Targeted Delivery of Small and Macromolecular Drugs  book cover
1st Edition

Targeted Delivery of Small and Macromolecular Drugs

ISBN 9781138114517
Published July 26, 2017 by CRC Press
630 Pages 185 B/W Illustrations

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Book Description

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice.

Focusing on the delivery technologies that utilize both systemic and local routes of administration, Targeted Delivery of Small and Macromolecular Drugs brings together field experts who summarize current progress and discuss novel ideas currently being explored to overcome these challenges.

The contributors discuss the most promising strategies for drug targeting and also examine targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including:

    • Active targeting
    • Nucleic acid delivery and targeting
    • Intracellular/organelle-specific strategies
    • Prodrug strategies
    • Organ or tissue-specific drug delivery
    • Drug-polymer conjugates and micelles
    • Stimuli-responsive systems

The book demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.

Table of Contents

Therapeutic Potential of Targeted Drug Delivery
Ajit S. Narang and Ram I. Mahato

Antibody Therapies for Liver Malignancy and Transplantation
John M. Luk and Kwong-Fai Wong
Transferrin Receptor–Mediated Transcytosis in Intestinal Epithelial Cells for Gastrointestinal Absorption of Protein Drugs
Nurmamet Amet, Xiaoying Chen, Hsin-Fang Lee, Jennica Zaro, and Wei-Chiang Shen
Ionizing Radiation for Tumor-Targeted Drug Delivery
Roberto Diaz, Li Zhou, and Dennis E. Hallahan

Recent Advances in Gene Expression and Delivery Systems
Ravikiran Panakanti and Ram I. Mahato
Cellular Barriers for Nucleic Acid Delivery and Targeting
Arto Urtti
Targeted Delivery Systems of Nonviral Nucleic Acid–Based Therapeutics
Ga Yong Shim, Eun-Joong Kim, Rae Sung Chang, Han Young Lee, and Yu-Kyoung Oh
Delivery and Targeting of Oligonucleotides and siRNA
Ningning Yang and Ram I. Mahato
Liposomes for Nonviral Gene Delivery
Jiasheng Tu, Yan Shen, Hui Pang, and Yubing Yu

Delivering the Bullet to the Right Intracellular Target: A Cellular Perspective on Drug Delivery
Maria Teresa Tarragó-Trani and Brian Storrie
Mitochondria-Targeted Drug Delivery
Volkmar Weissig and Gerard G. M. D’Souza

Site-Specific Prodrug Activation Strategies for Targeted Drug Action
Mark D. Erion
Enzyme-Activated Prodrug Strategies for Targeted Drug Action
Jarkko Rautio, Krista Laine, Lanyan Fang, Bing Han, Kristiina Huttunen, and Duxin Sun

Targeting Colon and Kidney: Pathophysiological Determinants of Design Strategy
Ajit S. Narang and Ram I. Mahato
Principles and Practice of Pulmonary Drug Delivery
Vivek Gupta, Chandan Thomas, and Fakhrul Ahsan
Recent Advances in Ocular Drug Delivery: Role of Transporters, Receptors, and Nanocarriers
Gyan P. Mishra, Ripal Gaudana, Viral M. Tamboli, and Ashim K. Mitra

Injectable Polymers for Regional Drug Delivery
Rajendra P. Pawar, Niteen R. Shinde, Narsinha M. Andurkar, Satish A. Dake, and Abraham J. Domb
Polymer–Drug Conjugates
Lucienne Juillerat-Jeanneret and Feride Cengelli
Polymer Micelles for Drug Delivery
Sungwon Kim and Kinam Park

Multifunctional Stimuli–Responsive Nanoparticles for Targeted Delivery of Small and Macromolecular Therapeutics
Srinivas Ganta, Arun Iyer, and Mansoor Amiji
Physiological Stress Responsive Gene Regulation Systems for Tissue Targeting
Hyun Ah Kim and Minhyung Lee 

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Ajit S. Narang works for the Bristol-Myers Squibb, Co. in New Brunswick, New Jersey, in the biopharmaceutical aspects of drug delivery. He has more than eight years of experience in the pharmaceutical industry in the development of oral dosage forms and drug delivery platforms. In addition to the Bristol-Myers Squibb, Co., he has worked for Ranbaxy Research Labs (currently a subsidiary of Daiichi Sankyo, Japan) in Gurgaon, India, and Morton Grove Pharmaceuticals (currently a subsidiary of Wockhardt USA LLC, Parsippany, New Jersey) in Vernon Hills, Illinois. He has more than 35 publications and three pending patent applications, and has contributed to the development of several marketed drug products. 

Ram I. Mahato is a full-time professor in the Department of Pharmaceutical Sciences at the University of Health Science Center, Memphis, Tennessee. He was a research assistant professor at the University of Utah, Salt Lake City; a senior scientist at GeneMedicine, Inc., The Woodland, Texas; and a postdoctoral fellow at the University of Southern California in Los Angeles, Washington University in St. Louis, and Kyoto University, Japan. He is an author or coauthor of 79 peer-reviewed articles and book chapters, and has edited/written three books. He is also a special features editor of Pharmaceutical Research and serves on the editorial boards of the Journal of Drug Targeting, Expert Opinion on Drug Delivery, and Transplantation and Risk Management. His research includes delivery and targeting of small molecules, oligonucleotides, siRNA, and genes.