The Laboratory Swine: 2nd Edition (Paperback) book cover

The Laboratory Swine

2nd Edition

By Peter J. A. Bollen, Axel K. Hansen, Aage K Olsen Alstrup

CRC Press

138 pages | 31 Color Illus.

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Paperback: 9781439815281
pub: 2010-02-22
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pub: 2010-02-22
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Since the popular first edition was published more than a decade ago, the number of swine used in toxicity studies has increased as an alternative to commonly used non-rodent species, such as dogs and primates. A volume in the Laboratory Animal Pocket Reference Series, The Laboratory Swine, Second Edition maintains the high standard set by the previous edition and is poised to continue its legacy as the premier laboratory reference on the care and use of swine in the laboratory.

Emphasizes Humane Care and Use of Laboratory Swine

Addressing the biology, husbandry, management, veterinary care and research applications of both large and miniature swine, this color reference is a complete source of information on the species. It is thoroughly updated and includes a major revision to the anesthetics section. It also places a heightened focus on animal welfare and addresses important considerations related to genetically modified swine. The book is divided into six parts:

  • Important Biological Features examines everything from different breeds and behavior, to anatomical and physiological features, as well as digestive, cardiovascular, and pulmonary systems
  • Husbandry addresses housing, nutrition, sanitation, transportation, and more
  • Management and Quality Assurance looks at the impact of infections on animal research using swine, zoonotic diseases, legal regulations, genetic monitoring, and more
  • Veterinary Care covers a variety of topics, such as clinical examination, diseases, pain recognition, and post-operative management
  • Experimental Techniques addresses restraint, sampling techniques, basic surgical procedures, and other issues
  • Resources provides extensive references for further study, including handbooks, journals, and websites

The Laboratory Swine, Second Edition is ideal for animal caretakers, technicians, investigators, and laboratory animal veterinarians as a single-source reference that contributes to the humane care and use of swine in research.


The second editions of The Laboratory Swine and The Laboratory Rabbit are enhanced with full color illustrations. Both books have an extensively updated section on anesthesia, analgesia and use of humane techniques in animal research. The Laboratory Swine also provides new information on the use of genetically modified swine. Both new additions are valuable additions to the laboratory animal library collection.

—Nanette Kleinman, in ACLAM Newsletter, September 2010

This second edition provides a multitude of information that is greatly aided by the use of many color photographs. It would be a valuable addition to facility libraries that are readily available to animal technicians and caretakers.

Journal of the American Association of Laboratory Animal Science, 2010

Table of Contents

Important biological features


The Landrace

The Yorkshire, or Large White

The Duroc

The Hampshire

The Pietrain

Other Breeds

Hybrid Breeds

Miniature Breeds

The Vietnamese Potbelly Pig

The Ossabaw Island Hog



Anatomical and physiological features

Integument and Skeleton

Digestive System

Abdominal Organs

Cardiovascular System

Pulmonary System

Lymphatic and Endocrine System

Normative values



Environmental conditions

Temperature and Humidity




Environmental enrichment

Group Housing

Individual Housing


Nutrient Requirements

Feeding Levels





Record keeping

Securing welfare

Management and quality assurance

Microbiological monitoring

Infections in Swine and Their Impact on Experiments

Pathological Changes, Clinical Disease, and Mortality


Physiological Modulation

Competition between Microorganisms within the Animal

Interference with Reproduction

Interference with Oncogenesis

Contamination of Biological Products

Impact of the Normal Flora

Zoonotic Diseases

Legal Regulations

Precautions to Prevent Infections


Barrier Protection

Health Monitoring

Common Findings in Health Monitoring

Genetic monitoring


AAALAC International

ISO 9000

Veterinary care

Clinical examination of swine

Microbiological sampling

Diseases of swine

Therapeutic treatment

Pathological examination

Anesthesia and analgesia


Clinical Examination Prior to Anesthesia

Preoperative Fasting


Ear Vein Catheter

Induction of Anesthesia

Endotracheal Intubation


Artificial Ventilation

Thermal Support

Maintenance of Anesthesia

Inhalation Anesthesia






Nitrous Oxide

Injectable Anesthesia


Ketamine and Other Dissociatives


Adrenoreceptor (α2) Agonists



Medetomidine-Butorphanol-Ketamine (MBK)

Supplementary Analgesia

Fluid Infusion

Depth of Anesthesia

Monitoring during Anesthesia

Neuromuscular Blocking Agents

Postoperative Management

Clinical Signs of Postoperative Pain

Postoperative Analgesics

Anesthetic Emergencies

Laryngospasm and Edema


Experimental techniques


Sampling techniques

Blood Sampling

Urine and Feces

Cerebrospinal Fluid

Bile and Pancreatic Excretions

Administration of compounds

Basic surgical procedures


The Carotid Artery and the Internal Jugular Vein

The Carotid Artery

The Internal Jugular Vein

The External Jugular Vein

The Cephalic Vein

The Femoral Artery and Vein


Portal Vein Cannulation

The Hepatic Vein

The Pancreatic Duct

Exteriorization of Catheters

Catheter Sizes and Material

Catheter Maintenance

Safety testing of chemicals and drugs

Dermal Toxicology

Acute and Chronic Systemic Toxicology





Special issues regarding gene-modified swine





Internet resources

Swine and diet, and equipment

Miniature Swine Resources

Diet Resources



About the Authors/Editor

Peter J.A. Bollen, Ph.D., is the head of Biomedical Laboratory, the central animal facility of the University of Southern Denmark, Odense, where he also received his Ph.D. degree. He studied experimental zoology and laboratory animal science in Utrecht, the Netherlands, and laboratory animal science in London.

Axel Kornerup Hansen, Dr. Vet. Sci. DVM, is a professor of Laboratory Animal Science and Welfare at the Royal Veterinary and Agricultural University in Copenhagen, Denmark, from which he also graduated. He is the head of the Department of Veterinary Disease Biology, one of the four veterinary departments at the Faculty of Life Sciences of the University of Copenhagen, Denmark.

Aage Kristian Olsen Alstrup, Ph.D. DVM, is a graduate of the Royal Veterinary and Agricultural University in Copenhagen, Denmark, from which he also received his Ph.D. degree. He is responsible for animal models at the PET Center of Aarhus University Hospital, Denmark.

About the Series

Laboratory Animal Pocket Reference

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Veterinary Medicine / General
MEDICAL / Toxicology
MEDICAL / Research