Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach, 1st Edition (Hardback) book cover

Temperature and Toxicology

An Integrative, Comparative, and Environmental Approach, 1st Edition

By Christopher J. Gordon

CRC Press

338 pages | 107 B/W Illus.

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Hardback: 9780849330247
pub: 2005-02-28
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Description

Thermoregulation is vital for survival but the interplay between toxic insults and thermoregulatory mechanisms is often poorly understood. Temperature and Toxicology: An Integrative, Comparative, and Environmental Approach is the first major text to study the integrative thermoregulatory responses of mammals that are exposed to toxicants. Because environmental physiology is also crucial in toxicological responses, this volume also examines the role of environmental temperature in the modulation of cellular mechanisms of toxicity.

The book begins by explaining the importance of temperature in toxicological studies, and how all biological processes are dependent on temperature. It then reviews the basics of temperature regulation in homeotherms and poikilotherms, and addresses whole-animal and in vitro studies related to the effects of temperature on toxicity. The text examines thermoregulatory response to toxic insult, and how responses affect recovery and potential survival. It describes hypothermic response in rodents to febrile and hyperthermic reactions in humans, and discusses the relevance of heat and cold stress on human exposures to airborne pollutants and other toxicants.

This volume provides an extensive comparison of physiological responses of invertebrates, fish, amphibians, and mammals, and focuses on the impact of endocrine disruption. It then considers how toxicants and thermal stress cause the expression of stress proteins, followed by a study of the impact of genetic variability. The book concludes with an examination of thermoregulatory response to natural toxins and venoms.

Table of Contents

Introduction

Principles of Temperature Regulation

Acute Toxic Thermoregulatory Responses

Temperature Effects on Chemical Toxicity

Regulated Hypothermia: An Adaptive Response to Toxic Insult

Fever and Hyperthermia

Environmental Stress

Comparative Physiological Responses

Genetic Variability and Molecular Markers

Toxins and Venoms

Subject Categories

BISAC Subject Codes/Headings:
MED005000
MEDICAL / Anatomy
MED071000
MEDICAL / Pharmacology
MED096000
MEDICAL / Toxicology