1st Edition

Supercritical Fluid Technology for Drug Product Development

Edited By Peter York, Uday B. Kompella, Boris Y. Shekunov Copyright 2004

    Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical products-from drug powders for respiratory delivery to drug delivery systems for controlled release.

    Chemistry and Materials Design for Pharmaceutical Applications. Phase Equilibrium in Solid-Liquid-Supercritical Fluid Systems. Mechanisms of Particle Formation Using Supercritical Fluids. Methods of Particle Production. Colloid and Interface Science for CO2-based Pharmaceutical Processes. Production of Powders for Respiratory Drug Delivery. Control of Physical Form of Drug Substances. Supercritical Fluid Impregnation of Polymers for Drug Delivery. Formulation of Controlled Drug Release Systems. Processing of Biological Materials. Asymmetric Catalysis in Supercritical Fluids. Analytical and Semi-Preparative Supercritical Fluid Chromatography in Drug Discovery. Drug Extraction Development and Potential of Critical Fluid Technology in the Neutraceutical Industry. Scale-Up Issues for Supercritical Fluid Processing in Compliance with GMP


    Peter York, Uday B. Kompella, Boris Y. Shekunov

    "…fill[s] a gap and provides useful knowledge, and is highly recommended to anyone whi is engaged in the increasing development of supercritical fluid technology for pharmaceutical applications."
    -Drug Delivery Systems and Sciences

    "…thie collection grings together the fundamentals, process engineering, and pharmaceutical applications of supercritical fluid technologies."
    -SciTech Book News