Terahertz Biomedical Science and Technology  book cover
1st Edition

Terahertz Biomedical Science and Technology

Edited By

Joo-Hiuk Son

ISBN 9780367576127
Published June 30, 2020 by CRC Press
377 Pages

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Book Description

A number of applications including scientific spectroscopy, security screening, and medical imaging have benefitted from the development and utilization of new and emerging terahertz (THz) generation and detection techniques. Exploring recent discoveries and the advancements of biological behaviors through THz spectroscopy and imaging and the development of THz medical techniques, Terahertz Biomedical Science and Technology contains contributions from scientists and researchers in the terahertz biomedical field and is exclusively dedicated to new and emerging terahertz biomedical research and applications.

This text offers an assessment of terahertz technology, and provides a compilation of fundamental biological studies conducted using terahertz waves. It introduces THz electromagnetic waves as a new tool for convergent studies, includes laser-based generation techniques and solid-state devices, contains a number of detectors, and discusses high-field generation methods. The material covers recent advancements in terahertz imaging for medical applications—most specifically in cancer diagnosis—reviewing the current status of the THz imaging technique for diagnosing cancers, and exploring the potential medical applications of THz radiation. It also considers the development of future medical applications using terahertz technology.

  • Summarizes the recent progress made in THz waveguides, which are absolutely essential in the development of THz endoscopes

  • Describes the dynamic imaging of drug absorption in skin, exploiting the sensitivity of THz waves to pharmaceutical materials

  • Explores the principle and applications of THz molecular imaging techniques using nanoparticle probes

Scientists and engineers involved in biological research and medical applications using optical techniques, as well as graduate students and instructors in optics, physics, electrical engineering, biology, chemistry, and medicine can benefit from this text which highlights new and emerging biomedical studies utilizing novel THz wave techniques.

Table of Contents

Introduction to Biomedical Studies Using Terahertz Waves. Section I Terahertz Technology. Terahertz Sources and Detectors. Tabletop High-Power Terahertz Pulse Generation Techniques. Terahertz Imaging and Tomography Techniques. Compact Solid-State Electronic Terahertz Devices and Circuits. Waveguides for Terahertz Endoscopy. Section II Fundamental Biological Studies by Terahertz Waves. Terahertz Characteristics of Water and Liquids. Probing Solvation Dynamics by Terahertz Absorption Spectroscopy. Terahertz Spectroscopy of Biological Molecules. Terahertz Spectroscopic Insight into the Structure–Function Relation in Protein Molecules. Protein Dielectric Response at Terahertz Frequencies. Nonlinear Interaction of Amino Acids and Proteins with Terahertz Waves. Biological Effects of Broadband Terahertz Pulses. Section III Terahertz Biomedical Applications. Terahertz Dynamic Imaging of Skin Drug Absorption. Terahertz for the Detection of Skin Cancer. Application of Terahertz Technology to Breast Cancer. Frozen Terahertz Imaging of Excised Oral Cancer. Terahertz Molecular Imaging and Its Clinical Applications. Prospects in Medical Applications of Terahertz Waves and Conclusions. Index.

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Joo-Hiuk Son received his BS and MS in electronics engineering from Seoul National University, Seoul, Republic of Korea, in 1986 and 1988, respectively, and his PhD in electrical engineering from the University of Michigan, Ann Arbor, in 1994. In the early years, his research was focused on the characterization of electrical and optical properties of semiconductors and various nanosized materials. In recent years, his interest has shifted to terahertz electromagnetic interactions with biological materials and their applications in medicine. Combining his expertise on nanomaterials and terahertz medical diagnosis, he invented a highly sensitive terahertz molecular imaging technique using nanoparticle probes.


"A wonderful introduction and a lasting reference for those who wish to survey and understand the growing interest in this burgeoning technological field."
—From the Foreword by Peter H. Siegel, Senior Scientist, California Institute of Technology and NASA Jet Propulsion Laboratory