138 Pages 31 Color Illustrations
    by CRC Press

    138 Pages
    by CRC Press

    Since the popular first edition was published more than a decade ago, the number of swine used in toxicity studies has increased as an alternative to commonly used non-rodent species, such as dogs and primates. A volume in the Laboratory Animal Pocket Reference Series, The Laboratory Swine, Second Edition maintains the high standard set by the previous edition and is poised to continue its legacy as the premier laboratory reference on the care and use of swine in the laboratory.

    Emphasizes Humane Care and Use of Laboratory Swine

    Addressing the biology, husbandry, management, veterinary care and research applications of both large and miniature swine, this color reference is a complete source of information on the species. It is thoroughly updated and includes a major revision to the anesthetics section. It also places a heightened focus on animal welfare and addresses important considerations related to genetically modified swine. The book is divided into six parts:

    • Important Biological Features examines everything from different breeds and behavior, to anatomical and physiological features, as well as digestive, cardiovascular, and pulmonary systems
    • Husbandry addresses housing, nutrition, sanitation, transportation, and more
    • Management and Quality Assurance looks at the impact of infections on animal research using swine, zoonotic diseases, legal regulations, genetic monitoring, and more
    • Veterinary Care covers a variety of topics, such as clinical examination, diseases, pain recognition, and post-operative management
    • Experimental Techniques addresses restraint, sampling techniques, basic surgical procedures, and other issues
    • Resources provides extensive references for further study, including handbooks, journals, and websites

    The Laboratory Swine, Second Edition is ideal for animal caretakers, technicians, investigators, and laboratory animal veterinarians as a single-source reference that contributes to the humane care and use of swine in research.

    Important biological features
    The Landrace
    The Yorkshire, or Large White
    The Duroc
    The Hampshire
    The Pietrain
    Other Breeds
    Hybrid Breeds
    Miniature Breeds
    The Vietnamese Potbelly Pig
    The Ossabaw Island Hog
    Anatomical and physiological features
    Integument and Skeleton
    Digestive System
    Abdominal Organs
    Cardiovascular System
    Pulmonary System
    Lymphatic and Endocrine System
    Normative values

    Environmental conditions
    Temperature and Humidity
    Environmental enrichment
    Group Housing
    Individual Housing
    Nutrient Requirements
    Feeding Levels
    Record keeping
    Securing welfare

    Management and quality assurance
    Microbiological monitoring
    Infections in Swine and Their Impact on Experiments
    Pathological Changes, Clinical Disease, and Mortality
    Physiological Modulation
    Competition between Microorganisms within the Animal
    Interference with Reproduction
    Interference with Oncogenesis
    Contamination of Biological Products
    Impact of the Normal Flora
    Zoonotic Diseases
    Legal Regulations
    Precautions to Prevent Infections
    Barrier Protection
    Health Monitoring
    Common Findings in Health Monitoring
    Genetic monitoring
    AAALAC International
    ISO 9000

    Veterinary care
    Clinical examination of swine
    Microbiological sampling
    Diseases of swine
    Therapeutic treatment
    Pathological examination
    Anesthesia and analgesia
    Clinical Examination Prior to Anesthesia
    Preoperative Fasting
    Ear Vein Catheter
    Induction of Anesthesia
    Endotracheal Intubation
    Artificial Ventilation
    Thermal Support
    Maintenance of Anesthesia
    Inhalation Anesthesia
    Nitrous Oxide
    Injectable Anesthesia
    Ketamine and Other Dissociatives
    Adrenoreceptor (α2) Agonists
    Medetomidine-Butorphanol-Ketamine (MBK)
    Supplementary Analgesia
    Fluid Infusion
    Depth of Anesthesia
    Monitoring during Anesthesia
    Neuromuscular Blocking Agents
    Postoperative Management
    Clinical Signs of Postoperative Pain
    Postoperative Analgesics
    Anesthetic Emergencies
    Laryngospasm and Edema

    Experimental techniques
    Sampling techniques
    Blood Sampling
    Urine and Feces
    Cerebrospinal Fluid
    Bile and Pancreatic Excretions
    Administration of compounds
    Basic surgical procedures
    The Carotid Artery and the Internal Jugular Vein
    The Carotid Artery
    The Internal Jugular Vein
    The External Jugular Vein
    The Cephalic Vein
    The Femoral Artery and Vein
    Portal Vein Cannulation
    The Hepatic Vein
    The Pancreatic Duct
    Exteriorization of Catheters
    Catheter Sizes and Material
    Catheter Maintenance
    Safety testing of chemicals and drugs
    Dermal Toxicology
    Acute and Chronic Systemic Toxicology
    Special issues regarding gene-modified swine

    Internet resources
    Swine and diet, and equipment
    Miniature Swine Resources
    Diet Resources


    Peter J.A. Bollen, Ph.D., is the head of Biomedical Laboratory, the central animal facility of the University of Southern Denmark, Odense, where he also received his Ph.D. degree. He studied experimental zoology and laboratory animal science in Utrecht, the Netherlands, and laboratory animal science in London.
    Axel Kornerup Hansen, Dr. Vet. Sci. DVM, is a professor of Laboratory Animal Science and Welfare at the Royal Veterinary and Agricultural University in Copenhagen, Denmark, from which he also graduated. He is the head of the Department of Veterinary Disease Biology, one of the four veterinary departments at the Faculty of Life Sciences of the University of Copenhagen, Denmark.
    Aage Kristian Olsen Alstrup, Ph.D. DVM, is a graduate of the Royal Veterinary and Agricultural University in Copenhagen, Denmark, from which he also received his Ph.D. degree. He is responsible for animal models at the PET Center of Aarhus University Hospital, Denmark.

    The second editions of The Laboratory Swine and The Laboratory Rabbit are enhanced with full color illustrations. Both books have an extensively updated section on anesthesia, analgesia and use of humane techniques in animal research. The Laboratory Swine also provides new information on the use of genetically modified swine. Both new additions are valuable additions to the laboratory animal library collection.
    —Nanette Kleinman, in ACLAM Newsletter, September 2010

    This second edition provides a multitude of information that is greatly aided by the use of many color photographs. It would be a valuable addition to facility libraries that are readily available to animal technicians and caretakers.
    Journal of the American Association of Laboratory Animal Science, 2010