The Chemical Components of Tobacco and Tobacco Smoke: 2nd Edition (Hardback) book cover

The Chemical Components of Tobacco and Tobacco Smoke

2nd Edition

By Alan Rodgman, Thomas A. Perfetti

CRC Press

2,332 pages | 3091 B/W Illus.

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Hardback: 9781466515482
pub: 2013-02-25
eBook (VitalSource) : 9780429096266
pub: 2016-04-19
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Authored by two longtime researchers in tobacco science, The Chemical Components of Tobacco and Tobacco Smoke, Second Editionchronicles the progress made from late 2008 through 2011 by scientists in the field of tobacco science.The book examines the isolation and characterization of each component. It explores developments in pertinent analytical technology and results of experimental studies on biological activity, toxicity, and tumorigenicity, including the inhibition of adverse biological activity of one specific tobacco smoke component by another tobacco smoke component.

Adding to the progress reported in the First Edition, the comprehensive Second Editionprovides nearly 7,000 references on almost 9,600 components.The authors discuss the controversies over the extrapolation of the biological effect of a specific component administered individually by one route versus its biological effect when the component is in a highly complex mixture and is administered by a different route. They also cite studies in which cigarette design technologies were developed to control the per-cigarette mainstream smoke yield of Federal Trade Commission–defined tar and one or more specific tobacco smoke components of concern.

New in the Second Edition:

  • Approximately 1,000 newly reported components have been inserted and several dozen duplicates have been deleted from various tables and from the Alphabetical Index
  • Improved and sharper chemical structures
  • Insertion of new pertinent references for the components in each of the major chapter tables devoted to a particular functional component
  • Updated Index organized by the CAS Registry Number listing of the components
  • Updated discussions in the Introduction and at the beginning of each chapter
  • A searchable companion CD-ROM containing the 350-page alphabetical Component Index

Authors Alan Rodgman and Thomas A. Perfetti were jointly awarded the 2010 CORESTA (Cooperative Centre for Scientific Research Relative to Tobacco) Prize for their extensive work on documenting the vast literature on the chemical composition of tobacco and tobacco smoke in their original edition.



Praise for the First Edition

… the real value of the book will turn out in its daily use and it has all chances to become the standard reference book (perhaps 'The Bible') of all tobacco scientists.

—Dr. Gerhard Scherer, Editor of Beitrage zur Tabakforschung International, Bonn, Germany

I highly recommend this book as an indispensable reference source for tobacco and smoke chemists as well as other scientists involved in the study of tobacco and its products. The compilation of proper chemical names, common names, Chemical Abstract Service numbers (CAS No.), and structures alone are worth the purchase price.

—Charles R. Green, Ph.D., Retired Senior Principal Scientist, R. J. Reynolds Tobacco Company, Winston-Salem, North Carolina

Many congratulations on this monumental piece of work.

—Dr. Chuan Liu, Senior Scientist, Applied Research, Group Research & Development, British American Tobacco, Southampton, United Kingdom

As a statistician I would like to forecast: There will not be any other comprehensive work in the next 30-50 years about this topic – Rodgman – Perfetti will be the definitive book.

—Prof. Dr. Wolf-Dieter Heller, Karlsruhe, Germany

as a reference text on a laboratory shelf it will prove essential and take its place alongside the other CRC publications.

—M. Cooke, Chromatographia 2010, 71

Table of Contents



Alkenes and Alkynes

Alicyclic Hydrocarbons

Monocyclic Aromatic Hydrocarbons

Polycyclic Aromatic Hydrocarbons


Alcohols and Phytosterols



Aldehydes and Ketones

Assertion of Aldehydes and Ketones as Ciliastatic Tobacco Smoke Components

Ciliastasis Studies with Cigarette Smoke Condensate Fractions

Ciliastasis Studies with Individual Cigarette Mainstream Smoke Components

Nose Inhalation of Environmental Tobacco Smoke vs. Mouth Inhalation of Mainstream Smoke

Carboxylic Acids

Carboxylic Acids

Amino Acids and Related Compounds




Carbohydrates and Their Derivatives

Phenols and Quinones




Overall Summary of Oxygen-Containing Components of Tobacco and/or Smoke: Chapters 2 through 10


Acyclic Amines




Volatile NNAs

Nonvolatile NNAs

Tobacco-Specific NNAs

N-Nitrosamino Acids

Tobacco-Specific NNAs: An Exception among the Major MSS Toxicants

Direct Transfer of TSNAs from Tobacco vs. Their Formation during the Smoking Process

Infrequently Studied Tobacco and/or Smoke Secondary Amines and Their N-Nitroamines

Flue Curing and TSNAs

Nitroalkanes, Nitroarenes, and Nitrophenols

Nitrogen Heterocyclic Components

Monocyclic Four and Five-Membered N-Containing Ring Compounds

Monocyclic Six-Membered N-Containing Ring Compounds


Oxazoles and Oxazines


N-Heterocyclic Amines

Miscellaneous Components

Sulfur-Containing Components

Halogenated Components

Fixed and Variable Gases

Analytical Methods

Metallic and Nonmetallic Elements, Isotopes, Ions, and Salts

Elements, Isotopes, and Ions in Plants

Methods for the Detection and Identification of Metals, Ions, and Isotopes in Tobacco and Tobacco Smoke

The Transference of Elements, Isotopes, and Ions from Tobacco to Tobacco Smoke


Pesticides and Growth Regulators

Synthetic Pesticides and Plant Growth Regulator Residues on Tobacco

Naturally Occurring Plant Growth Regulators and Pesticides in Tobacco

Transfer Rates of Pesticides and Plant Growth Regulators to MSS

Decomposition Products of Agrochemicals in MSS

Methods for Analyses of Pesticides and Plant Growth Regulators

Residues of Synthetic Pesticides and Plant Growth Regulators Identified in Tobacco and Tobacco Smoke

Genes, Nucleotides, and Enzymes

General Discussion of Genetics

Tobacco Genetics

Genes, Nucleotides, and Enzymes Identified in Tobacco


Hoffmann Analytes

Tobacco and/or Tobacco Smoke Components Used as Tobacco Ingredients



Individual Tobacco Types

Extracts from Tobacco

Individual Tobacco Components

Tobacco Additives

Cigarette Construction Materials (Paper, Adhesives, etc.)

Flavoring Ingredients

Carcinogens, Tumorigens, and Mutagens vs. Anticarcinogens, Inhibitors, and Antimutagens

Carcinogens, Tumorigens, and Mutagens

Anticarcinogens, Inhibitors, and Antimutagens


Free Radicals


Analytical Methods for Determination of Free Radicals

Free Radicals in Tobacco Smoke

Historical Review of Free-Radical Research on Cigarette Smoke

Proposed Mechanism for the Generation of Free Radicals in MSS



Alphabetical Component Index

Sequence of CAS Registry Numbers

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Toxicology
SCIENCE / Chemistry / Analytic
SCIENCE / Environmental Science