Volume I
Chapter 1: Ion Selectivity and Conductance
Alexander A. Simon, Chen Fan, Dorothy M. Kim, Jason G. McCoy, Crina M. Nimigean
Chapter 2: Voltage-Dependent Gating of Ion Channels
Baron Chanda, Sandipan Chowdhury
Chapter 3: Ligand-Dependent Gating Mechanism
William N. Zagotta
Chapter 4: Mechanosensitive Channels and Their Emerging Gating Mechanisms
Sergei Sukharev, Andriy Anishkin
Chapter 5: Inactivation and Desensitization
William N. Zagotta
Chapter 6: Ion Channel Inhibitors
Matthew J. Marquis, Jon T. Sack
Chapter 7: Expression of Channels in Heterologous Systems and Voltage Clamp Recordings of Macroscopic Currents
Victor De la Rosa, León D. Islas
Chapter 8: Patch Clamping and Single-Channel Analysis
León D. Islas
Chapter 9: Patch Clamp Recordings from Native Cells and Isolation of Membrane Currents
Jeanne Nerbonne
Chapter 10: Models of Ion Channel Gating
Frank T. Horrigan, Toshinori Hoshi
Chapter 11: Investigating Ion Channel Structure and Dynamics Using Fluorescence Spectroscopy
Rikard Blunck
Chapter 12: Ion Channel Structural Biology in the Era of Single Particle Cryo-EM
Jianhua Zhao, Yifan Cheng
Chapter 13: Protein Crystallography
Moshe Giladi, Yoni Haitin
Chapter 14: Rosetta Structural Modeling
Phuong T. Nguyen, Vladimir Yarov-Yarovoy
Chapter 15: Molecular Dynamics
Lucie Delemotte
Chapter 16: Genetic Models and Transgenics
Andrea L. Meredith
Chapter 17: EPR and DEER Spectroscopy
Eric G. B. Evans, Stefan Stoll
Volume II
Chapter 1: Taxonomy and Evolution of Ion Channels
Timothy Jegla, Benjamin T. Simonson
Chapter 2: Voltage-Gated Sodium Channels
William A. Catterall
Chapter 3: Voltage-Gated Calcium Channels
Jacqueline Niu, Henry M. Colecraft
Chapter 4: Voltage-Gated Potassium Channels
Francis I. Valiyaveetil
Chapter 5: ERG Family of K Channels
Sara Codding, Matthew C. Trudeau
Chapter 6: KCNQ Channels
H. Peter Larsson
Chapter 7: BK Channels
Jianmin Cui
Chapter 8: Small-Conductance Calcium-Activated Potassium (SK) Channels
Miao Zhang, Heike Wulff
Chapter 9: Inward Rectifier Potassium Channels
Camden Driggers, Min-Woo Sung, Show-Ling Shyng
Chapter 10: Two-Pore Domain Potassium Channels
Leigh D. Plant, Steve A. N. Goldstein
Chapter 11: Cyclic Nucleotide-Gated Channels
Michael D. Varnum
Chapter 12: HCN Channels
Colin H. Peters, Catherine Proenza
Chapter 13: CLC Chloride Channels and Transporters
Anna K. Koster, Merritt Maduke
Chapter 14: Ca-Activated Cl- Channels
Criss Hartzell
Chapter 15: Acetylcholine Receptors
Cecilia Bouzat, Juan Facundo Chrestia
Chapter 16: Ionotropic Glutamate Receptors
Andrew Plested
Chapter 17: 5-HT3 Receptors
Susanne M. Mesoy, Sarah C. R. Lummis
Chapter 18: GABAA Receptors
Trevor G. Smart
Chapter 19: Glycine Receptors
Josip Ivica, Lucia Sivilotti
Chapter 20: Acid Sensing Ion Channels
Yangyu Wu, Cecilia M. Canessa
Chapter 21: ENaC Channels
Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius
Chapter 22: TRPC Channels
Jin Bin Tian, Michael X. Zhu
Chapter 23: TRPM Channels
David D. McKemy
Chapter 24: TRPV Channels
Tamara Rosenbaum
Chapter 25: Store-Operated CRAC Channels
Murali Prakriya
Chapter 26: Piezo Channels
Jörg Grandl, Bailong Xiao
Chapter 27: Ryanodine Receptors
Jean-Pierre Benitah, Laetitia Pereira, Liheng Yin, Jean-Jacques Mercadier, Marine Gandon-Renard, Almudena Val-Blasco, Romain Perrier, A. M. Gomez
Chapter 28: Proton Channels
Emily R. Liman, I. Scott Ramsey
Chapter 29: P2X Receptors
Kate Dunning, Thomas Grutter
Volume III
Chapter 1: Alternative Splicing
Andrea L. Meredith
Chapter 2: Calmodulin Regulation of Ion Channels
Ivy Dick, David T. Yue, Manu Ben-Johny
Chapter 3: Mechanism of G-protein Regulation of Ion Channels
Kirin D. Gada, Rahul Mahajan, Diomedes E. Logothetis
Chapter 4: Regulation of Ion Channels by Membrane Lipids
Tibor Rohacs
Chapter 5: Ion Channels of the Heart
Donald M. Bers, Eleonora Grandi
Chapter 6: Ion Channels in Sperm and Eggs
Rachel E. Bainbridge, Anne E. Carlson
Chapter 7: Ion Channels in Immune Cells
Michael D. Cahalan, Thomas E. DeCoursey
Chapter 8: Ion Channels in Epilepsy
Jeffrey L. Noebels
Chapter 9: Ion Channels in Pain
Richard Dean, J. P. Johnson
Chapter 10: Cystic Fibrosis and the CFTR Anion Channels
Han-I Yeh, Tzyh-Chang Hwang
Chapter 11: CLC-Related Proteins in Diseases
Allan H. Bretag, Linlin Ma, Deanne H. Hryciw
Chapter 12: KATP Channels and the Regulation of Insulin Secretion
Mike Puljung
Biography
Jie Zheng, PhD, is a professor at the University of California Davis School of Medicine, where he has served as a faculty member in the Department of Physiology and Membrane Biology since 2004. Dr. Zheng earned a bachelor’s degree in physiology and biophysics (1988) and a master’s degree in biophysics (1991) at Peking University. He earned a PhD in physiology (1998) at Yale University, where he studied with Dr. Fredrick J. Sigworth on patch-clamp recording, single-channel analysis, and voltage-dependent activation mechanisms. He received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington during 1999–2003, working with Dr. William N. Zagotta on the cyclic nucleotide-gated channels activation mechanism and novel fluorescence techniques for ion channel research. Currently, Dr. Zheng’s research focuses on temperature-sensitive TRP channels.
Matthew C. Trudeau, PhD, is a professor in the Department of Physiology at the University of Maryland School of Medicine in Baltimore, Maryland. He earned a bachelor’s degree in biochemistry and molecular biology in 1992 and a PhD in physiology in 1998 while working with Gail Robertson, PhD, at the University of Wisconsin-Madison. His thesis work was on the properties of voltage-gated potassium channels in the human ether-aì-go-go related gene (hERG) family and the role of these channels in heart disease. Dr. Trudeau was a postdoctoral fellow with William Zagotta, PhD, at the University of Washington and the Howard Hughes Medical Institute (HHMI) in Seattle from 1998 to 2004, where he focused on the molecular physiology of cyclic nucleotide-gated ion channels, the mechanism of their modulation by calcium-calmodulin, and their role in an inherited form of vision loss. Currently, Dr. Trudeau’s work focuses on hERG potassium channels, their biophysical mechanisms, and their role in cardiac physiology and cardiac arrhythmias.
