Synthetic Sequences in Organic Chemistry  book cover
1st Edition

Synthetic Sequences in Organic Chemistry

  • Available for pre-order on June 9, 2023. Item will ship after June 30, 2023
ISBN 9781032502939
June 30, 2023 Forthcoming by CRC Press
192 Pages 238 Color Illustrations

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Book Description

Drawing on the vast amount of experience the author has gained from working in industrial and university laboratories, this collection of excerpt reports contains essential details from literature relevant to the synthesis of compounds on a milligram to kilogram scale. The excerpts are composed using ChemDraw software and compiled in a Word document. A number of the compounds that have eluded efficient preparation in the past are now presented. Material which will improve any chemist's existing synthetic methodology can be found here. Each of the six chapters, with eighty excerpts, illustrates a novel application of syntheses selected from twenty first century literature.

Table of Contents

1.Non-Natural products Thienodiazapinone Anticancer Agents
Fluorinated Liquid Crystal
B-Hydroxytyrosine Tripeptide
Aza Crown Ether : Chiral PTC Agent Triple C-13 Pyridoxine
F-18 Radiotracer Roadmap
Technecium Radiotracer
Cytotoxic Ferrocene Analog
Pyridine Aza Crown Hybrid Chelate

2. Formation and Transformation of Structural Moieties and Functional Groups

1,3-Diarylindene Synthesis
Nitriles from Terminal Alkynes
Thiocyanate Transformations
Dehydrogenative Cross Coupling
4-Methoxy Phthalaldehyde
Glutamate Neuroantagonist
10 Undecylenic Acid
Pentafluorosulfanyl – SARM
Tetrahydroquinoline Synthesis
1,3,5-Triol Motif


3. Natural Products
3-epi Jurenolide C
Acremens F, A, and B
Altoscholarsine C and D
Cryptochiral I -- Four Compounds
Cryptochiral II -- Leafminer Phermone

4. Diversification and Simplification

Two Aminophilic Reagents
Truncated Abyssomicin
Knoevenagle Adducts of Fuligonadin
Core of the Calliciphylenes
Beta Beta-Disubstituted Amino Acid
Conformationally Restricted Epothilone
Kaurene Derivative
Canolidine Simplified
Annulated Thiophene
Modified Pyrrazolaquinolineone Drug
The Bispiro Core of Molinol A
Sphingosine Analogs
Vancomycin Aminoglycal

5. Name Reactions

Undesired Product
Aza-Claisen Rearrangement
Petasis Reaction : Heterospirocycle
Methyl Carlactonate
Robinson Reaction Products I, II, and III
NHC Catalyzed Aldehyde Coupling
Strecker Reaction : Cyclic Aminonitriles
Oxa-Bridged Tetracyclic Framework
Achmatowicz – Decytospolide
The Quaternary Core of Lyngbyatoxin A
Stetter Michael

6. Variations on a Synthetic Sequence Acids
An Erythrina Alkaloid
Carboxylic Acid Derivatives of Lactams
3-(R)-Hydroxyglutamic Acid
(R) and (S)-(n-Propyl)-Butyrolactone
Indole – Quinoline Hybrids
Isoquinoline Alkaloid
Lilly of the Valley Odorant
Enzyme Receptor ligand
Altersolonols A and N
Teneraic Acid
Biliruben Metabolites

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Dr Jerome Zoeller graduated with a B.S. Degree in Chemistry and began work at Rohm & Haas Co. in Philadelphia, in applications and process development with acrylic emulsion polymers. Graduate study followed at The University of Texas at Austin, with research work in Physical Organic Chemistry. Upon completing the Ph.D. program, he went on for two years as a Postdoctoral Research Fellow in organometallic chemistry. In the 70’s, at The Southwest Foundation for Research and Education (now The Southwest Biomedical Research Institute) he developed synthetic methods for derivatives of cortisol to be used in a study of the effects of steroids in the primate brain. In this decade he also lectured in Chemistry at The University of Texas at San Antonio and at Trinity University. A change in career objectives occurred, in which he studied Fuel Science at The Pennsylvania State University. With his research on coal liquefaction, he was awarded a M.S Degree in Material Science. This specialty was pursued at Texas A&M University where he worked in projects involving the use of Plasma Desorption Mass Spectroscopy in the study of coal structure. The research work at Texas A&M widened to include the characterization of Texas lignite using spectroscopic and oxidative methods, the scope of ruthenum tetroxide oxidative degradation, and the isolation of a rare terpene from a native scrub brush. Upon retiring from A&M, he moved to Targacept Inc., a pharma startup. The work here in medicinal chemistry, led to the formulation of this professional text.