The Benefit/Risk Ratio: A Handbook for the Rational Use of Potentially Hazardous Drugs, 1st Edition (Hardback) book cover

The Benefit/Risk Ratio

A Handbook for the Rational Use of Potentially Hazardous Drugs, 1st Edition

By Hans C. Korting, M. Schafer-Korting

CRC Press

400 pages | 2 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9780849327919
pub: 1998-07-24
SAVE ~$34.00
eBook (VitalSource) : 9780429131028
pub: 1998-07-24
from $28.98

FREE Standard Shipping!


The use of drugs as remedies for various types of diseases has a long tradition; however, it has only been recently recognized that the value of any given compound must be evaluated in light of its benefit to risk ratio. When prescribing drugs, physicians must look at the big picture of the drug's benefits in relation to its side effects and possible toxicity. The aim of this handbook is to compile data from various authors, providing clinicians with data that will optimize their decision making in selecting effective, low-risk drug treatments. It also provides research workers, including physicians, pharmacists, and basic scientists, with a sound basis for increasing knowledge of the risk/benefit ratios of various drugs.

Includes detailed assessments of the following types of drugs:

  • Antihypertensive agents

  • Diuretics

  • Anti-diabetic drugs

  • Anticonvulsant drugs

  • Drugs for Parkinson's disease

  • Antihistamines and antiserotonins

  • Cytokines and immunomodulators

  • Non-opioid analgesics and anti-inflammatory agents

  • Antibacterial agents

  • Antiviral agents

  • Drugs used in reproductive endocrinology

  • Systemic drugs for skin diseases

  • Topical liposome drugs

  • Topical glucocorticoids
  • Reviews

    "This book appears to be one of the first to examine risk and benefits of new drugs in a more quantitative manner…this book provides a solid overview of drug types and their benefit/risk ratio…This resource would compliment the collection of most health science libraries…Of special interest to those involved with drug development and pharmacology and therapeutics."

    --Reviewer: Dale A. Stirling, Environmental Historian/Information Specialist, E-STREAMS, Vol. 3, No. 4

    Table of Contents

    The Role and Analysis of Benefit and Risk in the Development of New Drugs, C. Chuang-Stein

    Prediction of the Benefit/Risk Ratio from In Vitro Data, R. Shrivastava, C. Bonnabry, and G. John

    Evaluation of Therapeutic Benefits and Toxicological Risks Using Structure-Activity Relational Expert Systems, H.S. Rosenkranz, G. Klopman, and O.T. Macina

    Improving the Therapeutic Index Through Unusual Routes of Application: Intra-Arterial Treatment of Liver Metastases, D. Civalleri, G. Numico, F. DeCian, and M. Esposito

    Establishing the Benefit/Risk Ratio with Combination Drugs, A. Thürmann and J. Hasford

    Improving the Therapeutic Index of Antineoplastic Agents through Additional Drugs, G. Numico, D. Civalleri, and M. Esposito

    Antihypertensive Agents, B. Schwartzkopff and B.E. Strauer

    Diuretics, J. Zhi

    Anti-Diabetic Drugs, P. Compagnucci and F. Santeusanio

    Anticonvulsant Drugs and Drugs for Parkinson's Disease, M.J. Eadie

    Antihistamines and Antiserotonins, G. Passalcqua and G.W. Canonica

    Cytokines and Immunomodulators, D.J. Peace, W. Wong, and K.T. Ferrer

    Non-Opioid Analgesics and Anti-Inflammatory Agents, G. Traversa and N. Magrini

    Toxicity Profile of Liposomal Anthracyclines, A. A. Gabizon

    Antibacterial Agents, R. Garraffo

    Antiviral Agents, J.M. Kilby

    Antifungal Agents, A.K. Gupta, P. De Doneker, and M. Heenen

    Drugs Used in Reproductive Endocrinology, J.F. Mortola

    Nicotine Preparations in Smoking, N.L. Benowitz and J. Pinney

    Systemic Drugs for Skin Diseases, H. Bocquet, L. Le Cleach, and J.-C. Roujeau

    Topical Liposome Drugs, H.C. Korting

    Topical Glucocorticoids, M. Schäfer-Korting and A. Gysler


    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Pharmacology
    MEDICAL / Toxicology