1st Edition

The Aspergilli Genomics, Medical Aspects, Biotechnology, and Research Methods

Edited By Gustavo H. Goldman, Stephen A. Osmani Copyright 2008
    576 Pages 88 B/W Illustrations
    by CRC Press

    With high-quality genome sequences for the important and ubiquitous Aspergilli now available, increased opportunities arise for the further understanding of its gene function, interaction, expression, and evolution. The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods provides a comprehensive analysis of the research that reveals the main biological attributes of these species. The co-editors are a particularly proficient and prolific pair with long track records of scientific productivity.

    The book sets the stage with a discussion of basic biology, examining the data on the structure of genomes and comparing the genetic map and annotation methodology. It includes a comparison of metabolic abilities among different Aspergillus spp. and other species, then covers areas such as comparative biology, pathogenic properties, and metabolic capabilities of the Aspergilli. The book reviews established techniques and new methodologies for the post-genomic era in Aspergillus spp. It comes with a CD containing color illustrations to supplement the text.

    Filling the need for centralized information on a genus that has important economic impacts on agriculture, human health, industry, and pharmacology, the book presents a wide range of data, collected and arranged into one convenient resource. Written by a team of international experts, this is the first in-depth and exhaustive analysis of the genomics of the Aspergilli.

    Genomics of the Aspergilli

    An Overview of the Genus Aspergillus, S.E. Baker and J.W. Bennett
    A First Glance into the Genome Sequence of Aspergillus flavus, G.A. Payne, J. Yu, W.C. Nierman, M. Machida, D. Bhatnagar, T.E. Cleveland, and R.A. Dean
    A Comparative View of the Genome of Aspergillus fumigatus, N.D. Fedorova, W.C. Nierman, G. Turner, V. Joardar, R. Maiti, M.J. Anderson, D.W. Denning, and J.R. Wortman
    The Aspergillus nidulans Genome and a Comparative Analysis of Genome Evolution in Aspergillus, A. Rokas and J.E. Galagan
    Aspergillus nidulans Linkage Map and Genome Sequence: Closing Gaps and Adding Telomeres, J. Clutterbuck and M. Farman
    The Genome Sequence of Aspergillus oryzae, M. Machida

    Basic Biology of the Aspergilli

    Signal Transduction in Aspergilli, J.-H. Yu and C. d ’Enfert
    Gene Regulation, M.X. Caddick and C. Dobson
    Mitogen-Activated Protein Kinase Pathways in Aspergilli, G.S. May
    Gluconeogenic Carbon Metabolism, M.J. Hynes
    Amino Acid Supply of Aspergillus, O.W. Draht, S. Busch, K. Hofmann, S. Braus-Stromeyer, K. Helmstaedt, G.H. Goldman, and G.H. Braus
    Endocytosis, J.C. Sánchez-Ferrero and M.A. Peñalva
    RNA Silencing in the Aspergilli, T.M. Hammond and N.P. Keller
    Hyphal Morphogenesis in Aspergillus nidulans, S.D. Harris
    Cytoskeleton,Polarized Growth,and the Cell Cycle in Aspergillus nidulans, R. Fischer, N. Takeshita, and J. Doonan
    The Nuclear Pore Complex and Transport in Aspergillus nidulans, E.A. Espeso and S.A. Osmani
    Sexual Development in Aspergillus nidulans, D.-M. Han, K.-S. Chae, and K.-H Han
    Aspergillus Transporters, G. Diallinas
    Chromatin in the Genus Aspergillus, C. Scazzocchio and A. Ramón
    Transposable Elements and Repeat-Induced Point Mutation in Aspergillus nidulans, Aspergillus fumigatus, and Aspergillus oryzae, A.J. Clutterbuck, V.V. Kapitonov, and J. Jurka

    Medically Important Aspects of the Genus

    Clinical Aspects of the Genus Aspergillus, W.J. Steinbach
    Pathogenicity Determinants and Allergens, S. Krappmann
    Mammalian Models of Aspergillosis, A.K. Zaas and W.J. Steinbach
    The Emerging Role of Mini-Host Models in the Study of Aspergillosis, G. Chamilos and D.P. Kontoyiannis

    Biotechnological Aspects of the Genus

    Food Products Fermented by Aspergillus oryzae, K. Abe and K. Gomi
    Aspergillus as a Cell Factory for Protein Production: Controlling Protease Activity in Fungal Production, M. Braaksma and P.J. Punt
    Mycotoxin Production and Prevention of Aflatoxin Contamination in Food and Feed, J. Yu, G. Payne, B.C. Campbell, B. Guo, T.E. Cleveland, J.F. Robens, N.P. Keller, J.W. Bennett, and W.C. Nierman

    Methods: Techniques and Resources

    Microarrays in Aspergillus Species, A. Breakspear and M. Momany
    Chemostats and Microarrays, M. Gent and K. Lanthaler
    Advances in Gene Manipulations Using Aspergillus nidulans, S.A. Osmani, M. Hynes, and B.R. Oakley
    Fluorescent Labels for Intracellular Structures and Organelles, B.R. Oakley and X. Xiang
    Aspergillus at the Fungal Genetics Stock Center, K. McCluskey

    "The individual chapters are well-written, well-organized (with many very good figures and summary tables) and include recent data.  I recommend this book, and it should be mandatory for those new to this field...this book would also be an excellecnt starting point for getting an overview of the current state of the field."

    -Jan Lehmbeck, Society for General Microbiology, Feb. 2009