The Laboratory Swine  book cover
2nd Edition

The Laboratory Swine

ISBN 9781439815281
Published February 22, 2010 by CRC Press
138 Pages 31 Color Illustrations

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Book Description

Since the popular first edition was published more than a decade ago, the number of swine used in toxicity studies has increased as an alternative to commonly used non-rodent species, such as dogs and primates. A volume in the Laboratory Animal Pocket Reference Series, The Laboratory Swine, Second Edition maintains the high standard set by the previous edition and is poised to continue its legacy as the premier laboratory reference on the care and use of swine in the laboratory.

Emphasizes Humane Care and Use of Laboratory Swine

Addressing the biology, husbandry, management, veterinary care and research applications of both large and miniature swine, this color reference is a complete source of information on the species. It is thoroughly updated and includes a major revision to the anesthetics section. It also places a heightened focus on animal welfare and addresses important considerations related to genetically modified swine. The book is divided into six parts:

  • Important Biological Features examines everything from different breeds and behavior, to anatomical and physiological features, as well as digestive, cardiovascular, and pulmonary systems
  • Husbandry addresses housing, nutrition, sanitation, transportation, and more
  • Management and Quality Assurance looks at the impact of infections on animal research using swine, zoonotic diseases, legal regulations, genetic monitoring, and more
  • Veterinary Care covers a variety of topics, such as clinical examination, diseases, pain recognition, and post-operative management
  • Experimental Techniques addresses restraint, sampling techniques, basic surgical procedures, and other issues
  • Resources provides extensive references for further study, including handbooks, journals, and websites

The Laboratory Swine, Second Edition is ideal for animal caretakers, technicians, investigators, and laboratory animal veterinarians as a single-source reference that contributes to the humane care and use of swine in research.

Table of Contents

Important biological features
The Landrace
The Yorkshire, or Large White
The Duroc
The Hampshire
The Pietrain
Other Breeds
Hybrid Breeds
Miniature Breeds
The Vietnamese Potbelly Pig
The Ossabaw Island Hog
Anatomical and physiological features
Integument and Skeleton
Digestive System
Abdominal Organs
Cardiovascular System
Pulmonary System
Lymphatic and Endocrine System
Normative values

Environmental conditions
Temperature and Humidity
Environmental enrichment
Group Housing
Individual Housing
Nutrient Requirements
Feeding Levels
Record keeping
Securing welfare

Management and quality assurance
Microbiological monitoring
Infections in Swine and Their Impact on Experiments
Pathological Changes, Clinical Disease, and Mortality
Physiological Modulation
Competition between Microorganisms within the Animal
Interference with Reproduction
Interference with Oncogenesis
Contamination of Biological Products
Impact of the Normal Flora
Zoonotic Diseases
Legal Regulations
Precautions to Prevent Infections
Barrier Protection
Health Monitoring
Common Findings in Health Monitoring
Genetic monitoring
AAALAC International
ISO 9000

Veterinary care
Clinical examination of swine
Microbiological sampling
Diseases of swine
Therapeutic treatment
Pathological examination
Anesthesia and analgesia
Clinical Examination Prior to Anesthesia
Preoperative Fasting
Ear Vein Catheter
Induction of Anesthesia
Endotracheal Intubation
Artificial Ventilation
Thermal Support
Maintenance of Anesthesia
Inhalation Anesthesia
Nitrous Oxide
Injectable Anesthesia
Ketamine and Other Dissociatives
Adrenoreceptor (α2) Agonists
Medetomidine-Butorphanol-Ketamine (MBK)
Supplementary Analgesia
Fluid Infusion
Depth of Anesthesia
Monitoring during Anesthesia
Neuromuscular Blocking Agents
Postoperative Management
Clinical Signs of Postoperative Pain
Postoperative Analgesics
Anesthetic Emergencies
Laryngospasm and Edema

Experimental techniques
Sampling techniques
Blood Sampling
Urine and Feces
Cerebrospinal Fluid
Bile and Pancreatic Excretions
Administration of compounds
Basic surgical procedures
The Carotid Artery and the Internal Jugular Vein
The Carotid Artery
The Internal Jugular Vein
The External Jugular Vein
The Cephalic Vein
The Femoral Artery and Vein
Portal Vein Cannulation
The Hepatic Vein
The Pancreatic Duct
Exteriorization of Catheters
Catheter Sizes and Material
Catheter Maintenance
Safety testing of chemicals and drugs
Dermal Toxicology
Acute and Chronic Systemic Toxicology
Special issues regarding gene-modified swine

Internet resources
Swine and diet, and equipment
Miniature Swine Resources
Diet Resources

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Peter J.A. Bollen, Ph.D., is the head of Biomedical Laboratory, the central animal facility of the University of Southern Denmark, Odense, where he also received his Ph.D. degree. He studied experimental zoology and laboratory animal science in Utrecht, the Netherlands, and laboratory animal science in London.
Axel Kornerup Hansen, Dr. Vet. Sci. DVM, is a professor of Laboratory Animal Science and Welfare at the Royal Veterinary and Agricultural University in Copenhagen, Denmark, from which he also graduated. He is the head of the Department of Veterinary Disease Biology, one of the four veterinary departments at the Faculty of Life Sciences of the University of Copenhagen, Denmark.
Aage Kristian Olsen Alstrup, Ph.D. DVM, is a graduate of the Royal Veterinary and Agricultural University in Copenhagen, Denmark, from which he also received his Ph.D. degree. He is responsible for animal models at the PET Center of Aarhus University Hospital, Denmark.


The second editions of The Laboratory Swine and The Laboratory Rabbit are enhanced with full color illustrations. Both books have an extensively updated section on anesthesia, analgesia and use of humane techniques in animal research. The Laboratory Swine also provides new information on the use of genetically modified swine. Both new additions are valuable additions to the laboratory animal library collection.
—Nanette Kleinman, in ACLAM Newsletter, September 2010

This second edition provides a multitude of information that is greatly aided by the use of many color photographs. It would be a valuable addition to facility libraries that are readily available to animal technicians and caretakers.
Journal of the American Association of Laboratory Animal Science, 2010