The chemical properties of superoxide ion, its biological role, and the role of other oxygen radicals which arise as a result of its transformations are contained in this text. In Volume I the principal reactions of superoxide ion, including protonation reactions with proton donors, nucleophilic reactions with esters, alkyl halides and other compounds, electron transfer reactions with quinones and metal complexes, are described. Basic quantitative data including rate constants and yields for the reactions of superoxide ion of all types are given in tables. This volume contains the mechanisms of the generation of oxygen radicals in cells and the interaction of superoxide ion with cell components. The role of superoxide ion in lipid peroxidation and destruction of proteins and nucleic acids is explained, as well as oxygen radicals in the mechanisms of toxic and therapeutic action of drugs, especially anticancer antibiotics. In addition, the action of superoxide ion and other oxygen radicals on plants, micro-, and macroorganisms is discussed, along with the role of oxygen radicals in normal metabolic and pathological processes.
Table of Contents
VOLUME II: Preface. Who is the Villain? Classification and Reactivities of Oxygen Species in Biological Systems. Nonenzymatic and Enzymatic Production of Oxygen Radicals in Biological Systems. Production of Oxygen Radicals by Xenobiotics. Production of Oxygen Radicals by Cells. The Interaction of Oxygen Radicals with Natural and Biologically Active Compounds, Cellular Components and Cells. Appendices. Index.
Igor B. Afanas'ev (All-Union Vitamin Research Institute, Moscow, Russia) (Author)