First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.
1. The Kidney as a Target Organ for Toxicity
Glenn F. Rush and Jerry B. Hook
2. Cardiac Toxicity
T. Balazs et al.
3. The Lung as a Target Organ for Toxicity
Lewis L. Smith and Benoit Nemery
4. Target Organ Toxicity: The Male Reproductive System
5. Toxic Effects on the Female Reproductive System
Michael H. Briggs
6. The Eye
7. The Inner Ear
Ernest S. Harpur
8. The Endocrine Pancreas as a Target Organ for Toxicity
Willy J. Malaise
9. Structural DNA Modifications and DNA Repair in Organ-Specific Tumor Induction
P. Kleihues and Otmar Wiestler
10. Organ Specificity in Tumor Initiation and Comple Carcinogenesis (Including Species Variation)
Maurice M. Coombs
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