472 Pages
by
CRC Press
472 Pages
by
CRC Press
386 Pages
by
CRC Press
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Taxol, originally derived from the North American Yew tree in 1971, is well-known worldwide as a powerful anticancer agent. Mechanistically, it has a unique microtubule stabilizing activity, and was clinically developed as a therapeutic agent in the treatment of breast and ovarian cancers at the National Cancer Institute, Washington D.C., USA. In this volume, the authors provide an authoritative... Read more
1. Introduction 2. Biosynthesis of Taxoids 3. Taxoids Occurring in the genus Taxus 4. Physical Methods for Identifying the Structures of Taxoids 5. Plant Tissue Culture of Taxoids 6. The Commercial Cultivation of Taxus Species and Production of Taxoids 7. Analytical Aspects of Taxoids 8. Chemistry of Taxol and Related Taxoids 9. Total Synthesis of Taxoids 10. Structure-Activity Relationships of Taxoids 11. Pre-clinical and Clinical Investigation of the Taxanes 12. Paclitaxel Content of Yews in Ireland
Biography
Hideji Itokawa, Kuo-Hsiung Lee
