1st Edition

The Blood-Brain Barrier and Drug Delivery to the CNS




ISBN 9780367398668
Published September 5, 2019 by CRC Press
264 Pages

USD $69.95

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Book Description

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research.
Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques.
A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS

  • assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans
  • presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters
  • examines the multidrug resistance protein P-glycoprotein as a natural transporter
  • analyzes current drug designs to known requirements for transport
  • looks at drug delivery systems for the brain
  • and much more!
    Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.
  • Table of Contents

    History and Physiology of the Blood-Brain Barrier in Relation to Delivery of Drugs to the Brain
    Michael W. Bradbury
    Physicochemical Factors that Influence Brain Uptake
    Michael H. Abraham and James A. Platts
    The Development of In Vitro Models for the Blood-Brain and Blood-CSF Barriers
    Christiane Engelbertz, Dorothea Korte, Thorsten Nitz, Helmut Franke, Matthias Haselbach, Joachim Wegener, and Hans-Joachim Galla
    In Vitro Models of the Blood-Brain Barrier and Their Use in Drug Development
    R. Cecchelli, B. Dehouck, L. Descamps, L. Fenart, V. Buée-Scherrer, C. Duhem, G. Torpier, and M. P. Dehouck
    The Application of Microdialysis Techniques to the Study of Drug Transport Across the Blood-Brain Barrier
    A. G. de Boer, Elizabeth C. M. de Lange, Inez C. J. van der Sandt, and Douwe D. Breimer
    The Role of Brain Extracellular Fluid Production and Efflux Mechanisms in Drug Transport to the Brain
    David J. Begley, Anthony Regina, Françoise Roux, Ehsan Ullah Khan, Christopher Rollinson, and Joan Abbott
    The Relevance of P-Glycoprotein in Drug Transport to the Brain: The Use of Knockout Mice as a Model System
    Ulrich Mayer
    Specific Mechanisms for Transporting Drugs Into Brain
    Akira Tsuji
    Drug Metabolism in the Brain: Benefits and Risks
    Alain Minn, Ramon D. S. El-Bachá, Claire Bayol-Denizot, Philippe Lagrange, Funmilayo G. Suleman, and Daniela Gradinaru
    Targeting Macromolecules to the Central Nervous System
    Ulrich Bickel
    Using Nanoparticles to Target Drugs to the Central Nervous System
    Jörg Kreuter and Renad N. Alyautdin
    Basic CNS Drug Transport and Binding Kinetics In Vivo
    Albert Gjedde, Antony D. Gee, and Donald Frederick Smith

    ...
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    Editor(s)

    Biography

    David J. Begley, Michael W. Bradbury, Jörg Kreuter