The Laboratory Canine  book cover
1st Edition

The Laboratory Canine

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ISBN 9780849328930
Published October 2, 2006 by CRC Press
184 Pages 61 B/W Illustrations

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Book Description

Laboratory animals, including dogs, play an important role in biomedical research and medical advances. Dogs have a long history of use in research and have contributed enormously to the health and welfare of both humans and animals. The humane care and management of these animals is a fundamental component of their use in medical research.

The Laboratory Canine clearly presents basic background information covering subjects that apply specifically to dogs used in research settings, such as basic biological features, husbandry, management, veterinary care, experimental methodology, and resources. The book offers guidance on performing a detailed physical examination, including necessary veterinary supplies, clinical signs of illness, clinical conditions, and reference tables of widely used veterinary drugs. It discusses the human-animal bond or the relationship between people and animals and its significance and importance to the quality of research, the health of the animals, and the emotional health of staff caring for or working with animals.  It also examines anesthetic and surgical procedures that include pre-, intra-, and post-anesthesia/operative monitoring.  The Laboratory Canine contains reference charts for monitoring patients through post-operative recovery and reference tables for anesthetics and analgesics.

Because dogs are a highly visible species in the eyes of the public and regulators, it is important that individuals working with laboratory canines have the proper training and experience. This valuable resource is ideal for those charged with the care and use of canines in a research setting.

Table of Contents

Origin of the Dog
Dog Breeds
Dog Behavior
Anatomic and Physiologic Features of Dogs
Normative Values of the Dog
Facility Design Considerations
Room Construction Features (Macroenvironment)
Outdoor Housing
Cage Materials and Design (Microenvironment)
Cage Size Standards
Environmental Conditions
Animal Care
Nutrition and Water
Environmental Enrichment
Exercise Requirements
Daily Schedule
Weekly Schedule
Semimonthly Schedule
Room Sanitation Schedule
Sanitation Quality Assurance Monitoring
Animal Receipt
Animal Identification
Record Keeping
Husbandry Records
Census Records
Medical Records
Regulatory Agencies and Compliance
U.S. Department of Agriculture
Public Health Service, National Institutes of Health, and
Office for Laboratory Animal Welfare
U.S. Food and Drug Administration and U.S. Environmental
Protection Agency Good Laboratory Practice Regulations
The Association for Assessment and Accreditation of
Laboratory Animal Care International
State and Local Agencies
Institutional Animal Care and Use Committee
Occupational Health and Safety
Intestinal Helminthes
Infections Resulting from Bite Wounds
Human-Animal Bond
Preventative Health Program
Quarantine, Stabilization, and Acclimation
Colony Separation
Clinical Management
Basic Veterinary Supplies
The Physical Examination
Clinical Signs of Illness in Dogs
Common Clinical Problems
Viral Diseases
Canine Parvovirus
Canine Distemper
Canine Coronavirus
Kennel Cough
Bacterial Diseases
Parasitic Diseases
Fungal Diseases
Miscellaneous Diseases and Conditions
Interdigital Cysts
Juvenile Polyarteritis Syndrome: Beagle Pain Syndrome
Cherry Eye
Dental Conditions
Implant Problems
Traumatic Injuries
Behavioral Disorders
Treatment of Diseases
General Treatment of Diarrhea
General Treatment of Dehydration
General Treatment of Anorexia
Drug Dosages in Dogs
Disease Prevention Through Sanitation
Anesthesia, Analgesia, and Sedation
Common Definitions
Principles of General Anesthesia
Stages of Anesthesia
Stage I: Voluntary Excitement
Stage II: Involuntary Excitement or Delirium
Stage III: Surgical Anesthesia
Stage IV: Medullary Paralysis and Respiratory Arrest
Assessment of the Depth of Anesthesia
Preanesthetic Management
Characteristics of Commonly Used Preanesthetics
Choosing an Anesthetic Regimen
Characteristics of Commonly Used Injectable Anesthetics
Principles of Gas Anesthesia
Characteristics of Commonly Used Gas Anesthetics
Principles of Local Anesthesia
Aseptic Surgery
Facilities, Features, and Equipment
Endotracheal Intubation
Preoperative Preparation
Operating Room Procedures
Postsurgical Management
Guidelines for the Assessment of Signs of Pain in Animals
Blood Donors
Signs of Morbidity (State of Disease or Illness) in Animals
Selected Criteria for Euthanasia of Moribund (State of Dying)
Canine Handling and Restraint
Mechanical Restraint Devices
Sample Collection Methods
Blood Collection
Urine Collection
Cerebrospinal Fluid Collection
Collection of Feces
Bone Marrow Collection
Test Article/Compound Administration Techniques
Formulation Guidelines
Volume Guidelines
Oral Dosing
Injection Sites
Implantable Osmotic Minipumps
Electronic Resources
Canine Sources
Transportation Services/Resources
Laboratory Services
Cages, Research, and Veterinary Supplies
Contact Information

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”The canine is one of the more highly regulated animal species because of its public image as a family member and the ever-present human-animal bond relationship. … Specific requirements concerning their housing, environmental enrichment, and proper medical management of pain and distress are outlined with references for additional in-depth information. … Attention is paid to human safety and zoootic diseases as well as the humane and ethical treatment of the animals themselves throughout the handbook. The Laboratory Canine is a valuable addition to the previously reviewed The Laboratory Animal Pocket Reference Series. It is an excellent reference for the individual wanting to strengthen their knowledge of basic canine care and guidelines in the laboratory setting. The handbook is conveniently sized and well written in an organized, easy to read manner, which will benefit the novice animal caretaker and laboratory assistant from small facilities to large institutions.”
—Sandra L. Jex, DVM, ALN Magazine, April 2007

“The intended audience of the book, The Laboratory Canine,is personnel involved with the care and use of dogs in research. The main target would be anima care staff and veterinary technicians. The book gives a general overview of the husbandry and care of research dogs, normal biological data for beagles, general disease conditions, basic anesthesia and common drug dosages, and sample collection methods. The book may be of interest to pathologists through the provision of these basic values and procedures … provide a very good technical reference for those in the field. The index is through, allowing quick access to information. …”
—Dr. Cecile Baccanale, DVM, Director of Animal Health, Marshall BioResources, New York, Veterinary Pathology, 2007

"The Laboratory Canine is a well and clearly written book and easy and pleasant to read."

– P. Rauser, in Acta Veternaria Brno, 2007, Vol. 76


"The book is clearly written and adequately referenced and touches on all aspects of care of laboratory dogs . . . an excellent quick reference source . . . "

– In AJVR, January 2008, Vol. 69, No. 1