1st Edition

Target Organ Toxicity
Volume 1




ISBN 9780367256456
Published June 30, 2020 by CRC Press
230 Pages

USD $200.00

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Book Description

First published in 1986: The purpose of these volumes is to provide a valuable reference for established investigators and postgraduate students in toxicology.

Table of Contents

1. Basic Principles of Target Organ Toxicity

Gerald M. Cohen

2. Role of Pharmacokinetics in Rationalizing Tissue Distribution

J. Brian Houston

3. The Role of Metabolic Activation in Target Organ Toxicity

John Caldwell, Susan A. Sangster, and J. David Sutton

4. Role of Excretion

Walter G. Levine

5. Species Variation in Target Organ Toxicity

J.C. Connelly and James W. Bridges

6. The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity

Steven D. Aust

7. Role of Key Defense Systems in Target Organ Toxicity

Toshihisa Ishikawa, Theodore P.M. Akerboom, and Helmut Sies

8. The Liver as a Target Organ for Toxicity

J.A. Timbrell

9. The Nervous System as a Target Organ for Toxicity

Rebecca J. Anderson, Rudy J. Richardson, and Bradley W. Schwab

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Editor(s)

Biography

Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.