The Chemistry of Ynamides Development, Syntheses, and Applications in Organic Synthesis

1. The Discovery of Ynamines and Ynamides: A Historical Perspective

Gwilherm Evano

2. Synthesis of Ynamides

Mounsef Lahboubi and Gwilherm Evano

3. The Cationic Chemistry of Ynamides, Useful Precursors of Keteniminium Ions

Pierre Thilmany and Gwilherm Evano

4. The Anionic Chemistry and Carbometallation of Ynamides

Alaâ Saadane and Gwilherm Evano

5. Radical Reactions of Ynamides

Qiaolan Yang, Diksha Singh, Vincent Debrauwer, Vincent Bizet, and Nicolas Blanchard

6. Transition Metal-Catalyzed Reactions of Ynamides

Manash Protim Gogoi, Shubham Dutta, Shashank Shandilya, and Akhila Kumar Sahoo

7. Ynamides as Precursors of Carbenes and Carbenoids

Joshua D. Priest and Paul W. Davies

8. Reversal of Regioselectivity in the Chemistry of Ynamides

Long-Wu Ye

9. Pericyclic Reactions of Ynamides

Lénaic Rummler, Nicolas Brach, Pierre Delmée, Logan Charton, Vincent Bizet, and Nicolas Blanchard

10. Ynamides in Multicomponent Reactions

Linwei Zeng and Sunliang Cui

11. Ynamides as Racemization-Free Coupling Reagents for Amide and Ester Bond Formation

Chunyu Han, Tao liu, Xue Zhang, and Junfeng Zhao

12. Ynamides in the Synthesis of Natural/Biologically Relevant Products

Cédric Theunissen

Biography

Gwilherm Evano studied chemistry at the École Normale Supérieure in Paris, France, and received his PhD from the Université Pierre et Marie Curie in 2002 under the supervision of Profs. François Couty and Claude Agami. After postdoctoral studies with Prof. James S. Panek at Boston University, working on natural product synthesis, he joined the CNRS as an associate professor in 2004. He then moved to the Université libre de Bruxelles, Belgium, where he became the head of the Laboratory of Organic Chemistry in 2012. His research focuses on natural/bioactive product synthesis, copper catalysis, photoredox catalysis, organometallic chemistry, and the chemistry of ynamides and other heteroatom-substituted alkynes as well as reactive intermediates.

Junfeng Zhao obtained his bachelor’s and master’s degrees from Beijing Normal University and Central China Normal University in 2001 and 2005, respectively. After one year of PhD candidate study at Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, he moved to Singapore to continue his PhD study at Nanyang Technological University and received his PhD in 2010. After postdoctoral research at Nanyang Technological University, University of Bonn, and University of Muenster from 2010 to 2013, Dr Zhao joined the University of Hong Kong as a research assistant professor. He started his independent career at Jiangxi Normal University as a full professor in 2014 and stayed there until 2020. In 2021, his research group moved to Guangzhou Medical University. Dr Zhao’s research interest focuses on the synthesis and modification of peptides and proteins as well as their application in drug discovery.