108 Pages
17 B/W Illustrations
by
CRC Press
97 Pages
by
CRC Press
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Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecular mechanisms that govern cellular functions. The... Read more
Preface 1. The Discovery of JNK and Its Biological Functions 2. Regulation of JNK by Small GTPases 3. Physiological Roles of the Different JNKs: Lessons from the JNK Knockouts 4. The Biological Function of JNKKs (MKK4/MKK7 Knockout Mice) 5. The JNK Signal Transduction Pathway in Drosophila 6. Regulation of Apoptosis by the JNK Signaling Pathway 7. Oxidative Stress, JNK Activation and Cell Death 8. JNK as a Therapeutic Target
Biography
Anning Lin Ph.D. is an Associate Professor at Ben M ay Institute for Cancer Research and the Program Leader of the Cell Signaling and Gene Regulation Program of Cancer Research Center, University of Chicago, U.S.A. His main research interests include the function of the intracellular signaling network in programmed cell death and tumorigenesis, using the c-Jun N-terminal protein kinase (JNK) and IkB kinase (IKK) signaling pathways as molecular probes.
