1st Edition

Syncope From Etiopathogenesis to New Therapeutic Options

Edited By Tolga Aksu, Carlos A. Morillo Copyright 2025
    264 Pages 19 Color & 20 B/W Illustrations
    by CRC Press

    264 Pages 19 Color & 20 B/W Illustrations
    by CRC Press

    Syncope is a common condition related to transient loss of consciousness due to global cerebral hypoperfusion and caused by a variety of aetiologies. Although it is self-limited, and usually benign, syncope can be the harbinger of life-threatening heart rhythm problems due to cardiac conditions. A multidisciplinary approach is practical for its evaluation and treatment, requiring the expertise of cardiologists, neurologists, emergency medicine specialists, and other clinicians. This book provides a detailed review of etiopathogenesis and a state-of the art update on therapeutic options offering recommendations based on the guidelines and experience of experts while discussing procedures and tests with their indications, methodology, interpretation, and limitations.

    Key Features: 1. Discusses new diagnostic tools, and therapeutic modalities, with supportive videos in each chapter. 2. Provides up-to-date recommendations regarding the indications for and appropriate interpretation of non-invasive and invasive cardiac testing, for cardiologists and internists. 3. Places particular emphasis on diagnosing and treating reflex and arrhythmic syncope.

    Chapter 1: Syncope: Definition, Terminology and Classification


    John A. Paydar, Liane A. Arcinas, Carlos A. Morillo, Robert S Sheldon, and Satish R Raj


    Chapter 2. Epidemiology and Economics of Syncope

    Dana Shiffer and Raffaello Furlan

    Chapter 3. Etiopathogenesis of Syncope

    Lina E. Lombo, Juan Camilo Guzmán

    Chapter 4. Initial Evaluation and Risk Stratification in Syncope

    Robert Sheldon, Liane Arcinas, Frederik de Lange, and Roopinder Sandhu

    Chapter 5. Diagnostic Tests in Syncope

    Chapter 5A. Tilt-table testing, Autonomic Tests and Electrophysiological Study

    Wayne O Adkisson, and David G Benditt

    Chapter 5B. ECG, Prolonged Ambulatory Monitoring, and Exercise Stress Testing

    Matthew T. Bennett, and  Andrew D Krahn

    Chapter 6. Reflex Syncope

    6A. Vasovagal Syncope

    William H. Parker, Mark W. Chapleau, and Brian Olshansky

    6B. Other Causes of Reflex syncope

    Piotr Kulakowski

    Chapter 7. Adenosine Sensitive Syncope: Diagnosis & Management

    Régis Guieu, Michele Brignole, and Jean Claude Deharo

    Chapter 8. Disorders of Orthostatic Intolerance: Orthostatic Hypotension and Postural Orthostatic Tachycardia Syndrome

    Jacquie R. Baker, and Satish R. Raj

    Chapter 9. Cardiac Syncope

    Angel Moya-Mitjans and Jaume Francisco-Pascual

    Chapter 10. Syncope in children

    Khalil Kanjwal, Wasim Rashid, and Blair P. Grubb

    Chapter 11. Pseudosyncope and ictal syncope: Diagnosis & Management


    Leonardo Calò, Marco Rebecchi, Pietro Desimone, Doménico Giamundo, Ermenegildo De Ruvo, and Antonella Sette


    Chapter 12. Other neurological conditions (Sleep disorders, autonomic failure, and structural brain lesions)

    Ann-Kathrin Kahle, Katharina Scherschel, Fares-Alexander Alken, and Christian Meyer

    Chapter 13. Management of Reflex Syncope

    13A. Non-pharmacological and Pharmacological Management of Reflex Syncope

    Giulia Rivasi, and Artur Fedorowski

    13B. Cardioneuroablation

    Tolga Aksu, Jeanne M. Du-Fay-de-Lavallaz, and Asad Khan

    13C. Cardiac Pacing in Reflex Syncope

    Michael Liu, Dan Sorajja, and Win-Kuang Shen

    Chapter 14. The Legal Aspects of Syncope

    Frederik J de Lange, and Robert S Sheldon

    Chapter 15. Syncope & Falls in Older Adults

    Desmond O’ Donnell, and Rose Anne Kenny 


    Tolga Aksu, MD, FESC, FEHRA

    Dr, Aksu is a Professor of Cardiology. Currently a member of the Department of Cardiology and Director of Clinical Electrophysiology at the Yeditepe University Hospital in Turkey. Dr. Aksu is clinically interested in invasive electrophysiology, device implantation and catheter ablation therapies. Special interest areas include Atrial fibrillation and cardioneuroablation, and has been a pioneer and advocate in this field. Dr. Aksu has published more than 130 international scientific publications. He is an Associate Editor of Journal of Electrocardiology and SoMe Editor of JICE. He is also a member of the Editorial Board of World Journal of Cardiology, Medicine Journal, Journal of Atrial Fibrillation, and Journal of Cardiac Arrhythmias.

    Carlos A. Morillo, MD, FRCPC, FACC, FHRS, FESC

    Prof Carlos A. Morillo is a cardiac electrophysiologist, and served as the Chief Division of Cardiology (2015-2022) at the Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada, and currently on an academic sabbatical leave at the Molecular and Novel Arrhythmia Mechanisms group at the Centro Nacional de Investigaciones Cardiovaculares (CNIC) in Madrid, Spain. He has been involved in syncope research since 1986, and has extensively investigated the mechanisms of  neurally mediated syncope and participated and led several landmark clinical trials related with the diagnosis and management of vasovagal syncope including the VPS, POST and SPAIN trials. Prof Morillo has published over 350 peered reviewed articles and has also participated in several syncope guidelines from the ESC, ACC, AHA, HRS and Canadian Society of Cardiology. Prof Morillo's key research areas are related to the development of clinical trials in the area syncope, cardiac arrhythmias, AF ablation, screening and detection of AF in varied populations, and treatment of Chagas Disease.