Surgical Adhesives & Sealants: urrent Technology and Applications, 1st Edition (Paperback) book cover

Surgical Adhesives & Sealants

urrent Technology and Applications, 1st Edition

By David H. Sierra, Renato Saltz

CRC Press

247 pages

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Paperback: 9781566763271
pub: 1998-03-31
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Description

From the Preface

Surgical tissue adhesives are an ancient idea, going back to the beginnings of recorded history. The concept of adhering, rather than suturing, packing, or stapling planes of tissue is attractive, in that it is fast-acting and assures complete closure. Numerous technologies have been tried; some with limited success, others outright failures. In short, the perfect adhesive does not exist. Limitations occur in a number of areas: strength, toxicity, degradation, and safety. It is also important to keep in mind that "one size fits all" does not apply to adhesives in surgical applications any more than it does in day-to-day application. As one would not use paper glue to seal a bathtub, one would presumably not apply an adhesive onto tendons, which is suitable for sealing corneas. The properties required of an adhesive for each indication are quite different.

Over the last twenty-five years, advances have been made in a wide range of technologies targeting some embodiment of a practical and safe adhesive. Foremost and successful among these are cyanoacrylates, marine adhesive proteins, and fibrin-based sealants. Another promising adhesive technology is laser solders, a mixture of polypeptides and proteoglycans, which integrates with the repair site when laser energy is applied.

In light of these advances in the field, the Symposium for Surgical Tissue Adhesives was organized and held at the Atlanta Hyatt from October 8-10, 1993. The goal was to bring together these far-flung technologies in a comprehensive and cohesive manner. Presentations by investigators from around the world described the history of adhesives in medicine, current technologies, laboratory characterizations, and application developments, as well as regulatory aspects and clinical applications. We felt that as many viewpoints as possible, however conflicting, were important to present in order to give the most complete picture of the state of the art of surgical adhesives.

Table of Contents

ADHESIVE TECHNOLOGIES

History of Tissue Adhesives

Commercial Pooled-Source Fibrin Sealant

Mussel Adhesive Protein

Fibrin-Collagen Composite Tissue Adhesive

Soldering Is a Superior Alternative to Fibrin Sealant

LABORATORY EVALUATION

Kinetic and Mechanical Parameters of Fibrin Glue

Surgical Tissue Adhesives: Host Tissue Response, Adhesive Strength and Clinical Performance

Biological and Rheological Properties of a Virally Inactivated Fibrin Glue (Biocolr): Comparison to an Autologous Fibrin Glue

Assessment of Restored Tissue Elasticity in Prolonged in vivo Animal

Veterinary Hemaseelr: Ex vivo and in vivo Studies on Bovine Fibrin Sealant

LABORATORY APPLICATIONS

Wound Healing Applications of Fibrin Sealants

Fibrin Sealant: A Versatile Delivery Vehicle for Drugs and Biologics

Sustained Release of Antibiotics from Fibrin Sealant

Bone Induction by Demineralized Bone Powder and Partially Purified Osteogenin Using a Fibrin-Sealant Carrier

Fibrin Sealant as a Delivery Vehicle for Sustained and Controlled Release of Chemotherapy Agents

Experimental and Clinical Considerations: Craniofacial Surgery and Bone Metabolism

CLINICAL APPLICATIONS AND INVESTIGATIONS

Fibrin Sealant and the U.S. Food and Drug Administration Review

Utilization of Fibrin Glue in Craniofacial and Facial Plastic Surgery

Tissue Adhesives in Plastic and Reconstructive Surgery

Clinical Applications of Tissue Adhesives in Aesthetic and Reconstructive Surgery

Surgical Adhesives in Otolaryngology

A Review of Nonsuture Peripheral Nerve Repair

Clinical Use of Fibrin-Based Composite Tissue Adhesive in Otology and Neurotology

Clinical Applications of Fibrin Sealant in Thoracic and Cardiovascular Surgery

Subject Categories

BISAC Subject Codes/Headings:
TEC021000
TECHNOLOGY & ENGINEERING / Material Science