2nd Edition

The Chemical Components of Tobacco and Tobacco Smoke

By Alan Rodgman, Thomas A. Perfetti Copyright 2013
    2332 Pages 3091 B/W Illustrations
    by CRC Press

    Authored by two longtime researchers in tobacco science, The Chemical Components of Tobacco and Tobacco Smoke, Second Edition chronicles the progress made from late 2008 through 2011 by scientists in the field of tobacco science. The book examines the isolation and characterization of each component. It explores developments in pertinent analytical technology and results of experimental studies on biological activity, toxicity, and tumorigenicity, including the inhibition of adverse biological activity of one specific tobacco smoke component by another tobacco smoke component.

    Adding to the progress reported in the First Edition, the comprehensive Second Edition provides nearly 7,000 references on almost 9,600 components. The authors discuss the controversies over the extrapolation of the biological effect of a specific component administered individually by one route versus its biological effect when the component is in a highly complex mixture and is administered by a different route. They also cite studies in which cigarette design technologies were developed to control the per-cigarette mainstream smoke yield of Federal Trade Commission–defined tar and one or more specific tobacco smoke components of concern.

    New in the Second Edition:

    • Approximately 1,000 newly reported components have been inserted and several dozen duplicates have been deleted from various tables and from the Alphabetical Index
    • Improved and sharper chemical structures
    • Insertion of new pertinent references for the components in each of the major chapter tables devoted to a particular functional component
    • Updated Index organized by the CAS Registry Number listing of the components
    • Updated discussions in the Introduction and at the beginning of each chapter
    • A searchable companion CD-ROM containing the 350-page alphabetical Component Index

    Authors Alan Rodgman and Thomas A. Perfetti were jointly awarded the 2010 CORESTA (Cooperative Centre for Scientific Research Relative to Tobacco) Prize for their extensive work on documenting the vast literature on the chemical composition of tobacco and tobacco smoke in their original edition.


    Alkenes and Alkynes
    Alicyclic Hydrocarbons
    Monocyclic Aromatic Hydrocarbons
    Polycyclic Aromatic Hydrocarbons
    Alcohols and Phytosterols
    Aldehydes and Ketones
    Assertion of Aldehydes and Ketones as Ciliastatic Tobacco Smoke Components
    Ciliastasis Studies with Cigarette Smoke Condensate Fractions
    Ciliastasis Studies with Individual Cigarette Mainstream Smoke Components
    Nose Inhalation of Environmental Tobacco Smoke vs. Mouth Inhalation of Mainstream Smoke
    Carboxylic Acids
    Carboxylic Acids
    Amino Acids and Related Compounds
    Carbohydrates and Their Derivatives
    Phenols and Quinones
    Overall Summary of Oxygen-Containing Components of Tobacco and/or Smoke: Chapters 2 through 10
    Acyclic Amines
    Volatile NNAs
    Nonvolatile NNAs
    Tobacco-Specific NNAs
    N-Nitrosamino Acids
    Tobacco-Specific NNAs: An Exception among the Major MSS Toxicants
    Direct Transfer of TSNAs from Tobacco vs. Their Formation during the Smoking Process
    Infrequently Studied Tobacco and/or Smoke Secondary Amines and Their N-Nitroamines
    Flue Curing and TSNAs
    Nitroalkanes, Nitroarenes, and Nitrophenols
    Nitrogen Heterocyclic Components
    Monocyclic Four and Five-Membered N-Containing Ring Compounds
    Monocyclic Six-Membered N-Containing Ring Compounds
    Oxazoles and Oxazines
    N-Heterocyclic Amines
    Miscellaneous Components
    Sulfur-Containing Components
    Halogenated Components
    Fixed and Variable Gases
    Analytical Methods
    Metallic and Nonmetallic Elements, Isotopes, Ions, and Salts
    Elements, Isotopes, and Ions in Plants
    Methods for the Detection and Identification of Metals, Ions, and Isotopes in Tobacco and Tobacco Smoke
    The Transference of Elements, Isotopes, and Ions from Tobacco to Tobacco Smoke
    Pesticides and Growth Regulators
    Synthetic Pesticides and Plant Growth Regulator Residues on Tobacco
    Naturally Occurring Plant Growth Regulators and Pesticides in Tobacco
    Transfer Rates of Pesticides and Plant Growth Regulators to MSS
    Decomposition Products of Agrochemicals in MSS
    Methods for Analyses of Pesticides and Plant Growth Regulators
    Residues of Synthetic Pesticides and Plant Growth Regulators Identified in Tobacco and Tobacco Smoke
    Genes, Nucleotides, and Enzymes
    General Discussion of Genetics
    Tobacco Genetics
    Genes, Nucleotides, and Enzymes Identified in Tobacco
    Hoffmann Analytes
    Tobacco and/or Tobacco Smoke Components Used as Tobacco Ingredients
    Individual Tobacco Types
    Extracts from Tobacco
    Individual Tobacco Components
    Tobacco Additives
    Cigarette Construction Materials (Paper, Adhesives, etc.)
    Flavoring Ingredients
    Carcinogens, Tumorigens, and Mutagens vs. Anticarcinogens, Inhibitors, and Antimutagens
    Carcinogens, Tumorigens, and Mutagens
    Anticarcinogens, Inhibitors, and Antimutagens
    Free Radicals
    Analytical Methods for Determination of Free Radicals
    Free Radicals in Tobacco Smoke
    Historical Review of Free-Radical Research on Cigarette Smoke
    Proposed Mechanism for the Generation of Free Radicals in MSS

    Alphabetical Component Index
    Sequence of CAS Registry Numbers


    Alan Rodgman, Thomas A. Perfetti

    Praise for the First Edition

    … the real value of the book will turn out in its daily use and it has all chances to become the standard reference book (perhaps 'The Bible') of all tobacco scientists.
    —Dr. Gerhard Scherer, Editor of Beitrage zur Tabakforschung International, Bonn, Germany

    I highly recommend this book as an indispensable reference source for tobacco and smoke chemists as well as other scientists involved in the study of tobacco and its products. The compilation of proper chemical names, common names, Chemical Abstract Service numbers (CAS No.), and structures alone are worth the purchase price.
    —Charles R. Green, Ph.D., Retired Senior Principal Scientist, R. J. Reynolds Tobacco Company, Winston-Salem, North Carolina

    Many congratulations on this monumental piece of work.
    —Dr. Chuan Liu, Senior Scientist, Applied Research, Group Research & Development, British American Tobacco, Southampton, United Kingdom

    As a statistician I would like to forecast: There will not be any other comprehensive work in the next 30-50 years about this topic – Rodgman – Perfetti will be the definitive book.
    —Prof. Dr. Wolf-Dieter Heller, Karlsruhe, Germany

    as a reference text on a laboratory shelf it will prove essential and take its place alongside the other CRC publications.
    —M. Cooke, Chromatographia 2010, 71