Stem Cell Labeling for Delivery and Tracking Using Noninvasive Imaging provides a comprehensive overview of cell therapy imaging, ranging from the basic biology of cell therapeutic choices to the preclinical and clinical applications of cell therapy. It emphasizes the use of medical imaging for therapeutic delivery/targeting, cell tracking, and determining therapeutic efficacy.
The book first presents background information and insight on the major classes of stem and progenitor cells. It then describes the main imaging modalities and state-of-the-art techniques that are currently employed for stem cell tracking. In the final chapters, leading scholars offer clinical perspectives on existing and potential uses of stem cells as well as the impact of image-guided delivery and tracking in major organ systems.
Through clear descriptions and color images, this volume illustrates how noninvasive imaging is used to track stem cells as they repair damaged tissue in the body. With contributions from some of the most prominent preclinical and clinical researchers in the field, the book helps readers to understand the evolving concepts of stem cell labeling and tracking as the field continues to move forward.
Introduction: Stem Cell Types Overview and Rationale for Labeling for Imaging. Human Embryonic Stem Cells. Mesenchymal Stem Cells from Bone Marrow. Hematopoietic Stem Cells. Adipose-Derived Adult Stem Cells. Umbilical Cord Stem Cells. Induced Pluripotent Stem Cells. Radionuclide Approaches to Imaging Stem Cells and Their Biological Effects on the Myocardium. Fluorescence Imaging of Stem Cells In Vivo: Evolving Technologies and Applications. Ultrasound Imaging Basics. MRI Basics and Principles for Cellular Imaging. X-Ray Imaging Basics. Radionuclide Cell-Labeling Methods. Principles of Bioluminescence Imaging and Its Application In Vivo. Quantum Dot Labeling Methods. Magnetic Resonance Imaging Cell-Labeling Methods. Ultrasound Cell-Labeling Methods. X-Ray-Guided Delivery and Tracking of Cells. Multimodality/Fusion Imaging toward Imaging of Structure and Function. Other Non-Stem Cell Therapies for Cellular Tracking—Inflammatory Cell Tracking. Bioluminescence, MRI, and PET Imaging Modalities of Stem Cell-Based Therapy for Neurological Disorders. Clinical Application of Noninvasive Molecular Imaging in Cancer Cell Therapy: The First Reporter Gene-Based Imaging Clinical Trial. Clinical Cardiology Stem Cell Applications. Musculoskeletal Clinical Applications of Stem Cells. Regulatory Hurdles to Translation. Index.