5th Edition

Textbook of Drug Design and Discovery

    452 Pages 327 Color Illustrations
    by CRC Press

    450 Pages 327 Color Illustrations
    by CRC Press

    Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

    Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

    The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding).

    The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.

    Introduction to Drug Design and Discovery
    Ulf Madsen and Povl Krogsgaard-Larsen

    Molecular Recognition
    Thomas Balle and Tommy Liljefors

    Ligand-Based Drug Design
    Erica S. Burnell, David E. Jane, and Robert J. Thatcher

    Biostructure-Based Drug Design
    Flemming Steen Jørgensen and Jette Sandholm Kastrup

    Drug-Like Properties and Decision Making in Medicinal Chemistry
    Jan Kehler, Lars Kyhn Rasmussen, and Morten Jørgensen

    Chemical Biology
    Louise Albertsen and Kristian Strømgaard

    Natural Products in Drug Discovery
    Guy T. Carter

    In Vivo Imaging in Drug Discovery
    Jesper L. Kristensen and Matthias M. Herth

    Peptide and Protein Drug Design
    Jesper Lau and Søren Østergaard

    Prodrugs in Drug Design and Development
    Jarkko Rautio and Krista Laine

    Enzyme Inhibitors: Biostructure- and Mechanism-Based Design
    Robert A. Copeland and P. Ann Boriack-Sjodin

    Receptors: Structure, Function, and Pharmacology
    Hans Bräuner-Osborne

    Ion Channels: Structure and Function
    Søren-Peter Olesen, Bo Hjorth Bentzen, and Daniel B. Timmermann

    Neurotransmitter Transporters: Structure, Function, and Drug Binding
    Claus J. Løland and Ulrik Gether

    GABA and Glutamic Acid Receptor and Transporter Ligands
    Bente Frølund and Lennart Bunch

    Anders A. Jensen

    Histamine Receptors
    Iwan de Esch, Henk Timmerman, and Rob Leurs

    Dopamine and Serotonin
    Benny Bang-Andersen, Lena Tagmose, and Klaus P. Bøgesø

    Opioid and Cannabinoid Receptors
    Rasmus P. Clausen and Harald S. Hansen

    Neglected Diseases
    Søren B. Christensen and Ib C. Bygbjerg

    Anticancer Agents
    Fredrik Björkling, José Moreira, and Jan Stenvang

    Targeting Receptor Tyrosine Kinases
    Bo Falck Hansen and Steen Gammeltoft

    Smitha Rao C.V., Piet Herdewijn, and Anastassios Economou


    Kristian Stromgaard, Povl Krogsgaard-Larsen, Ulf Madsen