Textbook of Ion Channels : Three Volume Set book cover
1st Edition

Textbook of Ion Channels
Three Volume Set

  • Available for pre-order on April 27, 2023. Item will ship after May 18, 2023
ISBN 9781032424286
May 18, 2023 Forthcoming by CRC Press
1064 Pages 281 Color & 33 B/W Illustrations

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Book Description

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.

All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Table of Contents

Volume I  1. Ion Selectivity and Conductance  2. Voltage-Dependent Gating of Ion Channels  3. Ligand-Dependent Gating Mechanism  4. Mechanosensitive Channels and Their Emerging Gating Mechanisms  5. Inactivation and Desensitization  6. Ion Channel Inhibitors  7. Expression of Channels in Heterologous Systems and Voltage Clamp Recordings of Macroscopic Currents  8. Patch Clamping and Single-Channel Analysis  9. Patch Clamp Recordings from Native Cells and Isolation of Membrane Currents  10. Models of Ion Channel Gating  11. Investigating Ion Channel Structure and Dynamics Using Fluorescence Spectroscopy  12. Ion Channel Structural Biology in the Era of Single Particle Cryo-EM  13. Protein Crystallography  14. Rosetta Structural Modeling  15. Molecular Dynamics  16. Genetic Models and Transgenics  17. EPR and DEER Spectroscopy  Volume II  1. Taxonomy and Evolution of Ion Channels  2. Voltage-Gated Sodium Channels  3. Voltage-Gated Calcium Channels  4. Voltage-Gated Potassium Channels  5. ERG Family of K Channels  6. KCNQ Channels  7. BK Channels  8. Small-Conductance Calcium-Activated Potassium (SK) Channels  9. Inward Rectifier Potassium Channels  10. Two-Pore Domain Potassium Channels  11. Cyclic Nucleotide-Gated Channels  12. HCN Channels  13. CLC Chloride Channels and Transporters  14. Ca-Activated Cl- Channels  15: Acetylcholine Receptors  16. Ionotropic Glutamate Receptors  17. 5-HT3 Receptors  18. GABAA Receptors  19. Glycine Receptors  20. Acid Sensing Ion Channels  21: ENaC Channels  22. TRPC Channels  23. TRPM Channels  24. TRPV Channels  25. Store-Operated CRAC Channels  26. Piezo Channels  27. Ryanodine Receptors  28. Proton Channels  29. P2X Receptors  Volume III  1. Alternative Splicing  2. Calmodulin Regulation of Ion Channels  3. Mechanism of G-protein Regulation of Ion Channels  4. Regulation of Ion Channels by Membrane Lipids  5. Ion Channels of the Heart  6. Ion Channels in Sperm and Eggs  7. Ion Channels in Immune Cells  8. Ion Channels in Epilepsy  9. Ion Channels in Pain  10. Cystic Fibrosis and the CFTR Anion Channels  11. CLC-Related Proteins in Diseases  12. KATP Channels and the Regulation of Insulin Secretion

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Jie Zheng, PhD, is a professor at the University of California Davis School of Medicine, where he has served as a faculty member in the Department of Physiology and Membrane Biology since 2004. Dr. Zheng earned a bachelor’s degree in physiology and biophysics (1988) and a master’s degree in biophysics (1991) at Peking University. He earned a PhD in physiology (1998) at Yale University, where he studied with Dr. Fredrick J. Sigworth on patch-clamp recording, single-channel analysis, and voltage-dependent activation mechanisms. He received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington during 1999–2003, working with Dr. William N. Zagotta on the cyclic nucleotide-gated channels activation mechanism and novel fluorescence techniques for ion channel research. Currently, Dr. Zheng’s research focuses on temperature-sensitive TRP channels.

Matthew C. Trudeau, PhD, is a professor in the Department of Physiology at the University of Maryland School of Medicine in Baltimore, Maryland. He earned a bachelor’s degree in biochemistry and molecular biology in 1992 and a PhD in physiology in 1998 while working with Gail Robertson, PhD, at the University of Wisconsin-Madison. His thesis work was on the properties of voltage-gated potassium channels in the human ether-aì-go-go related gene (hERG) family and the role of these channels in heart disease. Dr. Trudeau was a postdoctoral fellow with William Zagotta, PhD, at the University of Washington and the Howard Hughes Medical Institute (HHMI) in Seattle from 1998 to 2004, where he focused on the molecular physiology of cyclic nucleotide-gated ion channels, the mechanism of their modulation by calcium-calmodulin, and their role in an inherited form of vision loss. Currently, Dr. Trudeau’s work focuses on hERG potassium channels, their biophysical mechanisms, and their role in cardiac physiology and cardiac arrhythmias.