Target Organ Toxicity: Volume 2, 1st Edition (Hardback) book cover

Target Organ Toxicity

Volume 2, 1st Edition

Edited by Gerald M. Cohen

CRC Press

233 pages

Purchasing Options:$ = USD
Hardback: 9780367258719
pub: 2020-03-31
SAVE ~$39.80
Available for pre-order. Item will ship after 31st March 2020

FREE Standard Shipping!


First published in 1986: This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Table of Contents

1. The Kidney as a Target Organ for Toxicity

Glenn F. Rush and Jerry B. Hook

2. Cardiac Toxicity

T. Balazs et al.

3. The Lung as a Target Organ for Toxicity

Lewis L. Smith and Benoit Nemery

4. Target Organ Toxicity: The Male Reproductive System

H.D.M. Moore

5. Toxic Effects on the Female Reproductive System

Michael H. Briggs

6. The Eye

Ralph Heywood

7. The Inner Ear

Ernest S. Harpur

8. The Endocrine Pancreas as a Target Organ for Toxicity

Willy J. Malaise

9. Structural DNA Modifications and DNA Repair in Organ-Specific Tumor Induction

P. Kleihues and Otmar Wiestler

10. Organ Specificity in Tumor Initiation and Comple Carcinogenesis (Including Species Variation)

Maurice M. Coombs

About the Editor

Gerald M. Cohen Ph.D. is Head of the Toxicology Unit, Department of Pharmacology, The School of Pharmacy, University of London.

About the Series

Routledge Revivals

Are there elusive titles that you need and have been trying to source for years but thought that you would never be able to find?

Well this may be the end of your quest – here is a fantastic opportunity for you to discover past brilliance and purchase previously out of print and unavailable titles by some of the world’s most eminent academic scholars.

Drawing from over 100 years of innovative, cutting-edge publishing, Routledge Revivals is an exciting programme whereby key titles from the distinguished and extensive backlist of the many acclaimed imprints associated with Routledge will be re-issued.

The programme draws upon the illustrious backlists of Kegan Paul, Trench & Trubner, Routledge & Kegan Paul, Methuen, Allen & Unwin and Routledge itself.

Routledge Revivals spans the whole of the Humanities and Social Sciences, and includes works by some of the world’s greatest thinkers including Emile Durkheim, Max Weber, Simone Weil, Martin Buber, Karl Jaspers and Max Beloff.

If you are interested in Revivals in the Behavioral Sciences, please visit

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Toxicology
SCIENCE / Life Sciences / General