The Human Complement System in Health and Disease: 1st Edition (Hardback) book cover

The Human Complement System in Health and Disease

1st Edition

Edited by John E. Volanakis

CRC Press

672 pages

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Hardback: 9780824798987
pub: 1998-02-25
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This authoritative, single-source reference provides comprehensive examinations of the complement system-offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases.

Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease

  • describes the molecular architecture of the complement system

  • details the structure of complement genes

  • discusses gene organization as well as the topology and chemistry of ligand-binding sites and catalytic centers of complement proteins

  • analyzes complement organization and activation, including phylogeny and the newly discovered lectin pathway

  • elucidates the regulation of complement gene expression and the structure and function of bioactive peptides

  • explicates opsonic and immunoregulatory properties of complement fragments, endothelial responses, and interactions with viruses and bacteria

  • and more!
  • Reviews


    …essential reading for those working in basic or applied complement research and should be read by all clinical immunologists in training.

    "-Annals of the Rheumatic Diseases

    Table of Contents

    Introduction and Historical Notes, Michael M. Frank

    Molecular Architecture

    Overview of the Complement System, John E. Volanakis

    Clq and Mannose-Binding Lectin, Kenneth B. M. Reid

    Complement Enzymes, John E. Volanakis and Gérard J. Arlaud

    The Chemistry and Biology of C3, C4, and C5, John D. Lambris, Arvind Sahu, and Rick A. Wetsel

    Proteins of the Membrane Attack Complex, Mnason E. Plumb and James M. Sodetz

    Regulatory Proteins of Complement, M. Kathryn Liszewski and John P. Atkinson

    Complement Receptors, Joseph M. Ahearn and Ariella M. Rosengard

    Phylogeny of the Complement System, Masaru Nonaka

    Regulation of Complement Protein Gene Expression, Harvey R. Colten and Gérard Garnier


    Characterization of Complement Anaphylatoxins and Their Biological Responses, Julia A. Ember, Mark A. Jagels, and Tony E. Hugli

    Complement-Mediated Phagocytosis, Melvin Berger

    Cellular Responses to the Membrane Attack Complex, Carolyn Mold

    Regulation by Complement of Acquired Immunity, Michael C. Carroll and Douglas T. Fearon

    Endothelial Cell Responses to Complement Activation, Soheyla Saadi and Jeffrey L. Platt

    The Complement System in Reproduction, Teresa J. Oglesby

    Bacteria and Complement, Franz Petry and Michael Loos

    Complement and Viruses, Neil R. Cooper

    Complement and Disease

    Complement Deficiencies and Infection, Peter Densen

    Processing and Clearance of Immune Complexes by Complement and the Role of Complement in Immune Complex Diseases, Kevin A. Davies and Mark J. Walport

    C1 Inhibitor Gene and Hereditary Angioedema, Alvin E. Davis III

    Paroxysmal Nocturnal Hemoglobinuria and Complement, Wendell F. Rosse Complement in Central Nervous System Disorders, Moon L. Shin, Horea Rus, and Florin Niculescu

    Development of Clinically Useful Agents to Control Complement-Mediated Tissue Damage, Eric Wagner and Michael M. Frank

    Autoimmune Hemolytic Anemia, Alan D. Schreiber

    Complement and Glomerular Diseases, Clark West

    Role of Complement in Diseased and Normal Human Skin, Kim B. Yancey and Thomas J. Lawley

    Complement and Neuromuscular Diseases, Milan Basta and Marinos C. Dalakas

    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Internal Medicine