1st Edition

Synthetic Gene Network Modeling, Analysis and Robust Design Methods

By Bor-Sen Chen, Yu-Chao Wang Copyright 2014
    216 Pages 26 Color & 20 B/W Illustrations
    by CRC Press

    This book develops a rational design and systematic approach to construct a gene network with desired behaviors. In order to achieve this goal, the registry of standard biological parts and experimental techniques are introduced at first. Then these biological components are characterized by a standard modeling method and collected in the component libraries, which can be efficiently reused in engineering synthetic gene networks. Based on the system theory, some design specifications are provided to engineer the synthetic gene networks to robustly track the desired trajectory by employing the component libraries.

    General introduction
    Survey of synthetic gene networks
    Experimental techniques for engineering synthetic gene networks
    Mathematical models and design specifications in synthetic gene networks
    Robust synthetic biology designs based on system dynamic methods
    Construction of promoter library and RBS library for synthesis of gene networks
    Robust synthetic gene network designs based on library-search method
    Next-generation synthetic gene network


    Bor-Sen Chen, Yu-Chao Wang