The Biorganic Chemistry of Enzymatic Catalysis
An Homage to Myron L. Bender
This volume grew out of a symposium organized by the students of Professor Myron L. Bender. His research focused on the mechanisms of enzymatic catalysis and was instrumental in showing that enzymes do not possess magical powers to accelerate reactions a trillion times on an average, but follow simple rules of chemistry. A group of scientists who were trained by Bender have contributed some of their work to this book to pay homage to their mentor. The range of topics covered is such that researchers and industry with interest in biological chemistry will gain knowledge from the advances being made in related fields. The book shows organic chemists what advances have taken place in biological chemistry and biochemists will discover how principles of organic chemistry can be applied to reveal the powers of enzymatic catalysis.
Table of Contents
A Tribute to Myron L. Bender (Irving M. Klotz). Myron Lee Bender-An Overview of Scientific Contributions (Fredric M. Menger). Catalytic Activity of 2-Substituted Imidazoles for Hydrolysis of Acyl Ester Derivatives (Masayasu Akiyama). Stoichiometry and Stability of __Cyclodextrin Complexes with Aromatic Substrates in Aqueous Solution (Kenneth A. Conners). An Artificial Enzyme (Valerian T. D'Souza). Mechanisms of Catalysis and Inhibition of ß-Lactamase (Anthony L. Fink). Effect of Ascorbic Acid and Copper on Proteins (Avi Golan-Goldhirsh, David T. Osuga, Andi O. Chen, and John R. Whitaker). Oxalyl Thiolesters, Novel Intermediates in Biological Systems (Gordon Hamilton). Cyclodextrin-Induced Regioselective Cleavages of Ribonucleic Acids (Makoto Komiyama). Esterase-Like Activity and Drug Binding of Human Serum Albumin (Yukihisa Kurono and Ken Ikeda). Identification and Characterization of Reaction Intermediates in the Chemical and Enzymatic Isomerization of ß,_-Unsaturated Ketones to _, ß-Unsaturated Ketones (Ralph M. Pollack). Boronic Acids Catalyze the Hydrolysis of Mandelonitrile (Galla Rao and Manfred Philipp). Activators and Inhibitors of Carboxypeptidase A-Catalyzed Hydrolyses (John F. Sebastian and Jeffery L. Frye). Mediation of Enzyme Catalysis by Intra- and Intersite Changes in Conformational State (Frederick C. Wedler). Effect of Glycosylation on the Enzymatic Activity of Tissue-Type Plasminogen Activators (Arthur J. Wittwer, Susan C. Howard, and Joseph Feder). Viologen Mediators of Desulfovibrio desulfuricans Hydrogenase: Structure-Function Relationships (E. Ziomek, W.G. Martin, and R.E. Williams). Index.