback: 9780849331664
pub: 1997-12-29
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Description

Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.

Reviews

"The book deals with one of the most active areas of genomic science… It is a very comprehensive treatment of the subject from a practical and theoretical perspective. This book is significantly ahead of what is currently published."

Ronald Sederoff

North Carolina State University

"First, this book is extremely timely as genomics and gene mapping is an area undergoing exponential growth. Second, the coverage is indeed excellent. Third, Dr. Liu is extremely well qualified to write this book… he knows both the underlying theory as well as problems in applying it in real settings."

Bruce Walsh

University of Arizona

Table of Contents

Introduction

Forward

Introducing Genomics

Statistical Genomics

Related Books

Biology in Genomics

Introduction

Mendelian Genetics and Cytogenetics

Population Genetics

Quantitative Genetics

Molecular Genetics

Exercises

Introduction to Genomics

Genome

Genomics

Genetic Markers

Exercises

Statistics in Genomics

Introduction

Distribution Likelihood

Hypothesis Test

Estimation

Sample Size Determination

Summary

Exercises

Single-Locus Models

Introduction

Expected Segregation Ratio

Marker Screening

Natural Population

Exercises

Two-Locus Models I: Controlled Cross

Introduction

Linkage Detection

Recombination Frequency Estimation

Statistical Properties

Sample Size Consideration

Dominant Markers in F2 Progeny

Violation of Assumptions

Summary

Exercises

Two-Locus Model II: Natural Population

Introduction

Linkage Phase Problem

Mixture of Self and Random Mating

Exercises

Two-Locus Model III: Using Disequilibrium

Introduction

Linkage Disequilibrium

Transmission Disequilibrium Test

Other Disequilibrium Based Analysis

Estimation of Recombination Frequency

Exercises

Linkage Grouping and Locus Ordering

Introduction

Linkage Grouping

Three-Locus Ordering

Multiple-Locus Ordering

Probability of Estimated Locus Orders

Exercise

Multi-Locus Model

Introduction

Three-Locus Model

Map Function

Multi-Locus Map Distance

Marker Coverage and Map Density

Exercises

Linkage Map Merging

Introduction

Factors Related to Linkage Map Merging

Hypothesis on Gene Orders

Linkage Map Pooling

Exercises

QTL Mapping I: Introduction

History

Quantitative Genetics Models

Example Data

Exercise

QTL Mapping II: Single-Marker Analysis

Rationale

Single-Marker Analysis in Backcross Progeny

Single Marker Analysis Using F2 Progeny

Summary

Exercises

QTL Mapping III: Interval Mapping

Introduction

Interval Mapping Using Backcross Progeny

Interval Mapping Using F2 Progeny

Composite Interval Mapping

Summary

Exercises

QTL Mapping IV: Natural Population

Introduction

Open-Pollinated Populations

Sib-Pair Method

Exercises

QTL Mapping V: Power

Introduction

Single QTL Detection Power

Multiple QTL

Exercises

QTL Mapping VI: Future Considerations

Problems with QTL Mapping

QTL Resolution

Mapping Strategies

What are QTL

Future QTL Mapping

Exercises

Computer Tools

Computer Tools for Genomic Data Analysis

Future Considerations

PGRI (Plant Genome Research Initiative

Resampling and Simulation in Genomics

Introduction

Resampling

Computer Simulation

Mapping Population Simulation

Exercises

Bibliography

Author Index

Subject Index

Subject Categories

BISAC Subject Codes/Headings:
MAT029000
MATHEMATICS / Probability & Statistics / General
SCI008000
SCIENCE / Life Sciences / Biology / General
SCI010000
SCIENCE / Biotechnology