1st Edition

Target Organ Toxicity Volume 1

Edited By Gerald M. Cohen Copyright 1986

    First published in 1986: The purpose of these volumes is to provide a valuable reference for established investigators and postgraduate students in toxicology.

    1. Basic Principles of Target Organ Toxicity

    Gerald M. Cohen

    2. Role of Pharmacokinetics in Rationalizing Tissue Distribution

    J. Brian Houston

    3. The Role of Metabolic Activation in Target Organ Toxicity

    John Caldwell, Susan A. Sangster, and J. David Sutton

    4. Role of Excretion

    Walter G. Levine

    5. Species Variation in Target Organ Toxicity

    J.C. Connelly and James W. Bridges

    6. The Importance of Tissue-Specific Biochemistry in the Determination of Target Organ Toxicity

    Steven D. Aust

    7. Role of Key Defense Systems in Target Organ Toxicity

    Toshihisa Ishikawa, Theodore P.M. Akerboom, and Helmut Sies

    8. The Liver as a Target Organ for Toxicity

    J.A. Timbrell

    9. The Nervous System as a Target Organ for Toxicity

    Rebecca J. Anderson, Rudy J. Richardson, and Bradley W. Schwab

    Biography

    Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.