1st Edition

Statistical Methods in Psychiatry and Related Fields Longitudinal, Clustered, and Other Repeated Measures Data

By Ralitza Gueorguieva Copyright 2018
370 Pages
by Chapman & Hall

370 Pages 70 B/W Illustrations
by Chapman & Hall

370 Pages 70 B/W Illustrations
by Chapman & Hall

Data collected in psychiatry and related fields are complex because outcomes are rarely directly observed, there are multiple correlated repeated measures within individuals, there is natural heterogeneity in treatment responses and in other characteristics in the populations. Simple statistical methods do not work well with such data. More advanced statistical methods capture the data... Read more

Introduction



Traditional Methods for Analysis of Longitudinal and Clustered Data



Linear Mixed Models for Longitudinal and Clustered Data





Linear Models for Non-normal Outcomes



Nonparametric Methods for the Analysis of Repeatedly Measured Data





Post-hoc Analysis and Adjustments for Multiple Comparisons





Handling of Missing Data and Dropout in Longitudinal Studies





Controlling for Covariates in Studies with Repeated Measures





Assessment of Moderator and Mediator Effects





Mixture Models for Trajectory Analyses



Study Design and Sample Size Calculations



Summary and Further Readings



 



 

Biography

Ralitza Gueorguieva is a Senior Research Scientist at the Department of Biostatistics, Yale School of Public Health. She has more than 20 years experience in statistical methodology development and collaborations with psychiatrists and other researchers, and is the author of over 130 peer-reviewed publications.

"This is a comprehensive text describing a wide-range of statistical techniques, from basic to advanced, applicable to data generated from the field of Mental Health research. The field of Psychiatry is one of the very core subjects of Mental Health, along with Clinical Psychology and Psychiatric SocialWork. Hence, it is in fact an amalgamation of many cross linking fields of the social sciences. Therefore, coming out with a book that addresses various dimensions of science is a remarkable achievement. … [T]he book has three unique selling points – addressing the issues of the different natures of data in psychiatry, post hoc analyses and adjustments for multiple comparisons, and study design and sample size determination. … I very strongly advocate that researchers/academics have this book with them or in their library."
—Chandra Bhushan Tripathi, in ISCB News, December 2018

"This book will reach a wide audience since it gives a non-technical and comprehensible introduction for non-experts to a complicated topic, with a series of worked-through examples, while at the same time it provides the applied statistician with thorough guidance to the analysis of longitudinal data, in the traditional normal distribution setting as well as for non-normal distributions (binary, Poisson etc.). It also contains insightful discussions on more advanced topics, with good references for further reading. The book stands out in the discussion on multiple testing, with good advice in a jungle of possibilities and in the handling of missing values (a comprehensible explanation of the problems and pitfalls, together with a sober guidance to avoiding such pitfalls in various circumstances). Also, the section on causality is probably the best I ever came across.The guidance and summary sections at the end of each chapter will serve as a reminder on the important hints for this particular topic.
An extremely nice addition to the book is the accompanying ho