1st Edition

Synthesis Green Metrics Problems, Exercises, and Solutions

By John Andraos Copyright 2019
    526 Pages 490 B/W Illustrations
    by CRC Press

    526 Pages 490 B/W Illustrations
    by CRC Press

    Green chemistry promotes improved syntheses as an intellectual endeavour that can have a great impact both on preserving and utilizing our planet’s finite resources and the quality of human life. This masterful accomplishment provides an evaluation of environmental impact metrics according to life cycle assessment analysis based on the Mackay compartment environmental model and Guinée environmental impact potentials formalism. Assumptions, limitations, and dealing with missing data are addressed. Best literature resources for finding key toxicological parameters are provided and applied to individual reactions as well as entire synthesis plans, in order to target molecules of interest.

    Key Features:

    • Provides an evaluation of environmental impact metrics according to life cycle assessment analysis
    • Summarises safety-hazard metrics according to the same model as life cycle assessment including occupational exposure limits, risk phrases, flammability, and other physical parameters
    • The book will be useful in a range of chemistry courses, from undergraduate to advanced graduate courses, whether based in lectures, tutorials or laboratory experiments


    Chapter 1 Introduction

    Chapter 2 Synthesis Plan Analysis

    Chapter 3 Environmental Impact Metrics

    Chapter 4 Safety-Hazard Impact Metrics

    Chapter 5 Energy Metrics

    Chapter 6 Algorithms

    Chapter 7 Examples from the Chemical Industry

    Appendix: Other Terminologies



    John Andraos earned a Ph.D. in 1992 from the University of Toronto in physical organic chemistry. He then did post-doctoral work at the University of Ottawa and at The University of Queensland studying kinetics of reactions in heterogeneous media and cumulene intermediates in low temperature matrices, respectively. Since his appointment as Lecturer and Course Director at York University (1999-2009) he has taught and developed courses in organic chemistry. In 2002 he launched the first industrial and "green" chemistry course in the history of the Department of Chemistry at York. His current research is broadly defined as reaction optimization and discovery. His undertaking of an ambitious project to construct a database of synthesis plans fully quantified by green metrics analysis for pharmaceuticals, important natural products, dyestuffs, agrichemicals, and molecules of theoretical interest culminated in the publication of "The Algebra of Organic Synthesis: green metrics, design strategy, route selection, and optimization" (CRC Press-Taylor & Francis, 2012). He also co-edited "Green Syntheses Volume 1" (CRC Press-Taylor & Francis, 2014) with Prof. Pietro Tundo (University of Venice) which is the first resource of reliable green chemistry experiments that have been checked for greenness claims by rigorous material efficiency metrics analysis.