This text assesses the role of dendritic cells, T and B lymphocytes, epithelial and mast cells, eosinophils, neutrophils, macrophages, and their products in the initiation and progression of airway inflammation, regulation, and repair. It unveils advances in immunology and cell biology to generate new therapeutic regimens for inflammatory and allergic diseases,and offers unparalleled research from nearly 60 international contributors.
The cells of the pulmonary immune response: overview of the pulmonary immune response, Laurent P. Nicod; antigen-presenting cells, Henk C. Hoogsteden, Hamida Hammad, and Bart N. Lambrecht; CD4 T lymphocytes in allergic asthma, Mark Larche and A.B. Kay; B-Cell differentiation and IgE synthesis, Hamida Hammad and Bart N. Lambrecht; immune functions of mast cells and basophils, Sarbjit S. Saini; immune functions of human eosinophils, Paul J. Coffer, Patricia M. R.E. Silva, Marco A. Martins, and Leo Koenderman; immune functions of airway epithelium, Sundeep S. Salvi and Stephen T. Holgate. Regulation processes in the pulmonary immune response: tolerance to inhaled antigen, Elizabeth R. Jarman, Gerard F. Hoyne and Jonathan R. Lamb; sensitization to inhaled allergen, Susan L. Prescott; polarization of T-helper cells, Martien L. Kapsenberg, Eddy A. Wierenga, Pawel Kalinski and Esther C. De Jong; CD28 and B7 superfamily members - costimulation and regulation of T-cell function, Anthony J. Coyle, Stephen Manning, and Jose-Carlos Gutierrez-Ramos; control of lymphocyte trafficking through the lung, Reinhard Pabst and Thomas Tschernig; neuroimmune interactions in the pathogenesis of allergic asthma, Armin Braun, Wolfgang A. Nockher, and Harald Renz. Integrated immunology of airway inflammation: immunopathology of atopic and nonatopic asthma, Marc Humbert, Sun Ying, and Douglas S. Robinson; immunology of eosinophilic airway inflammation - what the animal models teach us, Bart N. Lambrecht, Leonie S. Van Rijt, and Harmjan Kuipers; regulation of cellular traffic in the asthmatic lung, Clare M. Lloyd and Jose-Carlos Gutierrez-Ramos; cytokine regulation of bronchial hyperresponsiveness, Johan C. Kips and Romain A. Pauwels; immunological functions of inflammatory mediators, Domenico Spina, Clive Page, Anthony P. Sampson, and Zuzana Diamant; virally induced eosinophilic airway inflammation, Wieslawa Olszewska and Peter J.M. Openshaw; airway remodelling as the outcome of a chronic immu