1st Edition

The Human Complement System in Health and Disease

Edited By

John E. Volanakis

ISBN 9780824798987
Published February 25, 1998 by CRC Press
672 Pages

USD $240.00

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Book Description

This authoritative, single-source reference provides comprehensive examinations of the complement system-offering recent findings in basic science on the structure, biology, physiology, and pathophysiology of complement proteins and the latest therapeutic approaches towards the control of complement-mediated diseases.
Written by over 40 international experts from North America, Europe, and Asia, The Human Complement System in Health and Disease

  • describes the molecular architecture of the complement system
  • details the structure of complement genes
  • discusses gene organization as well as the topology and chemistry of ligand-binding sites and catalytic centers of complement proteins
  • analyzes complement organization and activation, including phylogeny and the newly discovered lectin pathway
  • elucidates the regulation of complement gene expression and the structure and function of bioactive peptides
  • explicates opsonic and immunoregulatory properties of complement fragments, endothelial responses, and interactions with viruses and bacteria
  • and more!
  • Table of Contents

    Introduction and Historical Notes, Michael M. Frank

    Molecular Architecture

    Overview of the Complement System, John E. Volanakis
    Clq and Mannose-Binding Lectin, Kenneth B. M. Reid
    Complement Enzymes, John E. Volanakis and Gérard J. Arlaud
    The Chemistry and Biology of C3, C4, and C5, John D. Lambris, Arvind Sahu, and Rick A. Wetsel
    Proteins of the Membrane Attack Complex, Mnason E. Plumb and James M. Sodetz
    Regulatory Proteins of Complement, M. Kathryn Liszewski and John P. Atkinson
    Complement Receptors, Joseph M. Ahearn and Ariella M. Rosengard
    Phylogeny of the Complement System, Masaru Nonaka
    Regulation of Complement Protein Gene Expression, Harvey R. Colten and Gérard Garnier


    Characterization of Complement Anaphylatoxins and Their Biological Responses, Julia A. Ember, Mark A. Jagels, and Tony E. Hugli
    Complement-Mediated Phagocytosis, Melvin Berger
    Cellular Responses to the Membrane Attack Complex, Carolyn Mold
    Regulation by Complement of Acquired Immunity, Michael C. Carroll and Douglas T. Fearon
    Endothelial Cell Responses to Complement Activation, Soheyla Saadi and Jeffrey L. Platt
    The Complement System in Reproduction, Teresa J. Oglesby
    Bacteria and Complement, Franz Petry and Michael Loos
    Complement and Viruses, Neil R. Cooper

    Complement and Disease

    Complement Deficiencies and Infection, Peter Densen
    Processing and Clearance of Immune Complexes by Complement and the Role of Complement in Immune Complex Diseases, Kevin A. Davies and Mark J. Walport
    C1 Inhibitor Gene and Hereditary Angioedema, Alvin E. Davis III
    Paroxysmal Nocturnal Hemoglobinuria and Complement, Wendell F. Rosse Complement in Central Nervous System Disorders, Moon L. Shin, Horea Rus, and Florin Niculescu
    Development of Clinically Useful Agents to Control Complement-Mediated Tissue Damage, Eric Wagner and Michael M. Frank
    Autoimmune Hemolytic Anemia, Alan D. Schreiber
    Complement and Glomerular Diseases, Clark West
    Role of Complement in Diseased and Normal Human Skin, Kim B. Yancey and Thomas J. Lawley
    Complement and Neuromuscular Diseases, Milan Basta and Marinos C. Dalakas

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    …essential reading for those working in basic or applied complement research and should be read by all clinical immunologists in training.
    "-Annals of the Rheumatic Diseases