The Ischemic Penumbra presents the current status of concepts and research on this topic and identifies the latest methods for clinicians to quickly and efficiently recognize viable cerebral tissue for enhanced stroke management. Focusing on state-of-the-science technologies and current trends, the book examines imaging strategies utilizing PET, SP

    THE ISCHAEMIC PENUMBRA: AN OVERVIEW. The Ischaemic Penumbra: The Beginning. The Ischaemic Penumbra: Overview, Definition, and Criteria. Perfusion Thresholds in Cerebral Ischaemia. Duration and Thresholds of the Ischemic Penumbra in Different Species. The Ischaemic Cascade: Events Within the Penumbra. Multimodal Mapping of the Ischaemic Penumbra in Animal Models. Molecular Biology of the Penumbra.Selective Neuronal Loss. Inflammation and Reperfusion Injury Within the Penumbra. IMAGING THE PENUMBRA: OTHER APPROACHES. Imaging the Penumbra with PET Flumazenil. Imaging the Penumbra: PET FMISO. Can the Penumbra be Imaged Using SPECT? Imaging the Penumbra with MR in Animals. Penumbra Imaged with MRI in Humans. Imaging the Penumbra with CT. MR Imaging the Ischemic Penumbra: New Techniques. Clinical / Imaging Mismatch. The Topography of the Ischaemic Penumbra. The Penumbra and Intracerebral Hemorrhage. THE ISCHAEMIC PENUMBRA: IMPLICATIONS FOR THERAPY. Extending the Time Window for Therapy. MR in the Selection for Stroke Therapies


    Geoffrey A. Donnan, Jean-Claude Baron, Stephen M. Davis, Frank R. Sharp