Telomeres Biomarkers of a Healthy Life and Successful Aging

Part 1: AGING

1. Telomere’s Length in Aging

2. Telomere Length as a Marker of Biological Age

3. Computational Tools for Telomere Length Measurement

5. Diet as a Strategy to Lengthen Life Expectancy

6. The First Steps Towards Balanced Eating

7. Fasting and Telomeres

8. The Impact of Exercise on Telomere Length

9. Telomere Shortening: A Link Between Substances of Abuse and Accelerated Senescence

10. Telomere Length as Potential Metal Exposure Biomarker: State Of The Art And Perspectives

11. Telomere’s Association with Diseases

12. Telomere Length and Metabolomics in Autoimmune Diseases

13. Osteoarthritis

14. Microbiome

15. Intestinal Microbiota and Human Telomere Length: A Dynamic Crosstalk Between Two Worlds

16. Cardiovascular Diseases

17. Decelerating Cardiovascular Aging: Diet, Exercise, and Medication

18. Male and Female Infertility

19. Telomere Length and Human Carcinogenesis: Liable or Random Finding?

20. Telomere Length Biology in Blood Disorders and Childhood Cancer

21. Skin aging

22. Telomeres, Telomerase and Shelterin Complex: Promising Drug Targets for Longevity, Age-Related Diseases, and Cancer

23. Therapeutic Targeting of Telomerase

Biography

Aristidis Tsatsakis is the director of the Department of Toxicology and Forensic Sciences at the Medical School of the University of Crete and the University Hospital of Heraklion, Greece. He is the founder and chief scientific leader of the University of Crete spinoff company ToxPlus S.A. and the startup LifePlus. Prof. Tsatsakis’ motivation logo “Toxicology addresses society’s real-life risks for sustainable health and wellbeing” is indicated on the EUROTOX 2025 website.

“This book unsparingly lays out the challenges of worldwide aging and its growing and possibly insurmountable health and economic challenges. A powerful boost to the credibility of the book is its rigorous examination of the validity of the methods of telomere impact assessment, which facilitates understanding of what has been determined of the impact of our lifestyles on our telomere processes and also the effects of some major disease states.”

 Michael D. Coleman 

Aston University, United Kingdom

 

 

“The book provides state-of-the-art information and deepens the understanding of telomere importance in healthy life and aging written by internationally recognized experts in their own field. It provides a timely update on the latest research outcomes and scientific breakthroughs in the field of telomeres, and it should be of interest to students, researchers, experts in various disciplines and the general reader.”

Michael Aschner

Albert Einstein College of Medicine, USA

 

“This text distinguishes itself with an extensive and insightful analysis that seamlessly connects fundamental biological understanding with the prospects of therapeutic intervention. By bridging the gap between basic science and clinical application, the book introduces a groundbreaking approach to exploring the potential of telomere science in enhancing health span and offers a holistic view of the current landscape of research and therapy development. Designed with a broad audience in mind, this book is an invaluable resource for a diverse range of readers, from researchers and clinicians deeply entrenched in the study of genetics and aging, to those with a keen interest in the broader implications of telomere science for preventive medicine.” 

Thomas Hartung

Johns Hopkins Bloomberg School of Public Health, USA

 

 

“Prof. Tsatsakis’ book masterfully demystifies the role of telomeres in dictating the pace of our biological clock through a narrative that is not only scientifically rich but also deeply personal. Each chapter unfolds the intricate dance of telomere replication, a process pivotal to our understanding of aging and the potential onset of senescence.”

Ananya Nag

CEO, Aenaos Life

 

“The book provides state-of-the-art information and deepens understanding of the importance of telomere integrity in maintaining healthy life and aging. The book is written by internationally recognized experts in their fields and provides a timely update on the latest research outcomes and scientific breakthroughs in telomere biology and disease/aging linkage. The comprehensive nature of the book makes it an excellent reference in telomere biology in general and constitutes a must-read for not only students, researchers, and experts in aging but also those in other disciplines as well as the general reader.”

 

Prof. Michael Antoniou

King's College London, UK

Guy's Hospital, London, UK

 

“I highly recommend this book to anyone interested in understanding the complex relationship between our genetic blueprint and environment. This book offers a timely and critical exploration of telomeres and is sure to be of great value to all who seek to promote good health, longevity, and toxicants' role.”

Dr Mohammad Abdollahi

Tehran University of Medical Sciences

 

“Modern progressive scientific advancements have impacted all aspects of human life, even the most sacred such as birth and death.  The discovery of telomeres has provided humanity with unprecedented opportunities to both predict and to control the life expectancy. The book systematizes and details all current knowledge on the aging mechanisms and solutions for their deceleration. These issues concern everyone. Therefore, this edition can be recommended to the widest range of readers.”

 

 

 

Prof. Victor A. Tutelyan

Full Member of the Russian Academy of Sciences and WHO Food Safety Expert