First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
Table of Contents
1. The Kidney as a Target Organ for Toxicity
Glenn F. Rush and Jerry B. Hook
2. Cardiac Toxicity
T. Balazs et al.
3. The Lung as a Target Organ for Toxicity
Lewis L. Smith and Benoit Nemery
4. Target Organ Toxicity: The Male Reproductive System
5. Toxic Effects on the Female Reproductive System
Michael H. Briggs
6. The Eye
7. The Inner Ear
Ernest S. Harpur
8. The Endocrine Pancreas as a Target Organ for Toxicity
Willy J. Malaise
9. Structural DNA Modifications and DNA Repair in Organ-Specific Tumor Induction
P. Kleihues and Otmar Wiestler
10. Organ Specificity in Tumor Initiation and Comple Carcinogenesis (Including Species Variation)
Maurice M. Coombs
Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.