Target Organ Toxicity, Volume I: 1st Edition (Hardback) book cover

Target Organ Toxicity, Volume I

1st Edition

By Cohen

CRC Press

240 pages

Purchasing Options:$ = USD
Hardback: 9780849357756
pub: 1986-08-31
SAVE ~$101.00
Currently out of stock

FREE Standard Shipping!


This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

Table of Contents


Basic Principles of Target Organ Toxicity. Role of Pharmacokinetics in Rationalizing Tissue Distortion. Role of Metabolic Activation in Target Organ Toxicity. Role of Excretion. Species Variation in Target Organ Toxicity. Importance of Tissue-Specific Biochemistry in Determination of Target Organ Toxicity. Role of Key Defense Systems in Target Organ Toxicity. Liver as a Organ for Toxicity. Index.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Toxicology
SCIENCE / Life Sciences / General