The Chemical Components of Tobacco and Tobacco Smoke  book cover
2nd Edition

The Chemical Components of Tobacco and Tobacco Smoke

ISBN 9781466515482
Published February 25, 2013 by CRC Press
2332 Pages 3091 B/W Illustrations

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Book Description

Authored by two longtime researchers in tobacco science, The Chemical Components of Tobacco and Tobacco Smoke, Second Edition chronicles the progress made from late 2008 through 2011 by scientists in the field of tobacco science. The book examines the isolation and characterization of each component. It explores developments in pertinent analytical technology and results of experimental studies on biological activity, toxicity, and tumorigenicity, including the inhibition of adverse biological activity of one specific tobacco smoke component by another tobacco smoke component.

Adding to the progress reported in the First Edition, the comprehensive Second Edition provides nearly 7,000 references on almost 9,600 components. The authors discuss the controversies over the extrapolation of the biological effect of a specific component administered individually by one route versus its biological effect when the component is in a highly complex mixture and is administered by a different route. They also cite studies in which cigarette design technologies were developed to control the per-cigarette mainstream smoke yield of Federal Trade Commission–defined tar and one or more specific tobacco smoke components of concern.

New in the Second Edition:

  • Approximately 1,000 newly reported components have been inserted and several dozen duplicates have been deleted from various tables and from the Alphabetical Index
  • Improved and sharper chemical structures
  • Insertion of new pertinent references for the components in each of the major chapter tables devoted to a particular functional component
  • Updated Index organized by the CAS Registry Number listing of the components
  • Updated discussions in the Introduction and at the beginning of each chapter
  • A searchable companion CD-ROM containing the 350-page alphabetical Component Index

Authors Alan Rodgman and Thomas A. Perfetti were jointly awarded the 2010 CORESTA (Cooperative Centre for Scientific Research Relative to Tobacco) Prize for their extensive work on documenting the vast literature on the chemical composition of tobacco and tobacco smoke in their original edition.


Table of Contents

Alkenes and Alkynes
Alicyclic Hydrocarbons
Monocyclic Aromatic Hydrocarbons
Polycyclic Aromatic Hydrocarbons
Alcohols and Phytosterols
Aldehydes and Ketones
Assertion of Aldehydes and Ketones as Ciliastatic Tobacco Smoke Components
Ciliastasis Studies with Cigarette Smoke Condensate Fractions
Ciliastasis Studies with Individual Cigarette Mainstream Smoke Components
Nose Inhalation of Environmental Tobacco Smoke vs. Mouth Inhalation of Mainstream Smoke
Carboxylic Acids
Carboxylic Acids
Amino Acids and Related Compounds
Carbohydrates and Their Derivatives
Phenols and Quinones
Overall Summary of Oxygen-Containing Components of Tobacco and/or Smoke: Chapters 2 through 10
Acyclic Amines
Volatile NNAs
Nonvolatile NNAs
Tobacco-Specific NNAs
N-Nitrosamino Acids
Tobacco-Specific NNAs: An Exception among the Major MSS Toxicants
Direct Transfer of TSNAs from Tobacco vs. Their Formation during the Smoking Process
Infrequently Studied Tobacco and/or Smoke Secondary Amines and Their N-Nitroamines
Flue Curing and TSNAs
Nitroalkanes, Nitroarenes, and Nitrophenols
Nitrogen Heterocyclic Components
Monocyclic Four and Five-Membered N-Containing Ring Compounds
Monocyclic Six-Membered N-Containing Ring Compounds
Oxazoles and Oxazines
N-Heterocyclic Amines
Miscellaneous Components
Sulfur-Containing Components
Halogenated Components
Fixed and Variable Gases
Analytical Methods
Metallic and Nonmetallic Elements, Isotopes, Ions, and Salts
Elements, Isotopes, and Ions in Plants
Methods for the Detection and Identification of Metals, Ions, and Isotopes in Tobacco and Tobacco Smoke
The Transference of Elements, Isotopes, and Ions from Tobacco to Tobacco Smoke
Pesticides and Growth Regulators
Synthetic Pesticides and Plant Growth Regulator Residues on Tobacco
Naturally Occurring Plant Growth Regulators and Pesticides in Tobacco
Transfer Rates of Pesticides and Plant Growth Regulators to MSS
Decomposition Products of Agrochemicals in MSS
Methods for Analyses of Pesticides and Plant Growth Regulators
Residues of Synthetic Pesticides and Plant Growth Regulators Identified in Tobacco and Tobacco Smoke
Genes, Nucleotides, and Enzymes
General Discussion of Genetics
Tobacco Genetics
Genes, Nucleotides, and Enzymes Identified in Tobacco
Hoffmann Analytes
Tobacco and/or Tobacco Smoke Components Used as Tobacco Ingredients
Individual Tobacco Types
Extracts from Tobacco
Individual Tobacco Components
Tobacco Additives
Cigarette Construction Materials (Paper, Adhesives, etc.)
Flavoring Ingredients
Carcinogens, Tumorigens, and Mutagens vs. Anticarcinogens, Inhibitors, and Antimutagens
Carcinogens, Tumorigens, and Mutagens
Anticarcinogens, Inhibitors, and Antimutagens
Free Radicals
Analytical Methods for Determination of Free Radicals
Free Radicals in Tobacco Smoke
Historical Review of Free-Radical Research on Cigarette Smoke
Proposed Mechanism for the Generation of Free Radicals in MSS

Alphabetical Component Index
Sequence of CAS Registry Numbers

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Alan Rodgman, Thomas A. Perfetti


Praise for the First Edition

… the real value of the book will turn out in its daily use and it has all chances to become the standard reference book (perhaps 'The Bible') of all tobacco scientists.
—Dr. Gerhard Scherer, Editor of Beitrage zur Tabakforschung International, Bonn, Germany

I highly recommend this book as an indispensable reference source for tobacco and smoke chemists as well as other scientists involved in the study of tobacco and its products. The compilation of proper chemical names, common names, Chemical Abstract Service numbers (CAS No.), and structures alone are worth the purchase price.
—Charles R. Green, Ph.D., Retired Senior Principal Scientist, R. J. Reynolds Tobacco Company, Winston-Salem, North Carolina

Many congratulations on this monumental piece of work.
—Dr. Chuan Liu, Senior Scientist, Applied Research, Group Research & Development, British American Tobacco, Southampton, United Kingdom

As a statistician I would like to forecast: There will not be any other comprehensive work in the next 30-50 years about this topic – Rodgman – Perfetti will be the definitive book.
—Prof. Dr. Wolf-Dieter Heller, Karlsruhe, Germany

as a reference text on a laboratory shelf it will prove essential and take its place alongside the other CRC publications.
—M. Cooke, Chromatographia 2010, 71