The Lymphoid Neoplasms 3ed: 3rd Edition (Hardback) book cover

The Lymphoid Neoplasms 3ed

3rd Edition

By Ian Magrath

CRC Press

1,689 pages | 50 Color Illus. | 330 B/W Illus.

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Description

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and, finally, to the pragmatic aspects of disease management. The authors synthesise for the reader apsects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research.

Table of Contents

INTRODUCTION

Introduction to the lymphoid neoplasms

Historical perspective: the evolution of modern concepts of lymphoid neoplasia

EPIDEMIOLOGY

Descriptive epidemiology

Causes and prevention of lymphoma

Immunologic and genetic predisposition

Epidemiology of exogenous human retroviruses associated with hematologic malignancies

Herpesviruses and lymphoma

Other microorganisms associated with lymphoid neoplasms

IMMUNOBIOLOGY

Overview of the immune system

Ontogeny of T and natural killer cells

Ontogeny of B cells

Cellular immunobiology of lymph nodes and spleen

Cellular immunobiology of extranodal lymphoid tissue

Biology of plasma cells

Interleukins and lymphoid neoplasia

Lymphocyte homing and the dissemination of lymphoid malignancies

Mouse models of human B lymphoid neoplasms

CLASSIFICATION AND PATHOGENESIS

Classification of lymphoid neoplasms

Borderlands between pathological entities: composite lymphomas

Chromosomal and molecular alterations in lymphoid malignancies: basic principles and detection methods

Molecular basis of chromosomal translocations

Genesis and consequences of genetic lesions in lymphoma classification

Gene expression patterns in lymphoma classification

Immunodeficieny, inherited and acquired, and lymphomagenesis

Chronic inflammation, including autoimmunity, and lymphogenesis

PATHOLOGY AND PATHOGENESIS OF SPECIFIC LYMPHOMAS

Lymphoblastic lymphomas and leukemias

Chronic lymphoid leukemias and u heavy chain disease

Hairy cell leukemia

Mantle cell lymphoma

Marginal zone lymphomas

Follicular lymphoma

Burkitt lymphoma

Diffuse large B cell lymphomas

Hodgkin lymphoma

Plasma cell neoplasms

Natural killer (NK) cell neoplasms

Anaplastic large cell lymphoma

Mycosis fungoides and Sezary Syndrome: pathophysiology and pathology

Other peripheral T cell lymphomas: pathology and molecular pathogenesis

PRESENTING FEATURES, DIAGNOSIS AND STAGING

Presenting features of lymphoid neoplasms

The art of histological diagnosis

Immunophenotyping as a diagnostic and prognostic tool

The utility of molecular genetic studies in the diagnosis, prognostic assessment and monitoring of lymphoid malignancies

Radiologic, ultrasound and magnetic resonance imaging

Radionuclide imaging

Staging systems and staging investigations at presentation

Special aspects of diagnosis in developing countries

Imaging lymphomas in developing countries

GENERAL PRINCIPLES OF MANAGEMENT

Emergency management in lymphoid malignancies

Systemic therapy of lymphoma

Role of radiation therapy

Response assessment and follow-up of the patient with malignant lymphoma

Prognostic factors and risk adaptation

Second-line therapy for lymphoid neoplasms

High-dose therapy with stem cell rescue

Management of lymphoid neoplasia during pregnancy

Management of lymphoid malignancies in the infant

Management of lymphoid neoplasms in the elderly

Management of lymphomas at extranodal locations

Special aspects of management of lymphomas in developing countries

Late effects of cancer treatment and quality of life

MANAGEMENT OF SPECIFIC DISEASES

Lymphoblastic lymphoma and leukemia in children

Acute lymphoblastic leukemia and lymphoma in adults

Small B cell lymphomas and leukemias with hairy cell leukemia

Mantle cell lymphoma

Marginal zone lymphomas

Follicular lymphoma

Burkitt lymphoma/leukemia in children

Burkitt and Burkitt like lymphoma/leukemia in adults

Diffuse large B cell lymphoma in children

Diffuse large B cell lymphomas in adults

Hodgkin lymphoma in adults

Hodgkin lymphoma in children

Plasma cell neoplasms

The management of natural killer cell malignancies

Anaplastic large cell lymphoma in adults

Anaplastic large cell lymphoma in children

Mycosis fungoides and Sezary Syndrome

Adult T-cell leukemia/lymphoma

Other peripheral T cell lymphomas

HIV-associated lymphoid neoplasms

Lymphoid neoplasms in immunodeficiency, immunosuppression, and autoimmunity

Uncommon histologic subtypes of non-Hodgkin lymphoma in children

FUTURE DIRECTIONS IN DIAGNOSIS AND TREATMENT

Molecular profiling and lymphoma diagnosis

New therapies for lymphoid neoplasms

Monoclonal antibody therapy for lymphomas and leukemias

Cellular therapies for lymphoma

Vaccine therapies

Lymphoma microenvironment

Molecular pathway therapy for non-Hodgkin lymphomas

Therapeutic strategies employing viral-associated targets

About the Author

Ian T. Magrath DSc (Med), FRCP, FRCPath
President, International Network for Cancer Treatment and Research,
Adjunct Professor of Pediatrics, Uniformed Services University of the Health Sciences,
International Network for Cancer Treatment and Research,
Brussels, Belgium

Section editors:

Kishor Bhatia PhD, FRCPath
Director, AIDS Malignancy Program
OHAM, NCI, NIH
Bethesda, MD
USA

Paolo Boffetta MD, MPH
Head of Environment Section, IARC
Lifestyle and Cancer Group
International Agency for Research on Cancer
Lyon
France

Claire Dearden BSc, MD, FRCP, FRCPath
Consultant Haematologist
Department of Haemato-Oncology
Royal Marsden NHS Foundation Trust and Institute of Cancer Research
London
UK

Volker Diehl MD, PhD
Professor of Internal Medicine, Hematology and Oncology
Honorary Chairman of German Hodgkin Study Group (GHSG)
Former Head of Department I of Internal Medicine
University Hospital Cologne
Cologne
Germany

Randy D. Gascoyne MD, FRCPC
Clinical Professor of Pathology
Department of Pathology and Laboratory Medicine
British Columbia Cancer Agency and
The University of British Columbia
Research Director, Centre for Lymphoid Cancers
Senior Scientist, BC Cancer Research Centre
Vancouver, BC
Canada

Hans Konrad Müller-Hermelink Prof. Dr. Dr. h. c.
Professor and Chairman
Institute of Pathology
University of Würzburg
Würzburg
Germany

Michael Potter MD
Scientist, Emeritus
Laboratory of Cell Biology and Genetics
National Cancer Institute, NIH
Bethesda, MD
USA

Ama Z. S. Rohatiner MD, FRCP
Professor of Haemato-Oncology
Department of Medical Oncology,
St. Bartholomew's Hospital
London
UK

Subject Categories

BISAC Subject Codes/Headings:
MED038000
MEDICAL / Hematology
MED062000
MEDICAL / Oncology