1st Edition

Synaptic Plasticity in Neurodegenerative Disorders

    288 Pages 27 Color Illustrations
    by CRC Press

    This book explores the pivotal role of synaptic plasticity in the pathogenesis, progression, and potential treatment of neurodegenerative disorders. The initial chapter provides an in-depth understanding of the complexity and impact of neurodegenerative conditions. It discusses the association of mitochondrial dysfunction, epigenetic influences, and neuroinflammation with synaptic plasticity in neurodegenerative diseases. The following chapters review the dynamic changes that occur at the cellular and synaptic levels in Parkinson's Disease, Alzheimer's Disease, and Huntington's Disease, paving the way for innovative therapeutic strategies. Furthermore, the book presents various computational tools and methodologies essential for enhancing our understanding of synaptic plasticity. It examines the transformative role of artificial intelligence tools in addressing synaptic impairment across various neurodegenerative diseases. Towards the end, the book explores the role of synaptic impairment and computational neuroscience in understanding and potentially treating conditions such as multiple sclerosis and amyotrophic lateral sclerosis. With its multifaceted approach, this book serves as a useful resource for researchers, clinicians, and students in the fields of neuroscience, computational biology, and neurology. 

    Chapter 1: General Introduction to Different Neurodegenerative Diseases

    Prabhakar Singh, Saqib Hassan, Kunal Biswas, V Ramesh Kumar

    Chapter 2: Chemical-Induced Parkinson’s Disease Model and Associated Therapeutic Strategies

    Sandhya Yadav, Manish Kumar Tripathi

    Chapter 3: Recent Advancement in the Treatment of Parkinson’s Disease Cellular Models

    Mansi Gandhi, Devhuti Palan

    Chapter 4: Relevance of Genetic Model and Linked Therapeutics in Parkinson’s Disease

    Kakarla Ramakrishna, Samuel Junior Osei Asokwah, Grace Mwihaki Njuguna, Hayiru Mohammed, Naresh Dumala, Matte Kasi Viswanadh, Guntupalli Chakaravarthi, Buchi N Nalluri, Vinjavarapu Lakshmi Anusha

    Chapter 5: Importance of Newer 3D Organoids Model Based Therapeutic Approach in Parkinson’s Disease

    Kakarla Ramakrishna, Hayiru Mohammed, Grace Mwihaki Njuguna, Samuel Junior Osei Asokwah, Vineeta Singh, Naresh Dumala, Matte Kasi Viswanadh, Vinjavarapu Lakshmi Anusha, Guntupalli Chakaravarthi, Buchi N Nalluri

    Chapter 6: Chemical Induced Alzheimer’s Disease Model and Their Therapeutic Significance Along with Limitations

    Ashutosh Gupta, Aakansha Pathak, Neeraj Kumar

    Chapter 7: Advancement in the Genetic Model of Alzheimer’s Disease

    Priti Kanik, Rashi Kumar, Ritu Varshney

    Chapter 8: Organoids and Alzheimer's Disease

    Payal Singh, Shashank Shekhar Mishra, Pradeep Kumar

    Chapter 9: Importance of Genetic Model in Huntington’s Disease

    Mehak Bajaj, Mansi Gandhi, Devhuti Palan

    Chapter 10: Natural Source of Drugs for Neurodegenerative Diseases

    Chandrabhan Prajapati, Sachchida Nand Rai, Pooja Chaurasia, Shashank Shekhar Mishra, Anurag Kumar Singh, Santosh Kumar Singh

    Chapter 11: Limitations of Modelling in Different Neurodegenerative Diseases

    Chandra Prakash, Shyam Sunder Rabidas, Deepak Sharma

    Chapter 12: Significance of 3D Organoid Model in Neurodegenerative Diseases

    Ishita Bhardwaj, Atifa Haseeb Ansari, Raghvendra Pratap, Sippy Singh, Durgesh Singh

    Chapter 13: Recent Advancement in Therapeutics of Rare Neurological Disorders

    Faiza Parvez, Atifa Haseeb Ansari, Durgesh Singh, Sippy Singh

    Chapter 14: Bio-Informatics Based Modeling in Different Neurodegenerative Diseases and Associated Therapeutic Strategies

    Atifa Haseeb Ansari, Swayam Prabha Rai, Shivani Pathak, Sippy Singh

    Chapter 15: Holistic Management of Diverse Neurodegenerative Diseases in Different Translational Models

    Prabhash Kumar Pandey, Ashutosh Shrivastava, Anshuman Srivastava, Mohit, Amita Jain, Vimala Venkatesh, Soni Tiwari, Shiva Shukla, Farrukh Jamal

    Chapter 16: Gene Therapy, OMICS Approaches, and Translational Neurodegenerative Models: Recent Advancements and Future Perspectives

    Aakriti Sharma, Shashank Shekhar Mishra, Sandeep Singh

    Chapter 17: Implication and Importance of Stem Cell Therapy in a Translational Model of Neurodegenerative Diseases

    Shashank Kumar Ojha


    Dr. Sangeeta Singh is an Assistant Professor in the Department of Applied Science at the Indian Institute of Informational Technology, Allahabad (IIIT A), Prayagraj, Uttar Pradesh (UP), India. Prior to joining IIIT Allahabad, she worked at the ICAR Indian Veterinary Research Institute in Izzatnagar, Bareilly (UP), India. She completed her Ph.D. in 2010. Dr. Singh's research interests include neurodegenerative disorders and regenerative medicine to promote neuronal repair and regeneration. She has received various research grants from the Science and Engineering Research Board (SERB) and the Department of Science and Technology, India. Dr. Singh has published more than 50 research articles in high-impact journals, in addition to contributing book chapters and conference proceedings. Furthermore, Dr. Singh serves as a reviewer for various reputable journals and is also a Life Member of various esteemed societies, such as the Indian Academy of Neurosciences (India), the Association of Microbiologists of India, and the Society for Biomaterials and Artificial Organs India. Dr. Santosh Kumar Singh is a Senior Scientist at the Centre of Experimental Medicine and Surgery (CEMS), Faculty of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. He earned his Ph.D. from the Botany Department (Institute of Science), BHU, in 1998. In 2003, he served as a Visiting Scientist at the Department of Photosynthesis, Institute of Physical Biology, University of South Bohemia, Czech Republic. Dr. Singh has published more than 75 research articles in high-impact and reputable journals. His research primarily focuses on Drug Discovery and Development, Microbial Biotechnology, and Nanobiotechnology. Dr. Singh is a member of the Mycological Society of India, the Society of Biological Chemists, India, and the Society for Ethnopharmacology, Kolkata, India (SFE INDIA). He has served as a resource person in the Karyashala Training Course under the Accelerate Vigyan Scheme, SERB, and DST. Notably, he was awarded the "National Award for Outstanding Efforts in Science and Technology Communication through Innovative and Traditional Methods (2021)" by the Department of Science and Technology, Ministry of Science and Technology, Government of India. In 2020–2021, he also received the Order of Academic Excellence in Publication from the Institute of Medical Sciences, Banaras Hindu University, Varanasi. Dr. Sachchida Nand Rai is a Research Associate (ICMR RA) at the Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University (BHU), Varanasi. Dr. Rai completed his Ph.D. from the Biochemistry Department (Institute of Science), BHU. Before joining BHU as a Research Associate, he held a post-doctoral fellowship at the Centre of Biotechnology, University of Allahabad, Prayagraj, India. Additionally, he serves as an editorial board member for many renowned journals and has published several research articles in journals of high repute.